Search results for "PAM"
showing 10 items of 1768 documents
Neurotransmitters and Behavioral Alterations Induced by Nickel Exposure.
2020
Background:: Nickel ions (Ni2+) are a heavy metal with wide industrial uses. Environmental and occupational exposures to Ni are potential risk factors for brain dysfunction and behavioral and neurological symptoms in humans. Methods: We reviewed the current evidence about neurochemical and behavioral alterations associated with Ni exposure in laboratory animals and humans. Results: Ni2+ exposure can alter (both inhibition and stimulation) dopamine release and inhibit glutamate NMDA receptors. Few reports claim an effect of Ni2+ at the level of GBA and serotonin neurotransmission. At behavioral levels, exposure to Ni2+ in rodents alters motor activity, learning and memory as well as anxiety…
A Stage-Based Approach to Therapy in Parkinson’s Disease
2019
Parkinson’s disease (PD) is a neurodegenerative disorder that features progressive, disabling motor symptoms, such as bradykinesia, rigidity, and resting tremor. Nevertheless, some non-motor symptoms, including depression, REM sleep behavior disorder, and olfactive impairment, are even earlier features of PD. At later stages, apathy, impulse control disorder, neuropsychiatric disturbances, and cognitive impairment can present, and they often become a heavy burden for both patients and caregivers. Indeed, PD increasingly compromises activities of daily life, even though a high variability in clinical presentation can be observed among people affected. Nowadays, symptomatic drugs and non-phar…
Current disease modifying approaches to treat Parkinson's disease
2015
Parkinson's disease (PD is a progressive neurological disorder characterized by the degeneration and death of midbrain dopamine and non-dopamine neurons in the brain leading to motor dysfunctions and other symptoms, which seriously influence the quality of life of PD patients. The drug L-dopa can alleviate the motor symptoms in PD, but so far there are no rational therapies targeting the underlying neurodegenerative processes. Despite intensive research, the molecular mechanisms causing neuronal loss are not fully understood which has hampered the development of new drugs and disease-modifying therapies. Neurotrophic factors are by virtue of their survival promoting activities attract candi…
2017
The mammalian retina harbors a circadian clockwork that regulates vision and promotes healthiness of retinal neurons, mainly through directing the rhythmic release of the neurohormones dopamine-acting on dopamine D4 receptors-and melatonin-acting on MT1 and MT2 receptors. The gene Gnaz-a unique Gi/o subfamily member-was seen in the present study to be expressed in photoreceptors where its protein product Gαz shows a daily rhythm in its subcellular localization. Apart from subcellular localization, Gnaz displays a daily rhythm in expression-with peak values at night-in preparations of the whole retina, microdissected photoreceptors and photoreceptor-related pinealocytes. In retina, Gnaz rhyt…
Glutamate and opioid antagonists modulate dopamine levels evoked by innately attractive male chemosignals in the nucleus accumbens of female rats
2017
Sexual chemosignals detected by vomeronasal and olfactory systems mediate intersexual attraction in rodents, and act as a natural reinforcer to them. The mesolimbic pathway processes natural rewards, and the nucleus accumbens receives olfactory information via glutamatergic projections from the amygdala. Thus, the aim of this study was to investigate the involvement of the mesolimbic pathway in the attraction toward sexual chemosignals. Our data show that female rats with no previous experience with males or their chemosignals display an innate preference for male-soiled bedding. Focal administration of the opioid antagonist b-funaltrexamine into the posterior ventral tegmental area does no…
Ocular Clocks: Adapting Mechanisms for Eye Functions and Health
2018
Vision is a highly rhythmic function adapted to the extensive changes in light intensity occurring over the 24-hour day. This adaptation relies on rhythms in cellular and molecular processes, which are orchestrated by a network of circadian clocks located within the retina and in the eye, synchronized to the day/night cycle and which, together, fine-tune detection and processing of light information over the 24-hour period and ensure retinal homeostasis. Systematic or high throughput studies revealed a series of genes rhythmically expressed in the retina, pointing at specific functions or pathways under circadian control. Conversely, knockout studies demonstrated that the circadian clock re…
Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
2014
Objective Mounting evidence suggests that α-synuclein, a major protein component of Lewy bodies (LB), may be responsible for initiating and spreading the pathological process in Parkinson disease (PD). Supporting this concept, intracerebral inoculation of synthetic recombinant α-synuclein fibrils can trigger α-synuclein pathology in mice. However, it remains uncertain whether the pathogenic effects of recombinant synthetic α-synuclein may apply to PD-linked pathological α-synuclein and occur in species closer to humans. Methods Nigral LB-enriched fractions containing pathological α-synuclein were purified from postmortem PD brains by sucrose gradient fractionation and subsequently inoculate…
Kokkeja, kajuuttavahteja ja oppilaita : miehistön nuorimmat jäsenet oululaisilla ja raahelaisilla purjealuksilla 1850 - 1860 -luvuilla
2012
Pro gradun tarkoituksena on selvittää oululaisten ja raahelaisten kauppa-alusten miehistön nuorimpien jäsenten merille lähtöä ja urakehitystä ensimmäisen viiden vuoden aikana. Työn tavoitteena on selvittää, minkä ikäisiä olivat nuoret merimiehet, millaiset sosiaaliset lähtökohdat heillä oli, miksi he pestautuivat, millaista elämä oli laivalla ja miten heidän uransa kehittyi jatkossa. Tarkastelu kohdistuu viiden vuoden jaksolle vuosina 1858-1863 ja mahdollisuuksien mukaan joidenkin miesten uraa on seurattu pidemmälti. Tutkimus edustaa kollektiivibiografista ja mikrohistoriallista tutkimusotetta. Tutkittavasta joukosta, 75 nuoresta miehestä, on luotu tietokantoja, joiden avulla selvitetään, m…
Kustību rotaļa kā pārvietošanās pamatkustību pilnveidotāja 2-3 gadus veciem bērniem
2021
Nosaukums: Kustību rotaļa kā pārvietošanās pamatkustību pilnveidotāja 2-3 gadus veciem bērniem. Autore: Marina Stražinska Zinātniskā darba vadītāja: Mg. izgl. zin. Agita Klempere- Sipjagina Šajā kvalifikācija darbā tika teorētiski pētīta kustību rotaļa kā pārvietošanās pamatkustību pilnveidotāja pirmsskolā. Tika izpētīta konkrētā vecuma posma bērna attīstība un attīstības īpatnības. Darba pirmā nodaļa teorētiski raksturotas pamatkustības. Otrajā nodaļā teorētiski raksturotas 2-3 gadus vecu bērnu psiho-fizioloģiskās attīstības īpatnības. Trešajā nodaļā tika teorētiski pētīta rotaļu būtība un kustību rotaļas nozīme 2-3 gadus vecu bērnu pamatkutību pilnveidošana. Empīriskajā pētījumā tika izzi…
Estudio de la función de los factores de transcripción PBX en la diferenciación a neurona dopaminérgica del bulbo olfatorio de ratón
2017
[EN] Dopamine signalling regulates a variety of complex behaviours and defects in dopaminergic neuron function or survival result in severe human pathologies such as Parkinson´s disease. All dopaminergic neurons are characterized by the expression of a battery of genes that code for a set of proteins required for the synthesis, release and re-uptake of dopamine and all together are called the DA pathway genes. Therefore, understanding how this set of genes are transcriptionally activated in a coordinated manner is the first step to discover the clues of dopaminergic terminal differentiation. The dopamine pathway genes are highly conserved throughout evolution. Studies in the nematode C.eleg…