Search results for "Organization"

Proxy Mobile IPv6-Based Seamless Handover

2013

A prospective next generation wireless network is expected to integrate harmoniously into an IP-based core network. It is widely anticipated that IP-layer handover is a feasible solution to global mobility. However, the performance of IP-layer handover based on basic Mobile IP (MIP) cannot support real time services very well due to long handover delay. The Internet Engineering Task Force (IETF) Network-based Localized Mobility Management (NETLMM) working group developed a network-based localized mobility management protocol called Proxy Mobile IPv6 (PMIPv6) to reduce the handoff latency of MIPv6. Moreover, PMIPv6 provides the IP with the mobility to support User Equipments (UEs) without it…

Impacto de la Sociedad del Conocimiento en la universidad y en la comunicación científica

2014

A la largo de las dos últimas décadas y como resultado de la introducción y uso intensivo de las tecnologías de la información y del conocimiento en general y de internet en particular, la universidad esta viviendo un proceso de transformación complejo que afecta a sus estructuras académicas y organizativas así como también a su concepción de metodología docente. Las TIC han evidenciado la necesidad de establecer estrategias de coherencia institucional en su uso y aplicación, así como la posibilidad de ampliar los ámbitos de acción institucional y el acceso masivo a la formación superior. Y todo ello pone de manifiesto el cambio existente de un modelo de formación basado en la transmisión d…

Power and language in a multicultural workplace

2015

Today’s work markets are increasingly shaped by the multilingual reality. The present research offers an intercultural communication perspective on language diversity and power relations at modern work environment. Study investigates how young professionals and their foreign colleagues perceive diversity affecting in their communicative behaviours in culturally heterogeneous workplace. Analysis of data from participants has been conducted through an analysis of open ended self‐report questionnaire in a multinational company where English is used daily as a corporate language. In particular, results of present study indicate that more diverse language skills are attributed to perception of p…

The Participation of NGOs in the Dynamics of International Law-Making

2013

Audit and Earnings Management in Spanish SMEs

2016

Abstract Evidence about the relation between earnings management and voluntary audits is scarce, and there is no research about the effectiveness of mandatory audits to improve earnings quality. Using a sample of Spanish SMEs, where some companies are mandatorily audited and some are exempt from audit, we examine if audits, either mandatory or voluntary, help to improve accounting quality by constraining earnings management. We also examine differences between voluntary and mandatory audits, as well as the role of Big 4 and Middle-Tier auditors. After controlling for other characteristics that affect earnings management, we find that audited companies have lower absolute discretionary accru…

Shareholder Wealth Creation in Response to Announcements of Acquisitions of Unlisted Firms: Evidence from Spain

2011

We investigate shareholder value creation of Spanish listed firms in response to announcements of acquisitions of unlisted companies and compare this experience to the purchase of listed firms over the period 1991–2006. Similar to foreign markets, acquirers of listed targets earn insignificant average abnormal returns, whereas acquirers of unlisted targets gain significant positive average abnormal returns. When we relate these results to company and transaction characteristics our findings diverge from those reported in the literature for other foreign markets, as our evidence suggests that the listing status effect is mainly associated with the fact that unlisted firms tend to be smaller …

The Separating Role of Collateral Requirements in Credit Markets with Asymmetric Information

2001

In this paper we test Bester's (1985, 1987) prediction about the separating role of contracts that involve both interest rates and collateral requirements in credit markets. To test this prediction we use data from natural credit markets and controlled experiments. Using a sample of credits to small and medium size firms in Valencia, Spain, we relate two different types of contracts with the ex post risk type of the borrower and other relevant variables. We then design two incentive compatible contracts and analyze decisions under two different experimental treatments, one with moral hazard. Our empirical results confirm that borrowers of ex post lower risk choose contracts with higher coll…

Clinical and Functional Studies Reveal That TP73 Isoforms Levels Are Associated with Prognosis and RA-Resistance in Acute Promyelocytic Leukemia

2019

Background: TP73 isoforms gained particular relevance in acute promyelocytic leukemia (APL) since Bernasola et al (JEM. 2004) demonstrated that TAp73 was directly regulated by the PML protein in the nuclear body. The isoforms differ in their transcriptional activity, with those lacking domains in the N-terminal part of the protein exerting a dominant negative effect on TP73 function. In a retrospective analysis of patients with APL treated in ICAPL study, Lucena-Araujo et al (Blood 2015) demonstrated the association between higher ΔNp73/TAp73 ratio values and poor clinical outcome. However,there is a diversity of TP73 isoforms and specially those lacking N-terminal domains (e.g.ΔEx2p73, ΔEx…

Arsenic Trioxide Abrogate MN1 Mediated RA-Resistance in Acute Promyelocytic Leukemia

2019

Introduction: Described as a well know marker of worse prognosis in acute myeloid leukemia (AML), MN1 overexpression has been associated with inv(16) or EVI1 overexpression (Heuser et al., Blood 2007). The promoter region of the MN1 gene has Retinoic Acid Response Elements (RAREs), and higher levels of MN1 expression have been associated with decreased response to retinoic acid (RA) in vitro. Nevertheless, in the context of acute promyelocytic leukemia, little is known about MN1 gene expression and functionality in vivo. Aims: Here, we investigated the effects of in vitro treatment with RA plus arsenic trioxide (ATO) in APL cell lines and primary blasts overexpressing MN1. Additionally, we …

Utility-based resource allocations in multi-hop wireless networks

2011

It is well known that CSMA (Carrier Sense Multiple Access) protocols exhibit very poor performance in case of multi-hop transmissions, because of inter-link interference due to imperfect carrier sensing. Since ad-hoc networks based on multihop packet deliveries are becoming more and more common in different application and networking scenarios, different medium access control extensions are currently considered for improving the channel utilization efficiency. In this paper, we propose a simple approach based on preallocating temporal slots in which different sets of nodes are allowed to contend for the channel access, which can significantly improve CSMA performance with limited signaling …