Search results for "Oxazolidine"
showing 10 items of 31 documents
CCDC 1534673: Experimental Crystal Structure Determination
2017
Related Article: Anders H. Pedersen, Blaise L. Geoghegan, Gary S. Nichol, David W. Lupton, Keith. S. Murray, José Martínez-Lillo, Ian A. Gass, Euan K. Brechin|2017|Dalton Trans.|46|5250|doi:10.1039/C7DT00752C
Stereoselective synthesis and application of tridentate aminodiols derived from (+)-pulegone
2016
Abstract A library of tridentate aminodiols, derived from naturally occurring (R)-(+)-pulegone, was synthesized and applied as chiral catalysts in the addition of diethylzinc to benzaldehyde. The reduction of pulegone furnished pulegol, which was transformed into allylic trichloroacetamide via Overman rearrangement of the corresponding trichloroacetimidate. The protected enamine was subjected to dihydroxylation with OsO4/NMO system resulting in a 1:1 mixture of (1R,2R,4R)- and (1S,2S,4R)-aminodiol diastereomers. After the removal of the trichloroacetyl protecting groups, the obtained primary aminodiols were transformed into secondary ones. The regioselectivity of the ring closure of the N-b…
Colorimetric detection of normetanephrine, a pheochromocytoma biomarker, using bifunctionalised gold nanoparticles.
2019
[EN] A simple and effective colorimetric method for the detection of normetanephrine (NMN), an O-methylated metabolite of norepinephrine, using functionalised gold nanoparticles is described. This metabolite is an important biomarker in the diagnosis of adrenal tumours such as pheocromocytoma or paraganglioma. The colorimetric probe consists of spherical gold nanoparticles (AuNPs) functionalised with two different ligands, which specifically recognize different functional groups in normetanephrine. Thus, a benzaldehyde-terminated ligand was used for the recognition of the amino alcohol moiety in NMN, by forming the corresponding oxazolidine. On the other hand, N-acetyl-cysteine was chosen f…
Chiral Oxazolidine Complexes Derived from Phenolic Schiff Bases
2020
Schiff bases derived from pyridyl- or salicyl-aldehydes and aminoalcohols can evolve to heterocyclic oxazolidines, which in the presence of cations allow the formation of uncommon coordination compounds. In this work, we report new NiII and mixed valence MnII/ MnIV complexes derived from pyridyl oxazolidines and the unprecedented characterization of enantiomerically pure oxazolidines derived from the condensation of o-vanillin with phenylglycinol in the presence of NiII cations. The different reactivity of the pyridinic or phenolic Schiff bases has been compared, and the new systems have been structurally, optically, and magnetically characterized.
Experimental and theoretical DFT study of the reaction of 3-amino-1,2-diols with dichloromethane and paraformaldehyde
2004
Abstract The reactions of 3-phenyl-3-methylamino-1,2-propanediol 1a and 3-[(tert-butyldimethylsilyl)oxy]-1-methylamino-1-phenyl-2-propanol 1b with (CH2O)n and CH2Cl2 are appropriate procedures for the preparation of 1,3-oxazines or 1,3-oxazolidines under proper selection of kinetic or thermodynamic reaction conditions. The reaction of 1b with (CH2O)n or CH2Cl2, affords the oxazolidine 2b under kinetic conditions and then this compound can be slowly converted into 5-[(tert-butyldimethylsilyl)oxy]-3-methyl-4-phenyl-3,4,5,6-tetrahydro-2H-1,3-oxazine 3b under thermodynamic control. The mechanism proposed for this transformation and the effect of polar solvents on the acceleration of the reactio…
Synthesis of chiral oxazolidin-2-ones from N-alkoxycarbonyl amino epoxides: a computational studyElectronic supplementary information (ESI) available…
2002
threo-N-Alkoxycarbonylamino epoxides 5a–d, containing the oxazolidine moiety, were converted into trans-4,5-disubstituted-2-oxazolidin-2-ones 2 with total regio- and stereoselection by means of nucleophilic intramolecular attack of the carbamate moiety to the protonated oxirane ring. Theoretical calculations confirmed both the regioselection and the preference of the cyclocarbamation reaction vs. the intermolecular attack by the solvent, arising from different behaviour in comparison with the analogous iodonium ions.
CCDC 241331: Experimental Crystal Structure Determination
2005
Related Article: M.Brunner, M.Nissinen, T.Straub, K.Rissanen, A.M.P.Koskinen|2005|J.Mol.Struct.|734|177|doi:10.1016/j.molstruc.2004.09.020
CCDC 230045: Experimental Crystal Structure Determination
2005
Related Article: M.Brunner, P.Saarenketo, T.Straub, K.Rissanen, A.M.P.Koskinen|2004|Eur.J.Org.Chem.|2004|3879|doi:10.1002/ejoc.200400207
CCDC 1976455: Experimental Crystal Structure Determination
2020
Related Article: Christian Muhl, Lydia Zengerling, Jonathan Groß, Paul Eckhardt, Till Opatz, Pol Besenius, Matthias Barz|2020|Polym.Chem.|11|6919|doi:10.1039/D0PY01055C
CCDC 243016: Experimental Crystal Structure Determination
2006
Related Article: A.Guirado, R.Andreu, B.Martiz, D.Bautista, C.R.de Arellano, P.G.Jones|2006|Tetrahedron|62|6172|doi:10.1016/j.tet.2006.04.058