Search results for "PAPER"
showing 10 items of 2166 documents
Dicyclopentaannelated Hexa-peri-hexabenzocoronenes with a Singlet Biradical Ground State
2021
Abstract Synthesis of two dicyclopentaannelated hexa‐peri‐hexabenzocoronene (PHBC) regioisomers was carried out, using nonplanar oligoaryl precursors with fluorenyl groups: mPHBC 8 with two pentagons in the “meta”‐configuration was obtained as a stable molecule, while its structural isomer with the “para”‐configuration, pPHBC 16, could be generated and characterized only in situ due to its high chemical reactivity. Both PHBCs exhibit low energy gaps, as reflected by UV‐vis‐NIR absorption and electrochemical measurements. They also show open‐shell singlet ground states according to electron paramagnetic resonance (EPR) measurements and density functional theory (DFT) calculations. The use of…
Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configurati…
2020
mRNA homoeostasis is favoured by crosstalk between transcription and degradation machineries. Both the Ccr4-Not and the Xrn1-decaysome complexes have been described to influence transcription. While Ccr4-Not has been shown to directly stimulate transcription elongation, the information available on how Xrn1 influences transcription is scarce and contradictory. In this study we have addressed this issue by mapping RNA polymerase II (RNA pol II) at high resolution, using CRAC and BioGRO-seq techniques in Saccharomyces cerevisiae. We found significant effects of Xrn1 perturbation on RNA pol II profiles across the genome. RNA pol II profiles at 5ʹ exhibited significant alterations that were com…
Mutant HRAS as novel target for MEK and mTOR inhibitors.
2015
HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung, bladder and esophageal cancer. HRAS mutation sensitized toward growth inhibition by the MEK inhibitors AZD6244, MEK162 and PD0325901. Further, we found that MEK inhibitors induce apoptosis in mutant HRAS cell lines but not in cell lines lacking RAS mutations. In addition, knockdown of HRAS by siRNA blocked cell growth in mutant HRAS cell lines. Inhibition of the PI3K pathway alone or in combination with MEK inhibitors did not alter signaling nor had an imp…
On stochastic modelling and reliability of systems with moving cracked material
2015
In many industrial processes, such as printing paper, a material travels through a series of rollers unsupported and under longitudinal tension. The value of the tension has an important role in the system behaviour, such as fracture and me- chanical stability. This thesis develops stochastic models for a system in which an elastic, isotropic cracked material travels through a series of spans and studies the probabilities of fracture and instability of the material. The models focus on describing tension variations and initial cracks in the material. Time-dependent tension fluctuations are modelled by the stationary Ornstein-Uhlenbeck process, and the occurrence and lengths of the cracks are…
The stress-strain state and stabilization of viscoelastoplastic, imperfect moving web continuum
2014
Increasing the drying efficiency of cylinder drying
2011
This PhD Thesis concentrates on paper drying: first on the drying rate in a cylinder covered with fabric, enhanced using hot air impingement through the fabric, and its potential effects on paper quality, and second, on the heat transfer rate from hot steam to paper through the cylinder shell. Cylinder drying is a drying method where a heated surface in contact with paper causes water removal from the latter by evaporation. Impingement through the fabric of hot air has been suggested to cause increase in the water removal and drying of paper. Increase in the drying rate by impingement of hot air was confirmed by laboratory tests and by simulations. In laboratory tests the increase in the dr…
On modelling and stability of axially moving viscoelastic materials
2013
Analysis of stability of axially moving orthotropic membranes and plates with a linear non-homogeneous tension profile
2011
Filigranes medievals de l'Arxiu municipal de Sueca (1399-1500).
1984
Recull de les filigranes o marques d’aigua del paper emprat en la documentació municipal des del registre més antic de 1399 fins l’any 1500.