Search results for "Orthomyxoviridae"

showing 6 items of 16 documents

A review of virus infections of cataceans and the potential impact of morbilliviruses, poxviruses and papillomaviruses on host population dynamics.

1999

Viruses belonging to 9 families have been detected in cetaceans. We critically review the clinical features, pathology and epidemiology of the diseases they cause. Cetacean morbillivirus (family Paramyxoviridae) induces a serious disease with a high mortality rate and persists in several populations. It may have long-term effects on the dynamics of cetacean populations either as enzootic infection or recurrent epizootics. The latter presumably have the more profound impact due to removal of sexually mature individuals. Members of the family Poxviridae infect several species of odontocetes, resulting in ring and tattoo skin lesions. Although poxviruses apparently do not induce a high mortali…

MaleParamyxoviridaePopulationViral diseasesPoxviridae InfectionsAquatic Sciencemedicine.disease_causeHepadnaviridaeHerpesviridae:CIENCIAS DE LA VIDA [UNESCO]AdenoviridaeCetacea [whales dolphins and porpoises]Papovaviridaebiology.animalUNESCO::CIENCIAS DE LA VIDAmedicineAnimalsUNESCO::CIENCIAS DE LA VIDA::Biología animal (Zoología)educationPapovaviridaePapillomaviridaeEcology Evolution Behavior and SystematicsHerpesviridaeeducation.field_of_studyCetaceans:CIENCIAS DE LA VIDA::Biología animal (Zoología) [UNESCO]biologyPoxviridaePapillomavirus InfectionsParamyxoviridae ; Poxviridae ; Papovaviridae ; Herpesviridae ; Orthomyxoviridae ; Rhabdoviridae ; Caliciviridae ; Hepadnaviridae ; Adenoviridae ; Cetaceans ; Viral diseasesPhocoena spinipinnisbiology.organism_classificationOrthomyxoviridaeVirologyCaliciviridaeCetacean morbillivirusTumor Virus InfectionsMorbillivirusParamyxoviridaeCetaceaRhabdoviridaeCaliciviridaePorpoiseMorbillivirus InfectionsDiseases of aquatic organisms
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Sociodemographic Factors and Clinical Conditions Associated to Hospitalization in Influenza A (H1N1) 2009 Virus Infected Patients in Spain, 2009–2010

2012

The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalizatio…

MaleViral DiseasesPediatricsNon-Clinical MedicinePulmonologyEpidemiology:Named Groups::Persons::Age Groups::Adult::Aged::Aged 80 and over [Medical Subject Headings]Grip A (H1N1):Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]DiseaseSocial and Behavioral Sciencesmedicine.disease_cause:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]Hospital patients:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Influenza A Virus H1N1 SubtypeGripe humanaSociologyRisk FactorsPandemicInfluenza A virusChildAged 80 and over:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]:Organisms::Viruses::Vertebrate Viruses::RNA Viruses::Orthomyxoviridae::Influenzavirus A::Influenza A virus::Influenza A Virus H1N1 Subtype [Medical Subject Headings]COPDeducation.field_of_studyMultidisciplinary:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]QRMiddle AgedHospitalizationInfectious Diseases:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization [Medical Subject Headings]Child Preschool:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]MedicineFemalePublic Health:Named Groups::Persons::Age Groups::Infant [Medical Subject Headings]Assistència hospitalàriaResearch ArticleAdultmedicine.medical_specialtyAdolescent:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]SciencePopulationHospitals -- Pacients:Check Tags::Male [Medical Subject Headings]:Named Groups::Persons::Age Groups::Infant::Infant Newborn [Medical Subject Headings]InfluenzavirusVirusYoung AdultInfluenza HumanSubtipo H1N1 del Virus de la Influenza A:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]medicineInfluenza virusesHumansEpidemiologia -- Investigació -- EspanyaEspanyaEpidemiologiaeducationPandemicsBiology:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]AgedHospital carePopulation Biologybusiness.industryPublic healthInfant NewbornCase-control studyInfant:Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings]medicine.disease:Check Tags::Female [Medical Subject Headings]SpainCase-Control StudiesH1N1 influenza:Diseases::Virus Diseases::RNA Virus Infections::Orthomyxoviridae Infections::Influenza Human [Medical Subject Headings]businessPLoS ONE
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Protective effect of adenylate deaminase (from Penicillium lanoso-viride) against acute infections in mice

1996

We examined the effects of the immunomodulator-adenylate deaminase (E.C. 3.5.4.6) from Penicillium lanoso-viride on experimental mice infections. Prophylactic intraperitoneal administration of adenylate deaminase (ADA) increased survival time and numbers of survivors after infection with Salmonella typhimurium, Pseudomonas aeruginosa and influenza A (H3N2) virus. Protection against influenza virus after intranasal ADA application was also observed. The influence of ADA was time and dose dependent. The most pronounced protection was obtained by administration of 3 U ADA/mice 24 h prior to infection. ADA had no antibiotic effect against these bacterial strains. Protective effects of ADA were …

