Search results for "Organization"
showing 10 items of 4550 documents
Human resource development roles and competencies in five European countries
1998
This article compares HRD practitioners’ self-assessments based on their work roles, outputs and competencies from England, the Netherlands, Italy, Germany and Finland. The comparison is based on results produced by European surveys conducted between 1992–96, which adopted their model from an earlier study of HRD practitioners in the USA. In terms of work roles, the findings showed the culture-bound nature of HRD work and also, through the appearance of new work roles, its close relation to changes in working life. English and the Finnish HRD practitioners in particular, seemed to perceive themselves as agents of change while for the Germans, the role of trainer still seemed valid. In terms…
Managing the liberalization of Italy's retail electricity market: A policy proposal☆
2020
Abstract Italy will phase out electricity retail price regulation by July 1st, 2020. Until then, residential customers and small businesses who do not choose their supplier are served under a regulated tariff named “maggior tutela” (greater protection), supplied by the local distributor at a price set by the regulator. We review the literature on electricity retail competition – with particular regard to its expected effects on prices, innovation, and customer engagement – and the conditions under which competition is expected to deliver benefits. We perform a Structure-Conduct-Performance analysis of Italy's retail electricity market for residential customers, finding two issues potentiall…
Una strategia nazionale a difesa del Cyberspazio
2023
L’articolo intende proporre un’analisi circa lo stato dell’arte della sicurezza ci- bernetica in Italia, prestando particolare attenzione alle principali novità conte- nute all’interno della Strategia Nazionale di Cybersicurezza 2022-2026. Nello specifico, dopo aver offerto un inquadramento giuridico del fenomeno degli at- tacchi informatici, il contributo intende approfondire con una visione critica le future sfide che vedranno l’Italia e l’Europa protagoniste nella difesa del pro- prio “dominio cibernetico”. The article intends to propose an analysis about the state of the art of cyber security in Italy, paying particular attention to the main innovations contained in the National Cyberse…
Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons
2010
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All-Atom simulations disclose how cytochrome reductase reshapes the substrate access/egress routes of its partner cyp450s
2020
Cytochromes P450 enzymes (CYP450s) promote the oxidative metabolism of a variety of substrates via the electrons supplied by the cytochrome P450 reductase (CPR) and upon formation of a CPR/CYP450 adduct. In spite of the pivotal regulatory importance of this process, the impact of CPR binding on the functional properties of its partner CYP450 remains elusive. By performing multiple microsecond-long all-Atom molecular dynamics simulations of a 520â »000-Atom model of a CPR/CYP450 adduct embedded in a membrane mimic, we disclose the molecular terms for their interactions, considering the aromatase (HA) enzyme as a proxy of the CYP450 family. Our study strikingly unveils that CPR binding alters…
Polyphosphoinositide Metabolism and Golgi Complex Morphology in Hippocampal Neurons in Primary Culture is Altered by Chronic Ethanol Exposure
2012
Aims : Ethanol affects not only the cytoskeletal organization and activity, but also intracellular trafficking in neurons in the primary culture. Polyphosphoinositide (PPIn) are essential regulators of many important cell functions, including those mentioned, cytoskeleton integrity and intracellular vesicle trafficking. Since information about the effect of chronic ethanol exposure on PPIn metabolism in neurons is scarce, this study analysed the effect of this treatment on three of these phospholipids. Methods : Phosphatidylinositol (PtdIns) levels as well as the activity and/or levels of enzymes involved in their metabolism were analysed in neurons chronically exposed to ethanol. The level…
Indirect Discrimination and School Segregation of Roma Children in the Czech Republic
2018
In DH v. Czech Republic (2007), the Czech government argued that Roma parents consented to the assignment of their children to ‘special’ schools. According to the government, parental consent undermined the claim that the disproportionate assignment of Roma children to inferior schools amounted to discrimination. The court rejected the argument, finding as a matter of law that parents could not choose to subject their children to discriminatory education, and as a matter of fact that the parents’ consent was not informed. Since the judgment, the Czech government continues to disproportionately assign Roma children to inferior schools, but it has revised the procedure they use to obtain pare…
Bosnia and Herzegovina: assessing health systems capacity to manage large influx of refugees and migrants. Joint report on a mission of the Health Au…
2020
The large numbers of refugees and migrants arriving in and transiting through Bosnia and Herzegovina pose new challenges to the health system, which must adapt and respond to the needs of both migrants and residents. This requires an efficient policy dialogue between the main stakeholders to share experiences and identify best practices. The WHO Regional Office for Europe, through the Migration and Health programme, supports Member States for strengthening the health sector's capacity to provide evidence-informed responses to the public health challenges for refugee and migrant health. In this regard, a joint assessment mission was carried out in Bosnia and Herzegovina in 2019, using the WH…
Heterochromatin Networks: Topology, Dynamics, and Function (a Working Hypothesis)
2021
Open systems can only exist by self-organization as pulsing structures exchanging matter and energy with the outer world. This review is an attempt to reveal the organizational principles of the heterochromatin supra-intra-chromosomal network in terms of nonlinear thermodynamics. The accessibility of the linear information of the genetic code is regulated by constitutive heterochromatin (CHR) creating the positional information in a system of coordinates. These features include scale-free splitting-fusing of CHR with the boundary constraints of the nucleolus and nuclear envelope. The analysis of both the literature and our own data suggests a radial-concentric network as the main structural…
Thoughts on What Chemists Can Contribute to Fighting SARS-CoV-2 - A Short Note on Hand Sanitizers, Drug Candidates and Outreach.
2020
Abstract The SARS‐CoV‐2 outbreak causing the respiratory disease COVID‐19 has left many chemists in academia without an obvious option to contribute to fighting the pandemic. Some of our recent experiences indicate that there are ways to overcome this dilemma. A three‐pronged approach is proposed.