Search results for "P.O.S"
showing 10 items of 5765 documents
Extracellular matrix regulation of PTHrP and PTH/PTHrP receptor in a human breast cancer cell line
1999
AbstractIt was previously reported that 8701-BC breast cancer cells express the gene for parathyroid hormone-related peptide (PTHrP) and its cognate receptor (PTHrP-R), and release immunoreactive PTHrP in the extracellular medium; it was also found that PTHrP, in turn, exerts a role on the proliferative and invasive behavior in vitro of the same cell line. On the other hand, evidence has been produced that adhesion of 8701-BC cells onto different collagen substrates influences in various ways a number of phenotypic expressions, such as cell growth, motility, invasion of reconstituted basement membrane and production of lytic enzymes of the extracellular matrix (ECM). In light of these previ…
Endocannabinoid Role in Synaptic Plasticity and Learning
2009
Endocannabinoids have recently emerged as versatile modulators of synaptic transmission and can act as retrograde neurotransmitters. As they cannot be stored in synaptic vesicles, endocannabinoid signaling is believed to start ‘on-demand,’ via a stimulus-dependent synthesis from membranous precursors at the postsynaptic site. After synthesis, endocannabinoids bind presynaptically to cannabinoid type 1 (CB1) receptors, leading to a short- or long-term suppression of neurotransmitter release. CB1 receptors are present in a plethora of different synaptic connections in the brain. Electrophysiological and behavioral analyses of mutant mice lacking CB1 receptors and of pharmacologically treated …
“Constancia”. Dalla Sicilia a New York un esempio metodologico per la valorizzazione delle collezioni ecclesiastiche
2022
Il contributo si offre come proposta metodologica ai fini della valorizzazione delle collezioni diocesane partendo dall’esperienza della mostra “Constancia. Donne al potere nell’impero mediterraneo di Federico II”, curata dagli autori, insieme alla prof. Di Natale, all’Istituto Italiano di Cultura di New York nei mesi di marzo e aprile 2022. Il testo illustra il percorso che ha condotto all’elaborazione del progetto curatoriale, a partire dall’ottavo centenario della morte di Costanza d’Aragona cui sono state correlate altre tre Costanza rispettivamente madre, figlia e nipote di Federico II di Svevia, offrendo così un originale taglio al femminile e un resoconto delle quattro donne al poter…
The pain threshold of high-threshold mechanosensitive receptors subsequent to maximal eccentric exercise is a potential marker in the prediction of D…
2017
Background Delayed-onset muscle soreness (DOMS) refers to dull pain and discomfort in people after participating in exercise, sport or recreational physical activities. The aim of this study was to detect underlying mechanical thresholds in an experimental model of DOMS. Methods Randomised study to detect mechanical pain thresholds in a randomised order following experimentally induced DOMS of the non-dominant arm in healthy participants. Main outcome was the detection of the pressure pain threshold (PPT), secondary thresholds included mechanical detection (MDT) and pain thresholds (MPT), pain intensity, pain perceptions and the maximum isometric voluntary force (MIVF). Results Twenty volun…
Frequency and Correlates of Mild Cognitive Impairment in Myasthenia Gravis
2023
Background: Antibodies against acetylcholine receptors (AChRs) can also target nicotinic AChRs that are present throughout the central nervous system, thus leading to cognitive dysfunctions in patients with myasthenia gravis (MG). However, the presence of cognitive impairment in MG is controversial, and the factors that may influence this risk are almost completely unknown. In this study, the frequency of mild cognitive impairment (MCI) in MG, as well as the clinical, immunological, and behavioral correlates of MCI in MG were evaluated. Methods: A total of 52 patients with MG underwent a comprehensive assessment including motor and functional scales, serological testing, and neuropsychologi…
Associations of physical performance and physical activity with mental well-being in middle-aged women
2021
Abstract Background To investigate whether physical performance is independently of physical activity (PA) associated with positive and negative dimensions of mental well-being in middle-aged women. Methods Data were drawn from the Estrogenic Regulation of Muscle Apoptosis (ERMA) study in which women 47 to 55 years were randomly selected from the Finnish National Registry. They (n = 909) participated in measurements of physical performance (handgrip force, knee extension force, vertical jumping height, maximal walking speed, and six-minute walking distance). Both mental well-being (the Centre for Epidemiologic Studies Depression Scale, the International Positive and Negative Affect Schedule…
Women and Demons in the Late Medieval Wall Paintings in the Church of Espoo (Finland)
2017
The late-medieval stone church of Espoo (county of Uusimaa), situated on the south coast close to the current-day capital of Finland, Helsinki, displays a wealth of medieval wall paintings executed around the 1510s by a group of painters that has remained anonymous. In the fourth vault of the north aisle a demon has been depicted as the proxy and associate of women who are seen in typical household tasks of milking and churning. On the west wall above the entrance a depiction shows a demon passing a pair of shoes to a woman, and above, three demons are seen twiddling with a parchment. This article analyses the images and places them in the context of social control that aimed at regulating …
Ferritin-Coated SPIONs as New Cancer Cell Targeted Magnetic Nanocarrier
2023
Superparamagnetic iron oxide nanoparticles (SPIONs) may act as an excellent theragnostic tool if properly coated and stabilized in a biological environment, even more, if they have targeting properties towards a specific cellular target. Humanized Archaeoglobus fulgidus Ferritin (HumAfFt) is an engineered ferritin characterized by the peculiar salt-triggered assembly-disassembly of the hyperthermophile Archaeoglobus fulgidus ferritin and is successfully endowed with the human H homopolymer recognition sequence by the transferrin receptor (TfR1 or CD71), overexpressed in many cancer cells in response to the increased demand of iron. For this reason, HumAfFt was successfully used in this stud…
Mechanisms of cell death in canine parvovirus-infected cells provide intuitive insights to developing nanotools for medicine
2010
Jonna Nykky, Jenni E Tuusa, Sanna Kirjavainen, Matti Vuento, Leona GilbertNanoscience Center and Department of Biological and Environmental Science, University of Jyväskylä, FinlandAbstract: Viruses have great potential as nanotools in medicine for gene transfer, targeted gene delivery, and oncolytic cancer virotherapy. Here we have studied cell death mechanisms of canine parvovirus (CPV) to increase the knowledge on the CPV life cycle in order to facilitate the development of better parvovirus vectors. Morphological studies of CPV-infected Norden laboratory feline kidney (NLFK) cells and canine fibroma cells (A72) displayed characteristic apoptotic events. Apoptosis was f…
Nepilngadīgo tiesības uz ārstniecību aizsardzības kontekstā
2015
Bakalaura darbs „Nepilngadīgo tiesības uz ārstniecību aizgādības kontekstā” izstrādāts saskatot pretrunas normatīvajos aktos, kas regulē nepilngadīgo tiesības un viņu likumisko pārstāvju pienākumus nepilngadīgo ārstniecībā. Bakalaura darba mērķis ir izpētīt nepilngadīgo un viņu likumisko pārstāvju savstarpējās tiesiskās attiecības nepilngadīgo tiesību uz ārstniecību realizēšanā kopsakarā ar normatīvajos aktos noteiktajām ārstniecības iestādes/personas tiesībām un pienākumiem. Autore izvirzīja šādus uzdevumus mērķa sasniegšanai: izpētīt nepilngadīgo tiesības ārstniecībā, to realizēšanas iespējas aizgādības kontekstā, likumdevēja piešķirto rīcībspējas apjomu nepilngadīgajiem, likumisko pārstā…