Search results for "PAB"

Heavy metal ion induction of adhesion molecules and cytokines in human endothelial cells: the role of NF-kappaB, I kappaB-alpha and AP-1.

1997

We analyzed the influence of heavy-metal ions on human umbilical vein endothelial cells (HUVEC) in comparison to proinflammatory cytokines (TNF-alpha, IL-1beta) and lipopolysaccharide (LPS). Adhesion molecule and cytokine expressions are upregulated by heavy-metal exposure. Expression of E-selectin on the cell surface was strongly induced by 1-mM concentrations of NiCl2 and CoCl2, whereas ZnCl2 and CrCl3 had no influence. Furthermore, it is shown that NiCl2 induces mRNA expression of E-selectin, intercellular adhesion molecule-1, IL-6 and IL-8 in a 1-mM concentration. The transcription factor NF-kappaB is known to be involved in the regulation of adhesion molecule expression in endothelial …

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Responsible I(m)ovation in Asia Pacific regions

2022

AbstractOver the past 20 years, a debate has developed on the differences between innovation and imitation strategies as mechanisms by which businesses operating in the Asia Pacific region may gain a competitive advantage. The current research contributes to this debate from a different perspective by exploring some of the challenges and opportunities associated with the combination of both strategies into what has been defined as imovation. Imovators and imovations do not stand alone in business ecosystems. Rather, they should be embraced in the context of sustainability-related virtues and emerging capabilities, such as ethical behaviour, co-responsibility and positive social impact. Taki…

The Effects of New Emerging Technologies on Human Resources : Emergence of Industry 4.0, a Necessary Evil?

2017

Master's thesis Business Administration BE501 - University of Agder 2017 Based on dynamic capability theory and existing literature, the study empirically investigates the effects of new emerging technologies on human resources; to know if the emergence of Industry 4.0 is a necessary evil or not. Descriptive research design with deductive qualitative analysis (DQA) method was used to analyse data obtained from 6 companies in Norway. Consistent with the two hypotheses deduced in our study, results confirmed in the first place that new emerging technologies have positive effect on human resources productivity. Secondly, new emerging technologies have potential negative challenges on human res…

Exploring the relationship between big data analytics capability and competitive performance : The mediating roles of dynamic and operational capabil…

2020

A central question for information systems (IS) researchers and practitioners is if, and how, big data can help attain a competitive advantage. To address this question, this study draws on the resource-based view, dynamic capabilities view, and on recent literature on big data analytics, and examines the indirect relationship between a firm’s big data analytics capability (BDAC) and competitive performance. The study extends existing research by proposing that BDACs enable firms to generate insight that can help strengthen their dynamic capabilities, which, in turn, positively impact marketing and technological capabilities. To test our proposed research model, we used survey data from 202…

THE DEVELOPMENT OF THE RESOURCE BASED FIRM BETWEEN VALUE APPROPRIATION AND VALUE CREATION

2005

Various authors have brought forth the idea that the increase in context turbulence and the relentless change in today’s economic and competitive environments have rendered it essential for an effective firm strategy to combine both value appropriation and value creation (Porter, (1996); Moran & Ghoshal, (1999); Venkataraman & Sarasvathy, (2001); Hitt et al., (2001b). Nonetheless, the methodological bases and the assumptions that characterize contributions concerning value appropriation and value creation are notably different and in many respects opposite to one another. These profound methodological differences hinder the possibility of a combined consideration of value appropriation and …

How technology-based firms become also highly innovative firms? The role of knowledge, technological and managerial capabilities, and entrepreneurs’ …

2019

To what extent is the likelihood that a Technology-Based Firm – TBF – turns into a Technology-Based and Highly Innovative Firm – TB&InnF – is influenced by technical capabilities or managerial capabilities and education background? We analyse this question using a novel data panel assembled for 326 Spanish industrial firms, along the period 1998–2014. Our findings show the probability of becoming a TB&InnF growths when firms are able to accumulate a high endowment of knowledge and technological capabilities, and a managerial team with experience, a strong power position and previous technical or managerial education background. Results also indicate the CEO's educational profile in manageme…

Post-entry internationalisation activity of retailers

2013

Purpose – The purpose of this paper is to propose a framework, based on empirical research, to explain the strategic processes of post-entry development in international retailing through consideration of the dynamic capabilities attributable to retailers. Design/methodology/approach – Case study approach of five international retail firms using secondary data and primary data gathered through interviews with firms ' executives and financial analysts. Findings – The research findings, in the light of the existing literature, suggest a framework that makes a distinction between first level or generic dynamic capabilities relevant to the internationalization process and second level or speci…

L'intention en droit pénal : une notion introuvable ?

2001

International audience

A holistic perspective on the theoretical foundations for ICT4D research

2018

While many theories have guided research Information and Communication Technologies for Development (ICT4D), we are yet to construct a clear and coherent narrative that would help us answer the question of how ICT fosters development in underdeveloped communities. In this paper, we argue that one of the main reasons for this is that our holistic understanding of ICT4D is seldom grounded in theories to understand the core areas that define the field, namely, ICT, Development, and, ‘4’ which are the transformative processes that link the two. Through a brief literature review, we list theories that have informed ICT4D research in each of these areas. We present examples of theories, namely, C…