Search results for "PAM"
showing 10 items of 1768 documents
In vitro synthesis of dopamine and noradrenaline in the isolated rat pineal gland: day-night variations and effects of electrical stimulation.
1989
: Isolated rat pineal glands were incubated in vitro in a medium containing [I4C]dopamine or [14C]tyrosine, and the tissue contents of l4C-labelled and total dopamine and noradrenaline were determined by HPLC followed by electrochemical detection and scintillation spectrometry. During incubation with [l4C]dopamine, the labelled amine accumulated in pineal glands and was partially converted into [l4C]noradrenaline. Nomifensine, a neuronal amine uptake blocker, largely inhibited the accumulation of [l4C]dopamine and the formation of [14C]noradrenaline. These experiments demonstrated dopamine β-hydroxylase activity in the sympathetic nerves of the pineal gland. During incubation with [14C]tyro…
Relaxation induced by N-terminal fragments of chromogranin A in mouse gastric preparations.
2007
Abstract A definitive role for chromogranin A (CGA)-derived fragments in the control of the gastrointestinal smooth muscle contractility has not been yet established. The purpose of the present study was to evaluate, in vitro , the effects of the recombinant vasostatin 1–78 (VS-1), CGA 7–57 and CGA 47–66 on the mouse gastric mechanical activity, recording the changes of intraluminal pressure. VS-1, CGA 7–57 and CGA 47–66 produced concentration-dependent relaxations. Mouse anti-vasostatin-1 monoclonal antibody 5A8, recognising the region 53–57, abolished the relaxation induced by VS-1, indicating the specificity of the effect. The relaxation was significantly reduced by tetrodotoxin (TTX), b…
Pituitary resistance to thyroid hormone action with preserved circadian rhythm of thyrotropin in a postmenopausal woman.
1992
We assessed the 24-h behavior of circulating TSH and the dopaminergic control on TSH release in a postmenopausal woman, who had elevated levels of serum thyroid hormones and an inappropriately high concentration of serum TSH, indicating pituitary resistance to thyroid hormone action. The patient was found to have a daily profile of serum TSH similar to that of normal subjects, except for the persistently elevated 24 h levels, suggesting that alterations in thyroid hormone negative feedback control did not affect substantially circadian TSH rhythm. The acute administration of a dopamine antagonist drug (metoclopramide) resulted in a markedly elevated peak of serum TSH, similar both in the mo…
Context dependent variation in corticosterone and phenotypic divergence of Rana arvalis populations along an acidification gradient
2022
Background Physiological processes, as immediate responses to the environment, are important mechanisms of phenotypic plasticity and can influence evolution at ecological time scales. In stressful environments, physiological stress responses of individuals are initiated and integrated via the release of hormones, such as corticosterone (CORT). In vertebrates, CORT influences energy metabolism and resource allocation to multiple fitness traits (e.g. growth and morphology) and can be an important mediator of rapid adaptation to environmental stress, such as acidification. The moor frog, Rana arvalis, shows adaptive divergence in larval life-histories and predator defense traits along an acidi…
Reto endokrīno slimību sastopamība stacionēto pacietu populācijā
2017
Problēmas būtība. Retās slimības ir dzīvību apdrаudošas vai hrоniski novājinošas slimības, kam rаksturīga zema izplatība bet augsta komplicētības pakāpe. Eiropas Savienībā, kā arī Latvijā, slimība tiek uzskatīta par retu, ja tā skаr ne vairāk kā 5 no 10 000 (1 no 2000) cilvēkiem. Šobrīd Latvijā ir aptuveni 2 miljoni iedzīvotāju, tātad mūsu valstī absolūtos skaitļos retas slimības skaitās tās, ar kurām slimo ne vairāk kā 1000 cilvēki. Sakarā ar to, ka Latvijā nepastāv vienotas reto slimību uzskaites sistēmas, tai skaitā reto endokrīno slimību reģistra, netiek veikta šādu pacientu uzskaite kā arī sastopamības un diagnosticēšanas tendences analīze, un līdz ar to visticamāk Latvijā ir daudz ned…
