Search results for "P300"

Rubinstein-Taybi syndrome (CREBBP, EP300)

2011

1.2 OMIM# of the disease180849.1.3 Name of the analyzed genes or DNA/chromosome segmentsCREBBP, EP300 (E1A binding protein p300).1.4 OMIM# of the genes600140 (CREBBP), 602700 (EP300).1.5 Mutational spectrumMainly frameshift, nonsense, splice site and missense mutations. Lessfrequently large deletions (one or more exons) and rarely balancedinversions and translocations. Mutations are heterozygous, and mosaicmutations have been described. At present, more than 100 pathogenicmutations are known for the two genes together, but mutations inEP300 are much less common (only 11 so far).

Tissue-specific mosaicism in a patient with Rubinstein–Taybi syndrome and CREBBP exon 1 duplication

2019

Inhibition of VEGF expression through blockade of Hif1a and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer c…

2013

Background: Hepatocellular carcinoma (HCC) growth relies on angiogenesis via vascular endothelial growth factor (VEGF) release. Hypoxia within tumour environment leads to intracellular stabilisation of hypoxia inducible factor 1 alpha (Hif1α) and signal transducer and activator of transcription (STAT3). Melatonin induces apoptosis in HCC, and shows anti-angiogenic features in several tumours. In this study, we used human HepG2 liver cancer cells as an in vitro model to investigate the anti-angiogenic effects of melatonin. Methods: HepG2 cells were treated with melatonin under normoxic or CoCl2-induced hypoxia. Gene expression was analysed by RT–qPCR and western blot. Melatonin-induced anti-…

P300-based brain computer interface experimental setup

2009

A Brain-Computer interface (BCI) is a communication system that enables the generation of a control signal from brain signals such as sensorymotor rhythms and evoked potentials; therefore, it constitutes a novel communication option for people with severe motor disabilities (such as Amyotrophic Lateral Sclerosis patients). This paper presents the development of a P300-based BCI. This prototype uses a homemade six-channel electroencephalograph for the acquisition of the signals, and a visual stimulation matrix; since this matrix contains letters of the alphabet as well as images associated to them, it permits word-writing and the elaboration of messages with the images. To process the signal…

Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1α

2007

We reported previously that the obesity hormone leptin is overexpressed in breast cancer biopsies. Here, we investigated molecular mechanisms involved in this process, focusing on conditions that are associated with obesity, that is, hyperinsulinemia and induction of hypoxia. By using quantitative real-time PCR, immunofluorescent detection of proteins and enzyme-linked immunosorbent assays, we found that treatment of MCF-7 breast cancer cells with high doses of insulin or the hypoxia-mimetic agent CoCl2, or culturing the cells under hypoxic conditions significantly increased the expression of leptin mRNA and protein. Notably, the greatest leptin mRNA and protein expression were observed und…

Gender, voice and space: Feminism online

2018

This paper addresses the highly topical, rapidly developing subject of feminism in contemporary society. Topics that have long been the concern of feminists - such as violence and harassment, the gender pay gap, and women?s suffrage - are currently receiving a level of media attention that suggests a new feminist movement that some might depict as a ?third or fourth ?wave.? However, arguing for a more sceptical and historically-grounded approach, positing that we should maintain a critical eye on popular and media depictions of feminism, this paper highlights the contours of feminist activism which indicate significant continuity in terms of feminist concerns over recent decades. The paper …

P300 amplitudes in the Concealed Information Test are less affected by depth of processing than electrodermal responses

2012

The Concealed Information Test (CIT) has been used in the laboratory as well as in field applications to detect concealed crime related memories. The presentation of crime relevant details to guilty suspects has been shown to elicit enhanced N200 and P300 amplitudes of the event-related brain potentials (ERPs) as well as greater skin conductance responses (SCRs) as compared to neutral test items. These electrophysiological and electrodermal responses were found to incrementally contribute to the validity of the test, thereby suggesting that these response systems are sensitive to different psychological processes. In the current study, we tested whether depth of processing differentially af…

Event related brain potential (ERP) correlates of activation and effort in state regulation among children with attentional problems

2002

Neurophysiological markers of subjective memory complaints in healthy people

2022

Con el envejecimiento de la población es importante comprender los cambios neurofisiológicos que se producen. En este contexto, las quejas subjetivas de la memoria (QSM) se están convirtiendo en un tema de interés ya que se han considerado un factor de riesgo para desarrollar trastornos relacionados con demencias como el deterioro cognitivo leve y enfermedad de Alzheimer. Por lo tanto, es importante investigar los biomarcadores tempranos para la detección y la planificación de los tratamientos. En este sentido, el procesamiento de emociones faciales es una importante función cognitiva comúnmente afectada en personas con trastornos relacionados con demencias que podría ayudar a analizar camb…

Emotional modulation of the attentional blink and the relation to interpersonal reactivity

2013

The extent of the attentional blink effect on detection rates in rapid serial visual presentations is modulated by the emotionality of the stimuli. Emotionally salient stimuli are detected more often, even if presented in the attentional blink period, and elicit an enlarged P3 response, which has been interpreted as enhanced consolidation. This effect correlates with individual differences in trait affectivity such as anxiety or dysphoria. Here, we ask if it is also related to the capacity to detect emotions in others, i.e., to interpersonal social traits. We therefore presented emotional and neutral images depicting social scenes as targets in an attentional blink design and measured detec…