Search results for "PAM"

Comprehensive analysis of forty yeast microarray datasets reveals a novel subset of genes (APha-RiB) consistently negatively associated with ribosome…

2014

This article has been made available through the Brunel Open Access Publishing Fund. Background: The scale and complexity of genomic data lend themselves to analysis using sophisticated mathematical techniques to yield information that can generate new hypotheses and so guide further experimental investigations. An ensemble clustering method has the ability to perform consensus clustering over the same set of genes from different microarray datasets by combining results from different clustering methods into a single consensus result. Results: In this paper we have performed comprehensive analysis of forty yeast microarray datasets. One recently described Bi-CoPaM method can analyse express…

Salsolinol and ethanol-derived excitation of dopamine mesolimbic neurons: new insights

2013

Evidence supporting the essential role of brain-derived ethanol metabolites in the excitation of dopamine (DA) midbrain neurons has multiplied in the last 10–15 years. The pioneer and influential behavioral studies by CM Aragon and colleagues (see Correa et al., 2012 for a complete review) and more recent data (Sanchez-Catalan et al., 2009; Marti-Prats et al., 2010, 2013) have repeatedly demonstrated the crucial role displayed by acetaldehyde (ACD) in the locomotor and other behavioral responses elicited by ethanol. Although these experiments mainly used an indirect measure (exploratory locomotion) as an index of the excitation of DA neurons in the ventral tegmental area (VTA), results stro…

Mucosal immunology and probiotics.

2013

The cross-talk between the mucosa-associated immune system and microbiota is critical in mucosal tissue homeostasis as well as in protection against infectious and inflammatory diseases occurring at mucosal sites. This recent evidence has paved the way to therapeutic approaches aimed at modulating the mucosa-associated immune system using probiotics. Different strains of probiotics possess the ability to finely regulate dendritic cell (DC) activation, polarizing the subsequent T cell activity toward Th1 (e.g. Lactobacillus (Lb) acidophilus), Th2 (Lb.reuteri and Bifidobacterium bifidum) or, as more recently demonstrated, Th17 responses induced by specific strains such as Lb.rhamnosus GG and …

Nota minima sul comodato c.d. ad pompam vel ostentationem

2016

On the basis of the exegesis of certain texts in the Justinian’s Digest, namely 13.6.3.6 (Ulp. 28 ad ed.), 12.1.18.1 (Ulp. 7 disp.), 13.6.4 (Gai. 1 de verb. obl.), 46.3.67 (Marc. 13 dig.), the Author formulates some considerations on the commodatum so-called ad pompam vel ostentationem, pointing out that the applications related to that anomalous commodatum were more complex and not merely confined to the idea of exhibiting id quod usu non consumitur for ‘pomp’, id est (by doing) ‘ostentation’. The basic idea of the Author is that Ulpian has specifically designated two terms, ‘pompa vel ostentatio’, to refer to two different (but not opposing) application spheres, in an attempt to synthesis…

Evaluation of the Use of a City Center through the Use of Bluetooth Sensors Network

2019

In order to achieve the objectives of Smart Cities, public administrations need to take measures to regulate mobility, which undoubtedly requires a high level of information and sensorization. Until the implementation of the connected vehicle takes place, it is still necessary to install sensors to obtain information about mobility. Bluetooth sensors are becoming a useful tool due to the low cost of equipment and installation. The use of Bluetooth sensors in cities, with short distances between sensors, makes it necessary to propose new classification algorithms that allow the trips of pedestrians and vehicles to be differentiated. This article presents the study carried out in the city of …

An asynchronous covert channel using spam

2012

AbstractCurrent Internet e-mail facilities are built onto the foundation of standard rules and protocols, which usually allow a considerable amount of “freedom” to their designers. Each of these standards has been defined based on a number of vendor specific implementations, in order to provide common inter-working procedures for cross-vendor communication. Thus, a lot of optional and redundant information is being exchanged during e-mail sessions, which is available to implement versatile covert channel mechanisms.This work exploits this possibility by presenting a simple but effective steganographic scheme that can be used to deploy robust secret communication through spam e-mails. This s…

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Association between DRD2/DRD4 interaction and conduct disorder: a potential developmental pathway to alcohol dependence

2013

1 Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil 2 King’s College London, Institute of Psychiatry, MRC Social Genetic and Developmental Psychiatry Centre, London, United Kingdom, UK 3 Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany 4 Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands 5 Psychology Department, National University of Singapore, Singapore, Singapore 6 Department of Psychiatry, Donders Institute for Brain, Cognition an…

Attention-deficit hyperactivity disorder (ADHD), substance use disorders, and criminality: a difficult problem with complex solutions.

2014

Abstract The association between attention-deficit hyperactivity disorder (ADHD) and criminality has been increasingly recognized as an important societal concern. Studies conducted in different settings have revealed high rates of ADHD among adolescent offenders. The risk for criminal behavior among individuals with ADHD is increased when there is psychiatric comorbidity, particularly conduct disorder and substance use disorder. In the present report, it is aimed to systematically review the literature on the epidemiological, neurobiological, and other risk factors contributing to this association, as well as the key aspects of the assessment, diagnosis, and treatment of ADHD among offende…

Conductes prosocials i responsabilitat social universitària: a la recerca d’un cercle virtuós?

2019

espanolAnte un contexto social con dificultades asociadas a altos indicadores de violencia, se efectua una revision bibliografica de articulos publicados hasta el ano 2017, con las palabras clave conducta prosocial, programas de intervencion y responsabilidad social a fin de reflexionar respecto de la relacion entre el desarrollo de conductas prosociales y la responsabililidad dad social universitaria (RSU). Lo anterior ha permitido plantear la posibilidad de circulos virtuosos que junto con favorecer la prosocialidad en futuros universitarios, propicie que adultos formados en rsu favorezcan contextos de desarrollo prosociales para futuras generaciones. catalaDavant d’un context social amb …