Search results for "Oso"

Linear Approximation Property, Minkowski Dimension, and Quasiconformal Spheres

1990

Multimode time-dependent gyrotron equations for different time scales

2017

The work of H.K. was supported by the European Regional Development Funding of the Project No. 1.1.1.1/ 16/A/004.

Fundamentals on the Molecular Mechanism of Action of Antimicrobial Peptides

2019

Abstract Antimicrobial peptides (AMPs) are produced by several organisms as their first line of defense. Constituted by amino acids, they may present different mechanisms of action. The antimicrobial activity can be used by the peptide-producing organism itself, as innate immune strategy, or in the industry, applying as natural source preservatives. Understanding the possibilities of the operation of these compounds is a prerequisite for the development of effective uses, as well as for the establishment of combinations, which can even expand their applications considering the possibilities of genetic manipulations. Thus, the objective of this article is to review the basic principles of AM…

Marlies Jansegers, Hacia un enfoque múltiple de la polisemia. Un estudio empírico del verbo multimodal “sentir” desde una perspectiva sincrónica y di…

2019

This article reviews Hacia un enfoque multiple de la polisemia. Un estudio empirico del verbo multimodal “sentir” desde una perspectiva sincronica y diacronica 978 3 11 047470 1

Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs)

2020

[Image: see text] Translational readthrough-inducing drugs (TRIDs) rescue the functional full-length protein expression in genetic diseases, such as cystic fibrosis, caused by premature termination codons (PTCs). Small molecules have been developed as TRIDs to trick the ribosomal machinery during recognition of the PTC. Herein we report a computational study to identify new TRID scaffolds. A pharmacophore approach was carried out on compounds that showed readthrough activity. The pharmacophore model applied to screen different libraries containing more than 87000 compounds identified four hit-compounds presenting scaffolds with diversity from the oxadiazole lead. These compounds have been s…

Computational Study of the Effect of Glyoxal–Sulfate Clustering on the Henry’s Law Coefficient of Glyoxal

2014

We have used quantum chemical methods to investigate the molecular mechanism behind the recently reported ( Kampf , C. J. ; Environ. Sci. Technol . 2013 , 47 , 4236 - 4244 ) strong dependence of the Henry's law coefficient of glyoxal (C2O2H2) on the sulfate concentration of the aqueous phase. Although the glyoxal molecule interacts only weakly with sulfate, its hydrated forms (C2O3H4 and C2O4H6) form strong complexes with sulfate, displacing water molecules from the solvation shell and increasing the uptake of glyoxal into sulfate-containing aqueous solutions, including sulfate-containing aerosol particles. This promotes the participation of glyoxal in reactions leading to secondary organic…

Lidar sounding of volcanic plumes

2013

ABSTRACT Accurate knowledge of gas composition in volcanic plumes has high scientific and societal value. On the one hand, it gives information on the geophysical processes taking place inside volcanos; on the other hand, it provides alert on possible eruptions. For this reasons, it has been suggested to monitor volcanic plumes by lidar. In particular, one of the aims of the FP7 ERC project BRIDGE is the measurement of CO 2 concentration in volcanic gases by differential absorption lidar. This is a very challenging task due to the harsh environment, the narrowness and weakness of the CO 2 absorption lines and the difficulty to procure a suitable laser source. This paper, after a review on r…

Aerosol Chemistry Resolved by Mass Spectrometry: Linking Field Measurements of Cloud Condensation Nuclei Activity to Organic Aerosol Composition.

2016

Aerosol hygroscopic properties were linked to its chemical composition by using complementary online mass spectrometric techniques in a comprehensive chemical characterization study at a rural mountaintop station in central Germany in August 2012. In particular, atmospheric pressure chemical ionization mass spectrometry ((-)APCI-MS) provided measurements of organic acids, organosulfates, and nitrooxy-organosulfates in the particle phase at 1 min time resolution. Offline analysis of filter samples enabled us to determine the molecular composition of signals appearing in the online (-)APCI-MS spectra. Aerosol mass spectrometry (AMS) provided quantitative measurements of total submicrometer or…

Modelling Regional Air Quality in the Canadian Arctic: Simulation of an Arctic Summer Field Campaign

2017

Model simulations of an Arctic summer field campaign were carried out. The model results were compared with observational data from both ground-based monitoring and in situ measurements on-board multiple mobile platforms. The model was able to well capture regional sources and transport affecting the Arctic air quality. It is shown that the study area was impacted by North American (NA) regional biomass burning emissions. The model-observation comparison also corroborates previous findings on possible roles of marine-biogenic sources in aerosol production in the Arctic MBL during summertime.

Developing an indicator-modelling approach to forecast changes in nitrogen critical load exceedance across Europe arising from agricultural reform

2011

International audience; Atmospheric nitrogen (N) deposition above the critical load causes eutrophication with adverse impacts on biodiversity. Average Accumulated critical load Exceedance (AAE) is a measure of the amount of critical load exceedance and the area of habitat which is affected, and has been adopted in Europe as a pressure indicator for biodiversity. In Europe, AAE is calculated by the Coordination Centre for Effects (CCE) of the United Nations Economic Commission for Europe based on modelled nitrogen deposition and country-level reporting of critical load thresholds and ecosystem area. Due to differences in country-level reporting, AAE values for semi-natural habitats may show…