Search results for "P P"
showing 10 items of 7770 documents
Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes
2015
The adverse effects to humans and environment of only few chemicals are well known. Absorption, distribution, metabolism, and excretion (ADME) are the steps of pharmaco/toxicokinetics that determine the internal dose of chemicals to which the organism is exposed. Of all the xenobiotic-metabolizing enzymes, the cytochrome P450 (CYP) enzymes are the most important due to their abundance and versatility. Reactions catalyzed by CYPs usually turn xenobiotics to harmless and excretable metabolites, but sometimes an innocuous xenobiotic is transformed into a toxic metabolite. Data on ADME and toxicity properties of compounds are increasingly generated using in vitro and modeling (in silico) tools.…
Mass Hierarchy, Mixing, CP-Violation and Higgs Decay---or Why Rotation is Good for Us
2011
The idea of a rank-one rotating mass matrix (R2M2) is reviewed detailing how it leads to ready explanations both for the fermion mass hierarchy and for the distinctive mixing patterns between up and down fermion states, which can be and have been tested against experiment and shown to be fully consistent with existing data. Further, R2M2 is seen to offer, as by-products: (i) a new solution of the strong CP problem in QCD by linking the theta-angle there to the Kobayashi-Maskawa CP-violating phase in the CKM matrix, and (ii) some novel predictions of possible anomalies in Higgs decay observable in principle at the LHC. A special effort is made to answer some questions raised.
A Comprehensive Mechanism Reproducing the Mass and Mixing Parameters of Quarks and Leptons
2013
It is shown that if, from the starting point of a universal rank-one mass matrix long favored by phenomenologists, one adds the assumption that it rotates (changes its orientation in generation space) with changing scale, one can reproduce, in terms of only six real parameters, all the 16 mass ratios and mixing parameters of quarks and leptons. Of these 16 quantities so reproduced, 10 for which data exist for direct comparison (i.e. the CKM elements including the CP-violating phase, the angles theta(12), theta(13), theta(23) in nu-oscillation, and the masses m(c), m(mu), m(e)) agree well with experiment, mostly to within experimental errors; four others (m(s), m(u), m(d), m(nu 2)), the expe…
Developing the Framed Standard Model
2011
The framed standard model (FSM) suggested earlier, which incorporates the Higgs field and 3 fermion generations as part of the framed gauge theory structure, is here developed further to show that it gives both quarks and leptons hierarchical masses and mixing matrices akin to what is experimentally observed. Among its many distinguishing features which lead to the above results are (i) the vacuum is degenerate under a global $su(3)$ symmetry which plays the role of fermion generations, (ii) the fermion mass matrix is "universal", rank-one and rotates (changes its orientation in generation space) with changing scale $\mu$, (iii) the metric in generation space is scale-dependent too, and in …
Radiative axion inflation
2019
Planck data robustly exclude the simple $\lambda\phi^4$ scenario for inflation. This is also the case for models of Axion Inflation in which the inflaton field is the radial part of the Peccei-Quinn complex scalar field. In this letter we show that for the KSVZ model it is possible to match the data taking into account radiative corrections to the tree level potential. After writing down the 1-loop Coleman-Weinberg potential, we show that a radiative plateau is easily generated thanks to the fact that the heavy quarks are charged under $SU(3)_c$ in order to solve the strong CP problem. We also give a numerical example for which the inflationary observables are computed and the heavy quarks …
A$_{FB}$ in the SMEFT: precision Z physics at the LHC
2021
We study the forward-backward asymmetry $A_{FB}$ in $pp \to \ell^+\ell^-$ at the Z peak within the Standard Model Effective Field Theory (SMEFT). We find that this observable provides per mille level constraints on the vertex corrections of the Z boson to quarks,which close a flat direction in the electroweak precision SMEFT fit. Moreover, we show that current $A_{FB}$ data is precise enough so that its inclusion in the fit improves significantly LEP bounds even in simple New Physics setups. This demonstrates that the LHC can compete with and complement LEP when it comes to precision measurements of the Z boson properties
New Angle on the Strong CP and Chiral Symmetry Problems from a Rotating Mass Matrix
2007
It is shown that when the mass matrix changes in orientation (i.e. rotates) in generation space for a changing energy scale, the masses of the lower generations are not given just by its eigenvalues. In particular, these masses need not be zero even when the eigenvalues are zero. In that case, the strong CP problem can be avoided by removing the unwanted theta term by a chiral transformation not in contradiction with the nonvanishing quark masses experimentally observed. Similarly, a rotating mass matrix may shed new light on the problem of chhiral symmetry breaking. That the fermion mass matrix may so rotate with the scale has been suggested before as a possible explanation for up-down fer…
A solution to the strong CP problem transforming the theta angle to the KM CP-violating phase
2010
It is shown that in the scheme with a rotating fermion mass matrix (i.e. one with a scale-dependent orientation in generation space) suggested earlier for explaining fermion mixing and mass hierarchy, the theta angle term in the QCD action of topological origin can be eliminated by chiral transformations, while giving still nonzero masses to all quarks. Instead, the effects of such transformations get transmitted by the rotation to the CKM matrix as the KM phase giving, for theta of order unity, a Jarlskog invariant typically of order 10(-5), as experimentally observed. Strong and weak CP violations appear then as just two facets of the same phenomenon.
Tevatron Combination of Single-Top-Quark Cross Sections and Determination of the Magnitude of the Cabibbo-Kobayashi-Maskawa Matrix Element Vtb
2015
et al.
Reconciling open charm production at the Fermilab Tevatron with QCD
2005
We study the inclusive hadrodroduction of D^0, D^+, D^{*+}, and D_s^+ mesons at next-to-leading order in the parton model of quantum chromodynamics endowed with universal non-perturbative fragmentation functions (FFs) fitted to e^+e^- annihilation data from CERN LEP1. Working in the general-mass variable-flavor-number scheme, we resum the large logarithms through the evolution of the FFs and, at the same time, retain the full dependence on the charm-quark mass without additional theoretical assumptions. In this way, the cross section distributions in transverse momentum recently measured by the CDF Collaboration in run II at the Fermilab Tevatron are described within errors.