Search results for "PANA"

Antipsychotic effects and tolerability of the sigma ligand EMD 57445 (panamesine) and its metabolites in acute schizophrenia: an open clinical trial.

2000

Antipsychotic efficacy and side effects of the selective sigma ligand EMD 57445 (panamesine) were investigated in 12 patients (6 males, 6 females) who met DSM-III-R criteria for schizophrenia. A 4-week open clinical study revealed only modest effects of EMD 57445 and its metabolites on positive and negative symptoms of schizophrenia. Extrapyramidal and other side effects were moderate, although a significant increase in mild dyskinetic movements was found. Five patients, four of whom were females, completed the trial. Dropouts were mainly due to treatment failure. Antipsychotic effects were significantly greater in female than male patients.

Occupancy of striatal D 2 -like dopamine receptors after treatment with the sigma ligand EMD 57445, a putative atypical antipsychotic

1999

Rationale: EMD 57445 (panamesine) is a high affinity sigma ligand with the profile of an atypical antipsychotic in animal studies. It has been reported recently to have antipsychotic activity in schizophrenia. However, its metabolite, EMD 59983, binds also to D2 and D3 dopamine (DA) receptors. Objectives: The aim of this study was to test, using single photon emission computed tomography (SPECT) and [123I]iodobenzamide (IBZM) as the radiotracer, whether EMD 59983 would pass the blood-brain barrier and to what extent it would contribute to the effects of EMD 57445 in schizophrenia. Methods: Two IBZM SPECT-scans were performed in five neuroleptic-free schizophrenic patients (DSM IV), one befo…

Constraints on mantle source and interactions due to He-Ar isotope variations in Marsili seamount and eastern Aeolian Volcanic Arc (Panarea and Strom…

2011

Diastereoselective synthesis of antiquorin and related polyoxygenated atisene-type diterpenes

2007

Abstract A diastereoselective approach to polyoxygenated atisene-type diterpenes starting from (S)-(+)-carvone is described. The key steps used in the preparation of the atisene framework are an intramolecular Diels–Alder reaction, an intramolecular diazoketone cyclopropanation, an endocyclic cyclopropane ring cleavage and the regioselective reduction of an allylic bromide by a low-valent chromium species. The synthesis of natural atisanes antiquorin (1), atis-16-ene-3,14-dione (3), atis-16-ene-2,3,14-trione (8) and 3β-hydroxy-atis-16-ene-2,14-dione (9) following this approach is presented. Also described is the synthesis of 18-hydroxy-atis-16-ene-3,14-dione (5), the structure erroneously a…

Bioactive Alkaloids of Hallucinogenic Mushrooms

2015

Abstract The aim of our chapter is to review recent developments in a group of medicinally important natural products–alkaloids, with reference to the structure–activity studies in respect of certain diseases. Alkaloids covered by our review come from mushrooms called “hallucinogenic.” Hallucinogenic compounds have been chemically identified in mushrooms belonging to various genera, e.g., Agrocybe, Amanita, Conocybe, Galerina, Gymnopilus, Hypholoma, Inocybe, Panaeolus, Psilocybe, Pholiotina, Pluteus, and Weraroa [J.W. Allen, Ethnomycol. J. Sacred Mushroom Stud. 9 (2012) 130–175]. One of the largest classes of alkaloids is indole alkaloids. Indoles are probably the most widely distributed he…

Risque phytosanitaire (ARP) portant sur Fusarium oxysporum f. sp. cubense (agent pathogène responsable de la maladie de Panama) pour les départements…

2018

Risque phytosanitaire (ARP) portant sur [i]Fusarium oxysporum[/i] f. sp.[u] cubense[/u] (agent pathogène responsable de la maladie de Panama) pour les départements d'Outre-mer

An adventive Panaeolus antillarum in Poland (Basidiomycota, Agaricales) with notes on its taxonomy, geographical distribution, and ecology

2014

Abstract Coprophilous fungus, Panaeolus antillarum rarely recorded in Europe, is reported here for the first time from the Augustow Plane, north-eastern Poland. This thermophilic species was found outdoors in August on horse dung mixed with straw. A chemical analysis did not confirm the presence of the psychoactive alkaloids in collected material. A complete description and illustration of the species based on Polish specimens are presented and notes on its taxonomy, ecology, world distribution and comparison with similar taxa — P. semiovatus var. semiovatus, P. semiovatus var. phalaenarum, and others are also provided.

Antibacterial and Antifungal Activities of Acetonic Extract from Paullinia cupana Mart Seeds

2013

The antibacterial and antifungal activities of the acetone extract from Paullinia cupana var. sorbilis Mart. (Sapindaceae) seeds, commonly called guarana, were assessed against selected bacterial and fungal strains. We tested the extract against both standard American Type Culture Collection (ATCC) and clinically isolated (CI) bacterial strains and three fungal strains. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values for bacteria and MIC and minimum fungicidal concentration for fungi were determined. The extract showed an activity against the nine bacterial strains tested, both CI and ATCC strains (MIC comprised between 32 and 128 μm/mL and MBC bet…

Análisis de los Stakeholders (actores) como instrumento potencial en los procesos de participación de las agendas 21 local. El caso de Sonà (Panamà)

2008

Three-dimensional solar radiation effects on the actinic flux field in a biomass-burning plume

2003

[1] Three-dimensional (3-D) solar radiative transfer models describe radiative transfer under inhomogeneous atmospheric conditions more accurately than the commonly used one-dimensional (1-D) radiative transfer models that assume horizontal homogeneity of the atmosphere. Here results of 3-D radiative transfer simulations for a biomass-burning plume are presented and compared with local one-dimensional (l-1-D) simulations, i.e., 1-D simulations in every column of the model domain. The spatial distribution of the aerosol particles was derived from a 3-D atmospheric transport simulation. We studied the impact of 3-D radiative effects on the actinic flux within the plume center. The differences…