Search results for "PAM"
showing 10 items of 1768 documents
Potenciant un turisme cultural atractiu pel patrimoni de Llíria més enllà dels pilars tradicionals d'arqueologia, bandes de música i fires gastronòmi…
2019
[EN] This study of tourism in Llíria/Liriais based on surveys, which gathered statistical data on the visits made to city and the reasons for visiting it, in order to determine the tourist potential of the municipality. The study made it possible to extract relevant information to formulate tourist interests around three attractive cultural elements: the typical interests of historical character, gastronomy through food festivals, and music in the form of local band competitions. This last attractionof the "City of Music"could constitute the key to developing a different local offering, Llíria 2.0. The Internet inclusive of networks and social media have brought a new era for promoting and …
Multixenobiotic resistance efflux activity in Daphnia magna and Lumbriculus variegatus
2014
Multixenobiotic resistance is a phenomenon in which ATP-binding cassette (ABC) family proteins transfer harmful compounds out of cells. Daphnia magna and Lumbriculus variegatus are model species in aquatic ecotoxicology, but the presence and activity of ABC proteins have not been well described in these species. The aim of this work was to study the presence, activity, and inhibition of ABC transport proteins in D. magna and L. variegatus. The presence of abcb1 and abcc transcripts in 8-9-day-old D. magna was investigated by qRT-PCR. The activity of MXR in D. magna and L. variegatus was explored by influx of the fluorescent ABC protein substrates rhodamine B and calcein-AM, with and without…
mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity
2018
Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell metabolism and lymphocyte proliferation. It is inhibited by the tuberous sclerosis complex (TSC), a heterodimer of TSC1 and TSC2. Deletion of either gene results in robust activation of mTORC1. Mature B cells reside in the spleen at two major anatomical locations, the marginal zone (MZ) and follicles. The MZ constitutes the first line of humoral response against blood‐borne pathogens and undergoes atrophy in chronic inflammation. In previous work, we showed that mice deleted for TSC1 in their B cells (TSC1(BKO)) have almost no MZ B cells, whereas follicular B cells are minimally affected. To explore potential underl…
Līvānu stikla fabrikas vēsture no 1970. gada līdz 1995. gadam
2019
Bakalaura darba temats ir “Līvānu stikla fabrikas vēsture no 1970. gada līdz 1995. gadam”. Šī bakalaura darba galvenais mērķis ir apkopot informāciju par Līvānu stikla fabriku dokumentos, publikācijas un mutvārdu vēstures stāstos laika posmā no 1975. gada līdz 1992. gadam un salīdzināt galvenos procesus un notikumus, kas notikuši fabrikas vēsturē. Tā rezultātā noskaidrot Līvānu stikla fabrikas nozīmi. Pētījuma rezultātā tapis bakalaura darbs, kur tika izpētīta un apzināta informācija par Līvānu stikla fabriku, tās vēsturi, galvenajiem attīstības posmiem, sabiedrisko dzīvi un norieta periodu. Pētījumā izmantoti Līvānu novada Centrālās bibliotēkās pieejamie novadpētniecības materiāli. Padziļi…
Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prost…
2020
Background TP53 plays critical roles in sensitivity to chemotherapy, and aging. Collagen is very important in aging. The molecular structure and biochemical properties of collagen changes during aging. The discoidin domain receptor (DDR1) is regulated in part by collagen. Elucidating the links between TP53 and DDR1 in chemosensitivity and aging could improve therapies against cancer and aging. Results Restoration of WT-TP53 activity resulted in increased sensitivity to chemotherapeutic drugs and elevated expression of key components of the Raf/MEK/ERK, PI3K/Akt and DDR1 pathways. DDR1 could modulate the levels of Raf/MEK/ERK and PI3K/Akt pathways as well as sensitize the cells to chemothera…
Modelēšanas kompetence matemātikā pamatskolā un tās vērtēšana
2016
Modelēšanas kompetence matemātikā un tās vērtēšana. Logina, M., zinātniskā vadītāja vad. pētniece, Dr. math. France, I. Maģistra darbs, 47 lappuses, 16 attēli, 8 tabulas, 17 literatūras avoti, 6 pielikumi. Latviešu valodā. Pētījuma mērķis ir izveidot mācību stundu piemērus modelēšanas kompetences apgūšanai pamatskolā un izpētīt to efektivitāti. Izstrādātie piemēri aprobēti Jūrmalas Alternatīvās skolas 6. klasē. Darbā iegūti secinājumi par to, kas ir būtiskākie priekšnoteikumi, lai skolēni sekmīgi apgūtu matemātiskās modelēšanas kompetenci, kā to iespējams mācību procesa laikā vērtēt, lai uzlabotu mācīšanos.
Synthesis and in vitro studies on a potential dopamine prodrug.
2008
Dopamine delivery to the central nervous system (CNS) undergoes the permeability limitations of blood-brain barrier (BBB) which is a selective interface that excludes most water-soluble molecules from entering the brain. Neutral amino acids permeate the BBB by specific transport systems. Conden- sation of dopamine with neutral amino acids could afford potential prodrugs able to interact with the BBB endogenous transporters and easily enter the brain. The synthesis and characterization of the dopamine derivative 2-amino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-phenyl-propionamide (7) is de- scribed. The chemical and enzymatic stability of 7 was evaluated. The molecular weight (300 Da) and Log P …
Synthesis and characterization of biotinylated and photoactivatable neuroleptics. Novel bifunctional probes for dopamine receptors
1992
Abstract We have synthesized and characterized a series of novel derivatives of established antagonists of the neurotransmitter dopamine, i.e. butyrophenones, hexahydrocarbolines and phenothiazenes. All derivatives were biotinylated, some of them carried an additional (photoactivatable) azido group. In the case of butyrophenones, the structural modifications were introduced at the aliphatic keto group and/or the heterocyclic ring system, both modifications resulting in significant decreases in binding affinity to dopamine D 2 and dopamine D 1 receptor subtypes. Biotinylation of hexahydrocarbolines significantly increased their binding affinity to D 1 receptors, with the affinity for D 2 rec…
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metab…
2021
Gut: first published.
Sex Differences in the Neuroadaptations of Reward-related Circuits in Response to Subchronic Variable Stress
2018
Women are twice as likely to be diagnosed with major depressive disorder. However, fewer studies in rodent models of depression have used female animals, leading to a relative lack of understanding of the female brain’s response to stress, especially at a neural circuit level. In this study, we utilized a 6-day subchronic variable stress (SCVS) mouse model and measured novelty suppressed feeding as behavioral criteria to evaluate susceptibility to SCVS in male and female mice. First, we showed that SCVS induced a decrease in latency to eat (susceptible phenotype) in female mice, but not in males (resilient phenotype). After determining behavioral phenotypes, we investigated the firing activ…