Search results for "Oxazine"

showing 10 items of 128 documents

The effect of tiotropium/olodaterol versus fluticasone propionate/salmeterol on left ventricular filling and lung hyperinflation in patients with COPD

2020

This exploratory, randomised, double-blind, double-dummy, multicentre, cross-over study explored the effect of 6 weeks of treatment with tiotropium/olodaterol (T/O) versus fluticasone propionate/salmeterol (F/S) on left ventricular filling in patients with chronic obstructive pulmonary disease with functional residual capacity (FRC) >120% predicted and postbronchodilator improvement of FRC ≥7.5%. Overall, 76 patients were randomised across nine sites. Treatment with T/O or F/S increased left ventricular end-diastolic volume index from baseline (adjusted mean change: T/O: 2.317 mL/m2, F/S: 2.855 mL/m2), with no statistically significant difference between treatments. However, T/O resulted…

Pulmonary and Respiratory Medicinemedicine.medical_specialtylcsh:MedicineFluticasone propionatePulmonary Disease Chronic Obstructive03 medical and health scienceschemistry.chemical_compound0302 clinical medicineFunctional residual capacityInternal medicinemedicineHumansMulticenter Studies as TopicPlethysmographIn patient1506030212 general & internal medicineTiotropium BromideLunginhaler devicesRandomized Controlled Trials as Topiclcsh:RC705-779COPDCross-Over Studiesbusiness.industrylcsh:ROlodaterollcsh:Diseases of the respiratory systemrespiratory systemmedicine.diseaseFluticasone-Salmeterol Drug CombinationBenzoxazinesBronchodilator Agentsrespiratory tract diseasesrespiratory measurement030228 respiratory systemchemistryPerspectiveCardiologyCOPD pharmacologySalmeterolVentricular fillingbusinessmedicine.drugBMJ Open Respiratory Research
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Synthesis of pyrido[2,1-a]isoquinolin-4-ones and oxazino[2,3-a]isoquinolin-4-ones: New inhibitors of mitochondrial respiratory chain

2013

International audience; Benzo[a]quinolizine is an important heterocyclic framework that can be found in numerous bioactive compounds. The general scheme for the synthesis of these compounds was based on the preparation of the appropriate dihydroisoquinolines by Bischler-Napieralski cyclization with good yields, followed by the Pemberton method to form the oxazinones or pyridones derivatives via acyl-ketene imine cyclocondensation. All the synthesized compounds were assayed in vitro for their ability to inhibit mitochondrial respiratory chain. Most of the tested compounds were able to inhibit the integrated electron transfer chain, measured as NADH oxidation, which includes complexes I, III …

PyridonesStereochemistryImine010402 general chemistryRing (chemistry)01 natural sciencesMitochondria HeartElectron TransportStructure-Activity Relationshipchemistry.chemical_compoundMultienzyme ComplexesFuranOxazinesDrug DiscoveryAnimalsNADH NADPH OxidoreductasesCytotoxicityPharmacologyDose-Response Relationship DrugMolecular Structure[CHIM.ORGA]Chemical Sciences/Organic chemistry010405 organic chemistryOrganic ChemistryQuinolizineBiological activityGeneral MedicineIsoquinolinesElectron transport chain3. Good health0104 chemical sciencesMitochondrial respiratory chainchemistryCattleEuropean Journal of Medicinal Chemistry
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Screening of ecotoxicological, qualitative and reproductive variables in male European sea bassDicentrarchus labrax(L.) reared in three different fis…

2013

The aim of this work was to do a preliminary seasonal screening of ecotoxicological biomarkers in European sea bass Dicentrarchus labrax in three different fish farms, to know if the different location and typology can discriminate them. A set of selected biomarkers of xenobiotic exposure, such as acetylcholinesterase (AChE) activity, Glutathione (GSH) and gonad morphology were investigated seasonally in male European sea bass D. labrax (L.) reared in three different intensive farms: a land-based farm of cement tanks (T), an in-shore sea cages farm (C1) and an off-shore sea cages farm (C2). The results showed that both location and typology can discriminate AChE activity, GSH content and go…

