Search results for "PAP"
showing 10 items of 3248 documents
Correlation study of GAPDH, Bcl-2, and Bax protein immunoexpression in patients with colorectal adenocarcinoma.
2018
Introduction Colorectal cancer (CRC) is the third and second most commonly diagnosed cancer worldwide in males and females, respectively. Despite prominent progress in diagnosis and treatment, the recurrence rates are still high. A tumour hypoxic environment leads to an increase in glycolytic metabolism. The crucial intermediate component of glycolysis, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), could play a significant role in cancer progression. An increased level of GAPDH has been described in oncogene-induced transformation and anti-apoptotic function. In other studies, GAPDH has been involved in apoptosis induction. Aim We examined colorectal adenocarcinoma samples to assess the…
La Crisis migratoria europea en El País e Izvestia: estudio ético y deontológico
2020
espanolEl objetivo de este estudio es analizar desde la perspectiva etica y deontologica la cobertura informativa de la crisis migratoria europea en las versiones digitales de los diarios El Pais (Espana) e Izvestia (Rusia). El estudio aborda textos informativos, se realiza en perspectiva sincronica, se basa en la revision de los principales documentos de referencia en el ambito a nivel nacional e internacional y combina las aproximaciones cuantitativa y cualitativa al analisis de contenido de la prensa. El analisis revela numerosos casos del incumplimiento de las normas eticas en ambos periodicos con significativas diferencias y similitudes a nivel cualitativo. EnglishThe objective of this…
From Tian'anmen Square to the global world stage: framing China in the German press, 1986–2006
2011
Beginning with the historical background, the study investigates how two leading German newspapers covered the People's Republic of China from 1986 to 2006. These two decades were characterized by political turmoil and increased trade relations between the two economically powerful countries. The content analysis, which focuses on the amount of coverage, topics, and journalistic forms, attempts to describe how China has been framed over the years. The findings show an increasing significance of the economy on which again and again shadows were cast by political conflicts. Six frames can be observed; some are positive (political cooperation) and some are negative (scepticism with regard to p…
Region Community in Communication Theory
2014
The aim of the report is to determine how local and regional newspapers represent local communities and how their communicative integration has been promoted. Mass media, establishing community cognition about its existence, involvement into the community, identification and belonging to the community, represent a perfect model of interaction between community and communication. During the content analysis of the press publications of local newspapers of Latgale region the typological characteristics and classification are emphasized, the role of the press in the development of the region inhabitants is defined, the direction and structure of the editorial board activities, newspapers’ cont…
Start-up with or without inoculum? Analysis of an SMBR pilot plant.
2010
This study analysed a submerged membrane bioreactor (SMBR) start-up with the purpose of determining the best conditions to carry it out. In order to do this, a hollow fibre membrane module was installed in a submerged configuration in a pilot aerobic reactor. The experiment was then divided in two phases, lasting 65 days each. During phase 1, the pilot plant was started-up without inoculum of activated sludge and no sludge, withdrawal was performed. Conversely, in phase 2, the MBR pilot plant was started-up with sludge inoculum and the sludge concentration was kept constant. In both phases, the volumetric loading rate applied to the pilot plant was kept constant. The authors analysed the di…
Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2
2020
Abstract Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure‐activity relationships (SAR) of the noncovalent active‐site directed inhibitor (R)‐5‐amino‐2‐methyl‐N‐(1‐(naphthalen‐1‐yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS‐CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PLpro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS‐CoV‐2 replication in …
Bodily dimensions of reading and writing practices on paper and digitally
2015
The bodily aspects of reading/writing practices are investigated in Finland.The paper is considered more adaptive to varied reading purposes than the screen.Handwriting is described as a more flexible and relaxed practice than typing.Skills determine less than materials and images the practices of reading/writing.Digital interfaces determine the ways we read and write less than suggested. This article investigates the different shapes in which reading and writing practices occur when paper/pen are compared with keyboard/screen. The focus is on the bodily aspects of these practices. Reading and writing are viewed as techniques of the body, which over the years have become increasingly mediat…
PVAmpliconFinder: a workflow for the identification of human papillomaviruses from high-throughput amplicon sequencing
2019
Abstract Background The detection of known human papillomaviruses (PVs) from targeted wet-lab approaches has traditionally used PCR-based methods coupled with Sanger sequencing. With the introduction of next-generation sequencing (NGS), these approaches can be revisited to integrate the sequencing power of NGS. Although computational tools have been developed for metagenomic approaches to search for known or novel viruses in NGS data, no appropriate tool is available for the classification and identification of novel viral sequences from data produced by amplicon-based methods. Results We have developed PVAmpliconFinder, a data analysis workflow designed to rapidly identify and classify kno…
Editorial: Mining Scientific Papers: NLP-enhanced Bibliometrics
2019
International audience
Identification of Reading Difficulties by a Digital Game-Based Assessment Technology
2020
Computerized game-based assessment (GBA) system for screening reading difficulties may provide substantial time and cost benefits over traditional paper-and-pencil assessment while providing means also to individually adapt learning content in educational games. To study the reliability and validity of a GBA system to identify struggling readers performing below a standard deviation from mean in paper-and-pencil test either in raw scores and grade-normative scores, a large-scale study with first to fourth grade students ( N = 723) was conducted, where GBA was administrated as a group test by tablet devices. Overall, the results indicated that the GBA can be successfully used to identify st…