A Reassessment of the Therapeutic Potential of a Dopamine Receptor 2 Agonist (D2-AG) in Endometriosis by Comparison against a Standardized Antiangiog…
2021
Dopamine receptor 2 agonists (D2-ags) have been shown to reduce the size of tumors by targeting aberrant angiogenesis in pathological tissue. Because of this, the use of a D2-ag was inferred for endometriosis treatment. When assayed in mouse models however, D2-ags have been shown to cause a shift of the immature vessels towards a more mature phenotype but not a significant reduction in the amount of vascularization and size of lesions. These has raised concerns on whether the antiangiogenic effects of these compounds confer a therapeutic value for endometriosis. In the belief that antiangiogenic effects of D2-ags in endometriosis were masked due to non-optimal timing of pharmacological inte…
Efectos del tratamiento con agonistas dopaminérgicos sobre las lesiones endometriósicas
2014
La prolactina (PRL) es una hormona hipofisaria que desempeña un papel fundamental en diversas funciones reproductivas, fundamentalmente en la lactancia. En situaciones patológicas que están relacionadas con la presencia de adenomas hipofisarios o ingesta de fármacos psicotropos, los niveles de PRL están elevados y afectan a la función gonadal, pues inhiben la secreción de hormonas hipofisarias como la LH o FSH, ocasionando amenorrea (9%), galactorrea (25%) o ambas (70%) (1).La hiperprolactinemia, por lo tanto, es una causa frecuente de infertilidad por anovulación (2). Por otro lado, la endometriosis es una importante entidad patológica ginecológica estrógeno dependiente cuya prevalencia en…
Evaluación estandarizada del potencial antiangiógénico del agonista dopaminérgico en el tratamiento de la endometriosis
2018
La endometriosis es una enfermedad crónica, de elevada prevalencia y etiopatogenia no claramente establecida, para la que no se dispone, actualmente, de un tratamiento seguro y eficaz a largo plazo. El establecimiento de la angiogénesis como uno de los requisitos fundamentales en la implantación y desarrollo de la enfermedad ha llevado a considerar los fármacos antiangiogénicos como una potencial diana terapéutica. Estos compuestos han demostrado, en modelos animales, reducir el tamaño de las lesiones endometriales; sin embargo, el uso de estos compuestos en humanos se ve limitado por el intolerable perfil de efectos secundarios que presenta. Los agonistas dopaminérgicos (fármacos con un pe…
Evaluación de la accesibilidad de los servicios sanitarios de atención primaria en el municipio de Valencia
2012
Un análisis que consista en evaluar la accesibilidad a los equipamientos sanitarios implica, principalmente la oferta de los mismos por parte de las administraciones y puede ser abordado desde diversas perspectivas. Nos interesa la visión geográfica, en la que se hace especial mención a la localización y distribución, y por otra parte la visión social, que apunta a que esa visión de los servicios prestados debe ser equitativa para satisfacer a la población y mejorar la calidad de vida. An analysis that consists of evaluating the accessibility of health facilities involves mainly supply them by the government and can be approached from different perspectives. We are interested in the geograp…
Ergonomijas pamatprincipu ievērošana pacientu aprūpē intensīvās terapijas nodaļā
2016
Bakalaura darba tēma ir ‘’Ergonomijas pamatprincipu ievērošana pacientu aprūpē, intensīvās terapijas nodaļā’’. Tēmas aktualitāti nosaka tas, ka māsas ikdienas darbs ir saistīts ar pacientu aprūpi, kas ir fiziski un psiholoģiski smags darbs. Lai, māsa nodrošinātu pacientam sekmīgu un kvalitatīvu ārstēšanās procesa gaitu un iznākumu, nepieciešams ievērot pareizus ergonomijas pamatprincipus. Ergonomijas pamatprincipi tiek balstīti uz muskuļu kustību fizioloģiju, pareizas pozas ieņemšanu, celšanas tehniku, pozicionēšanu, pārvietošanu, kā arī darba aprīkojuma un palīgierīču pareizu lietošanu. Ievērojot šos principus, ir iespējams mazināt kļūdas, kuras var tikt pieļautas darbā, tā ir iespēja mazi…