Salmonella typhimuriumcongenital hereditary and neonatal diseases and abnormalitiesSalmonellamedicine.disease_causeVirusAMP DeaminaseMicrobiologyMicechemistry.chemical_compoundOrthomyxoviridae Infectionsimmune system diseasesCyclosporin amedicineAnimalsMacrophagePseudomonas InfectionsPharmacologyMice Inbred ICRSalmonella Infections AnimalbiologyPseudomonas aeruginosaPenicilliumnutritional and metabolic diseaseshemic and immune systemsbiology.organism_classificationenzymes and coenzymes (carbohydrates)chemistryInfluenza A virusAcute DiseaseImmunologyPenicilliumMice Inbred CBAFemaleNasal administrationTrypan blueImmunopharmacology
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Pandemic influenza A/H1N1 virus in a swine farm house in Sicily, Italy.

2012

This report describes a pandemic A/H1N1 (H1N1 pdm) virus outbreak occurred in December, 2009 in a swine farm used as research facility (Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione) for preclinical studies, located in Sicily, Italy. All the 13 pigs of the farm, showed cough, fever, inappetence and weakness. At the same time, an unvaccinated worker of the stabling showed influenza-like symptoms. RNAv extracted from two swabs collected from infected pigs resulted positive by Real Time RT-PCR for Influenza A virus. Furthermore, after growth on embryonated eggs, viral isolates were identified by Real Time RT-PCR specific for H1N1 pdm virus and characterized antigenically. …

Swine DiseasesReverse Transcriptase Polymerase Chain ReactionSwineA/H1N1 viruReal-Time Polymerase Chain ReactionDisease OutbreaksZoonosisInfluenza A Virus H1N1 SubtypeOrthomyxoviridae InfectionsInfluenza HumanAnimalsHumansSequencingFemalePandemicsSicilyPandemic influenza
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A Trans-amplifying RNA Vaccine Strategy for Induction of Potent Protective Immunity

2019

Here, we present a potent RNA vaccine approach based on a novel bipartite vector system using trans-amplifying RNA (taRNA). The vector cassette encoding the vaccine antigen originates from an alphaviral self-amplifying RNA (saRNA), from which the replicase was deleted to form a transreplicon. Replicase activity is provided in trans by a second molecule, either by a standard saRNA or an optimized non-replicating mRNA (nrRNA). The latter delivered 10- to 100-fold higher transreplicon expression than the former. Moreover, expression driven by the nrRNA-encoded replicase in the taRNA system was as efficient as in a conventional monopartite saRNA system. We show that the superiority of nrRNA- ov…

Translational efficiencyGenetic VectorsRNA-dependent RNA polymeraseHemagglutinin (influenza)Hemagglutinin Glycoproteins Influenza VirusBiologyAntibodies ViralMadin Darby Canine Kidney CellsMice03 medical and health sciencesDogsImmunogenicity VaccineInfluenza A Virus H1N1 Subtype0302 clinical medicineOrthomyxoviridae InfectionsCricetinaeInfluenza HumanDrug DiscoveryGeneticsAnimalsHumansViral Replicase Complex ProteinsRepliconMolecular BiologyGene030304 developmental biologyPharmacologyMice Inbred BALB C0303 health sciencesMessenger RNAVaccinationRNATranslation (biology)Antibodies NeutralizingSemliki forest virusVirologyHEK293 CellsInfluenza Vaccines030220 oncology & carcinogenesisbiology.proteinRNA ViralMolecular MedicineFemaleOriginal ArticleMolecular Therapy
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2014

Pandemic and seasonal influenza viruses cause considerable morbidity and mortality in the general human population. Protection from severe disease may result from vaccines that activate antigen-presenting DC for effective stimulation of influenza-specific memory T cells. Special attention is paid to vaccine-induced CD8+ T-cell responses, because they are mainly directed against conserved internal influenza proteins thereby presumably mediating cross-protection against circulating seasonal as well as emerging pandemic virus strains. Our study showed that influenza whole virus vaccines of major seasonal A and B strains activated DC more efficiently than those of pandemic swine-origin H1N1 and…

education.field_of_studyMultidisciplinaryvirusesViral VaccineOrthomyxoviridaePopulationBiologymedicine.disease_causebiology.organism_classificationVirologyVirusInfluenza A virus subtype H5N1MicrobiologyInfluenza A virusmedicineCytotoxic T celleducationCD8PLOS ONE
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