Settore BIO/07 - EcologiaMaleGonadFish farmingZoologyPlant ScienceBiologyEcotoxicologyBiochemistryAnalytical ChemistryAquacultureOxazinesmedicineAnimalsEcotoxicologyEuropean sea bassSea bassbusiness.industryReproductionOrganic Chemistrybiology.organism_classificationaquaculture biomarker fish farm European sea bass ecotoxicologyLipidsFisherymedicine.anatomical_structureaquaculturebiomarkerBassDicentrarchusaquaculture; biomarker; ecotoxicology; European sea bass; fish farmbusinessfish farmNatural Product Research
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CCDC 262066: Experimental Crystal Structure Determination

2006

Related Article: G.Stajer, A.E.Szabo, G.Turos, P.Sohar, R.Sillanpaa|2005|Eur.J.Org.Chem.|2005|4154|doi:10.1002/ejoc.200500155

Space GroupCrystallography811-Methano-12344a7ac8c11c11ac13a-decahydroindolo[17a-a][31]benzoxazine-612-dioneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 262064: Experimental Crystal Structure Determination

2006

Related Article: G.Stajer, A.E.Szabo, G.Turos, P.Sohar, R.Sillanpaa|2005|Eur.J.Org.Chem.|2005|4154|doi:10.1002/ejoc.200500155

Space GroupCrystallography811-Methano-12344a7ac8t11t11ac13a-decahydroindolo[17a-a][31]benzoxazine-612-dioneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1898878: Experimental Crystal Structure Determination

2019

Related Article: Marta Viciano-Chumillas, Jos�� M. Carbonell-Vilar, Donatella Armentano, Joan Cano|2019|Eur.J.Inorg.Chem.|2019|2982|doi:10.1002/ejic.201900323

Space GroupCrystallographyCrystal SystemCrystal Structure(46-bis(diphenylphosphino)-10H-phenoxazine)-bromo-(NN-dimethylformamide)-copper(i)Cell ParametersExperimental 3D Coordinates
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CCDC 742251: Experimental Crystal Structure Determination

2009

Related Article: K.Ejsmont, J.-P.Joly, E.Wenger, B.Guillot, C.Jelsch|2009|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|65|o342|doi:10.1107/S0108270109019544

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters4-Benzoyl-34-dihydro-2H-14-benzoxazine-2-carbonitrileExperimental 3D Coordinates
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CCDC 1907394: Experimental Crystal Structure Determination

2020

Related Article: Nina Arnosti, Fabian Brunner, Isidora Susic, Sarah Keller, José M. Junquera‐Hernández, Alessandro Prescimone, Henk J. Bolink, Michele Sessolo, Enrique Ortí, Catherine E. Housecroft, Edwin C. Constable|2020|Adv.Opt.Mater.|8|1901689|doi:10.1002/adom.201901689

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters[10-benzyl-46-bis(diphenylphosphanyl)-10H-phenoxazine]-(66'-dimethyl-22'-bipyridine)-copper hexafluorophosphate dichloromethane solvateExperimental 3D Coordinates
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CCDC 1907395: Experimental Crystal Structure Determination

2020

Related Article: Nina Arnosti, Fabian Brunner, Isidora Susic, Sarah Keller, José M. Junquera‐Hernández, Alessandro Prescimone, Henk J. Bolink, Michele Sessolo, Enrique Ortí, Catherine E. Housecroft, Edwin C. Constable|2020|Adv.Opt.Mater.|8|1901689|doi:10.1002/adom.201901689

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters[46-bis(diphenylphosphanyl)-10H-phenoxazine]-(6-methyl-22'-bipyridine)-copper hexafluorophosphate dichloromethane solvateExperimental 3D Coordinates
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CCDC 1495998: Experimental Crystal Structure Determination

2017

Related Article: Loránd Kiss, Melinda Nonn, Reijo Sillanpää, Matti Haukka, Santos Fustero, Ferenc Fülöp|2016|Chem.Asian J.|11|3376|doi:10.1002/asia.201601046

Space GroupCrystallographyCrystal SystemCrystal Structureethyl 6-(difluoromethyl)-4-fluoro-2-phenyl-44a5677a-hexahydrocyclopenta[d][13]oxazine-7-carboxylateCell ParametersExperimental 3D Coordinates
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