Search results for "PAM"
showing 10 items of 1768 documents
5PSQ-096 Hazard vulnerability analysis to evaluate the risk of drug shortages according to therapeutic class
2020
Background and importance Drug shortages are a critical challenge for the public health system, as highlighted by EAHP’s position paper. They have a negative impact on quality and efficiency of patient care. Aim and objectives The aim of our study was the application of a revised hazard vulnerability analysis (HVA) to assess which therapeutic classes of drugs are at greatest risk of shortages. Material and methods In September 2019, we analysed the drugs present in our hospital therapeutic formulary and checked which ones were included in the Italian Medicines Agency shortages list: 43 drugs were found. For each drug, we assigned a score using a revised HVA which consists of three macro are…
Impact of adolescent methamphetamine use on social cognition: A human-mice reverse translation study.
2021
Background: Methamphetamine dependence is associated with social cognition deficits that may underpin negative social outcomes. However, there are considerable inter-individual differences in social cognition within people with methamphetamine dependence, with age of onset of methamphetamine use being a potential contributing factor. Materials and methods: We conducted two sequential studies examining the link between age of onset of methamphetamine use (adolescence versus young adulthood) and performance in social cognition tests: (1) a human cross-sectional study in 95 participants with methamphetamine dependence varying in age of onset (38 with adolescent onset and 57 with adult onset) a…
Both Short- and Long-Acting D-1/D-2 Dopamine Agonists Induce Less Dyskinesia than l-DOPA in the MPTP-Lesioned Common Marmoset (Callithrix jacchus)
2002
Abstract The current concept of dyskinesia is that pulsatile stimulation of D-1 or D-2 receptors by l -DOPA or short-acting dopamine agonists is more likely to induce dyskinesia compared to long-acting drugs producing more continuous receptor stimulation. We now investigate the ability of two mixed D-1/D-2 agonists, namely pergolide (long-acting) and apomorphine (short-acting), to induce dyskinesia in drug-naive MPTP-lesioned primates, compared to l -DOPA. Adult common marmosets ( Callithrix jacchus ) were lesioned with MPTP (2 mg/kg/day sc for 5 days) and subsequently treated with equieffective antiparkinsonian doses of l -DOPA, apomorphine, or pergolide for 28 days. l -DOPA, apomorphine, …
Eiropas Cilvēktiesību un pamatbrīvību aizsardzības konvencijas 16. protokols: mērķi, saturs, nozīme
2016
Eiropas Cilvēktiesību un pamatbrīvību aizsardzības konvencijas (turpmāk - Konvencija) 16.protokols ir daļa no pasākumiem, kas tiek veikti Konvencijas ilgtermiņa reformu kontekstā. Ar to paplašina Eiropas Cilvēktiesību tiesas (turpmāk – ECT) rekomendējošo jurisdikciju un ievieš jaunu mehānismu Konvencijas cilvēktiesību aizsardzības sistēmā, atbilstoši kuram šī protokola dalībvalstu pēdējo instanču tiesas un tribunāli varēs lūgt ECT sniegt rekomendējošu viedokli. Darbā autors atklāj Konvencijas 16.protokola mērķus, analizē un pēta protokola saturu. Tiek secināts, ka regulējums kaut gan nepilnīgs, ir apmierinošs. Darbā arī tiek izvērtēta protoko…
Mācību ekskursija bioloģijas apguvē pamatskolā
2015
Mācību ekskursija bioloģijas apguvē pamatskolā. Renāte Ozoliņa, darba vadītājs vadošā pētniece, Dr. paed. Rita Birziņa. Bakalaura darbs, 49 lpp., 36 literatūras avoti, 13 pielikumi, 13 attēli un 5 tabulas. Latviešu valodā. Darba mērķis ir izpētīt mācību ekskursijas izmantošanas iespējas bioloģijas mācību priekšmeta apguves pilnveidošanā. Pētījuma laikā, apkopota teorētiskā literatūra par mācību ekskursiju, apzināts Latvijas Dabas muzeja ekskursiju piedāvājums skolām, ar anketu palīdzību noskaidrots skolēnu viedoklis par mācību ekskursijām. Pētījuma ietvaros izveidota un aprobēta mācību ekskursija muzejā „Latvijas putnu daudzveidība”. Noskaidrots, ka mācību ekskursija kā mācību organizācijas…
Changes in the contractility of colon from hypoxanthine-guanine phosphoribosyltransferase (HPRT) knockout mice (Lesch-Nyhan disease)
2009
The sterilization of eco-criticism: from sustainable development to green capitalism
2015
[eng] Development has been a dominant and highly visible trope of the global political and economic life of the world since the 1950s. As such it has been inevitably linked to some of the most important social processes of this era: colonialism, globalization, postcolonialism, global ecological crisis, the rise of environmentalism, and more. The consolidation of the contemporary consumer global society came, hand by hand, with the certainty that it sustained a way of life that as a collateral damage, included a global ecological crisis. From many quarters of the world new voices raised concerns about the costs of globalization and proposed alternatives and solutions: modern eco-criticism wa…
Dos models d'economies perifèriques antagòniques des de la perspectiva de la justícia ambiental: la Ribera d’Ebre i el Priorat
2019
La Ribera d’Ebre i el Priorat són dos exemples paradigmàtics d’economies perifèriques tenint en compte la seva estructura productiva. Tanmateix, en les darreres dècades ambdues comarques plantegen un model de desenvolupament socioeconòmic divergent que es tradueix en un model de justícia ambiental antagònic: mentre a la Ribera d’Ebre s’intensifica el caràcter d’economia dependent en base a un model de producció extractiu al Priorat s’assaja un model de desenvolupament endogen com a model alternatiu d’explotació dels recursos naturals, impulsat per la societat civil i les institucions públiques. Aquesta disjuntiva planteja la necessitat d’afrontar un debat sobre la legislació vigent, que no …
El papel de las cooperativas de crédito en el sostenimiento de la España vaciada a través del capital social
2021
El sistema bancario viene experimentando grandes transformaciones, marcadas por la disminución del número de entidades y la concentración del negocio. Las cooperativas de crédito han logrado mantenerse relativamente aisladas de las turbulencias financieras de la pasada crisis gracias a políticas de inversión prudentes y la clara vocación territorial y de proximidad con el entorno, características que, junto con su carácter cooperativo, se han convertido en las principales fortalezas de este tipo de entidades de crédito. Por otra parte, la creciente desatención del sistema bancario hacia los territorios en retroceso demográfico ha propiciado la exclusión financiera de sus habitantes. En este…
Empreendedorismo, inovação e internacionalização: o papel moderador das instituições
2021
Abstract The favorable effects of innovation and internationalization on the development of the economies of countries have been prominent factors in multiple management studies. The objective of this document is to make a theoretical review of the studies contained in the ScienceDirect (Elsevier) and ResearchGate databases, to offer an integrating framework of those institutional factors in the countries that favor the positive spillover of these two strategic actions carried out by companies: innovation and internationalization. As a result, we observed that an institutional framework characterized by a simplification of bureaucratic administrative procedures to access the financial resou…