Search results for "Organizations"
showing 10 items of 864 documents
Strategies for Including Patients Recruited During Interim Analysis of Clinical Trials
2007
In clinical trials a periodical check of safety and efficacy data is often needed. For organizational reasons it is rarely desirable to stop a trial during such an interim analysis. Therefore, new study patients are included in the trial while the interim analysis is ongoing. Disregarding the additional information provided by these interim patients would be unsatisfactory, especially for an office of regulatory affairs. Consequently, the rules for group sequential or adaptive decisions must be adjusted to the recruitment of interim patients. In this paper, two strategies for modifying study designs to consider the analysis of interim patients are proposed.
Low-Flow Anaesthesia
2000
Healthcare reform has placed increasing pressure on anaesthetists to consider the costs of current anaesthesia strategies. Although the cost of anaesthesia constitutes only a small proportion of total healthcare costs, anaesthetic drug expenditures have been a focus of cost-containment efforts. Low-flow anaesthesia is a simple method of reducing the fresh gas flow rate for anaesthetic gases during inhalational anaesthesia. A knowledge of the pharmacokinetic behaviour of inhaled anaesthetics and the use of modern equipment and monitoring technology meet the requirements for safe application of this anaesthetic technique. Millions of patients receive general anaesthesia each year, and thus th…
Backbone of credit relationships in the Japanese credit market
2016
We detect the backbone of the weighted bipartite network of the Japanese credit market relationships. The backbone is detected by adapting a general method used in the investigation of weighted networks. With this approach we detect a backbone that is statistically validated against a null hypothesis of uniform diversification of loans for banks and firms. Our investigation is done year by year and it covers more than thirty years during the period from 1980 to 2011. We relate some of our findings with economic events that have characterized the Japanese credit market during the last years. The study of the time evolution of the backbone allows us to detect changes occurred in network size,…
Взаимодействие пионеров и октябрят в коллективе пионерской дружины
1987
Advisor: Шпона, Аусма
Subcellular distribution of choline acetyltransferase by immunogold electron microscopy in non-neuronal cells: Placenta, airways and murine embryonic…
2012
Abstract Aims Acetylcholine is synthesized in more or less all mammalian cells. However, little is known about the subcellular location of acetylcholine synthesis. Therefore, in the present experiments the subcellular location of the synthesizing enzyme choline acetyltransferase (ChAT) was investigated by anti-ChAT immunogold electron microscopy in human placenta and airways as well as in a murine embryonic stem cell line (CGR8 cell line). Main methods Human tissue was obtained as so-called surplus tissue (after delivery/surgical removal because of lung tumor); the CGR8 stem cell line was cultured under standard conditions. For human tissue a monoclonal mouse anti-ChAT antibody (ab) was use…
Tendencias actuales en la edición de revistas electrónicas: nueva etapa en Relieve
2014
Se revisa la evolución de la Revista Electrónica de Investigación y Evaluación Educativa (RELIEVE) desde su nacimiento. Se analizan igualmente las características y tendencias de las revistas electrónicas. Se sugieren algunas modificaciones para RELIEVE.
Family Carers’ Expectations and Strategies in Shaping Live-in Migrant Carer Arrangements: A Comparison Between Germany and the Netherlands
2021
Item does not contain fulltext This chapter analyzes different old-age care regimes with regard to the expectations family carers have vis-á-vis live-in migrant carer arrangements and the strategies they develop to shape them. It compares data from interviews with family carers in Germany and the Netherlands. While Germany’s old-age care regime places a high responsibility and financial burden on the family, the Netherlands provides a broad range of publicly funded health and social care services. The analysis reveals both differences and similarities between family carers in both countries. It shows that family carers in Germany rather favor family-like arrangements, whereas family carers …
A Characterization of Quintic Helices
2005
A polynomial curve of degree 5, @a, is a helix if and only if both @[email protected]^'@? and @[email protected]^'@[email protected]^''@? are polynomial functions.
Risk factors of Oral cancer- A hospital based case control study
2018
Background Oral cancer is a highly prevalent malignancy in Pakistan. Among various risk factors associated with this neoplasm, habits such as smoked and smokeless tobacco usage, betel quid, and betel nut consumption are the major culprits in our society. In the present study, we aimed to ascertain prevalent risk factors for OC in our population and to compare our findings with healthy controls to establish their significance. Material and methods A hospital-based case control study was conducted at Dow University of Health Sciences, Pakistan from January 2015 - September 2016. Information pertaining to unhealthy oral habits was obtained from 62 oral cancer patients (cases) and 62 healthy co…
Forecasting the Size Premium Over Different Horizons
2011
In this paper, we provide evidence that the small stock premium is predictable both in-sample and out-of-sample through the use of a set of lagged macroeconomic variables. We find that it is possible to forecast the size premium over time horizons that range from one month to one year. We demonstrate that the predictability of the size premium allows a portfolio manager to generate an economically and statistically significant active alpha.