Search results for "Oxazepam"
showing 6 items of 6 documents
Differences in the topographical distribution of EEG activity during surgical anaesthesia and on emergence from volatile anesthetics.
1994
Computerized processing of a 16 channel EEG allows mapping and display of cortical electrical activity in a useful mode for intraoperative monitoring. We studied the topographical distribution of EEG-activity displayed as spectral maps comparing inhalational anaesthesia with isoflurane or enflurane during surgical anaesthesia and emergence. Two groups of nine patients each were anaesthetized with one of the two regimens. The EEG patterns during steady state end-tidal concentrations of isoflurane (0.7-1.1%) or enflurane (0.8-1.3%) showed highest activity in the frontal and occipital areas. At near awakening the frontal and occipital dominance of delta activity disappeared in both groups and …
Low-temperature phosphorescence of 1,4-benzodiazepines
1991
Abstract A highly sensitive method for the low-temperature phosphorescence determination of a series of 1,4-benzodiazepines has been developed. Oxazepam has been used as a test molecule to study the effects of instrumental parameters, such as time decay, gate time, excitation and emission slits, and ordinate, on the phosphorescence spectra. The corresponding analytical parameters have been established for different concentration levels. Under the best sensitivity conditions a limit of detection of 16 parts per trillion (ppt) for oxazepam, 3.8 ppt for medazepam, 2 ppt for prazepam, 5 × 10 −3 ppt for diazepam, and 0.09 ppt for lorazepam could be obtained. The proposed method is thus the most …
MICELLAR LIQUID CHROMATOGRAPHIC DETERMINATION OF ANTI-CONVULSANT DRUGS IN PILLS AND CAPSULES
2000
A simple chromatographic procedure is reported for the determination of several anti-convulsant drugs in pharmaceuticals: carbamazepine, and the benzodiazepines bentazepam, halazepam, oxazepam, pinazepam, and tetrazepam. The procedure utilizes a C18 column, a hybrid micellar mobile phase of 0.1 M SDS-3% butanol-0.1% triethylamine-0.01 M phosphate buffer (pH 3), and UV detection (230 nm). The drugs eluted in less than 13 min, in accordance to their relative polarities, as indicated by their octanol-water partition coefficients. The limits of detection (μg/mL), and intra and inter-day repeatabilities (%), for 4 μg/mL were: carbamazepine (0.03, 1.0, 4.1), bentazepam (0.05, 1.3, 1.6), halazepam…
Characterization of the binding of benzodiazepines to human serum albumin
1973
The binding of eleven benzodiazepine derivatives to human serum albumin (HSA) was determined by means of sephadex gel filtration. The albumin binding of the substances was characterized by the percentage of bound drug, the binding constants k +, K 1 and m, the number of binding sites per albumin molecule, and the free binding energy. Under the conditions chosen in these experiments there seems to exist only one binding site of the same type for all investigated benzodiazepines at the HSA molecule. The affinities of the benzodiazepines to this binding site are very different. It is discussed which part of the benzodiazepine molecule represents the main binding group.
Diazepam has no beneficial effects on stress-induced behavioural and endocrine changes in male tree shrews.
2000
Abstract VAN KAMPEN, M., U. SCHMITT, C. HIEMKE AND E. FUCHS. Diazepam has no beneficial effects on stress-induced behavioural and endocrine changes in male tree shrews. PHARMACOL BIOCHEM BEHAV 65 (3) 539–546, 2000.—The present study evaluated the effect of subchronic oral treatment of psychosocially stressed male tree shrews with diazepam on locomotor activity, marking behavior, avoidance behavior, and urinary cortisol and noradrenaline. To mimic a realistic situation of anxiolytic intervention, the treatment started 14 days after the beginning of psychosocial stress; at that time, the stress-induced behavioral and endocrine alterations had been established. The drug (5 mg/kg/day) was admin…
Influence of pH on the benzodiazepine-human serum albumin complex. Circular dichroism studies.
1974
The influence of pH on the binding of benzodiazepine derivatives to HSA was studied by circular dichroism measurements and by gel filtration. The binding of nearly all benzodiazepines is increased by rising the pH from 6.60 to 8.20. For flurazepam, clonazepam, and nitrazepam this increase in binding is due to an increase of the affinities, while for the other substances the affinity remains constant and the number of binding sites is increased from one to two. The changes in binding of the benzodiazepines by rising the pH are explained by a cationic amino acid residue near or at the benzodiazepine binding site of the HSA molecule. This second binding site is not detectable by circular dichr…