Search results for "PAPER"

Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2

2020

Abstract Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure‐activity relationships (SAR) of the noncovalent active‐site directed inhibitor (R)‐5‐amino‐2‐methyl‐N‐(1‐(naphthalen‐1‐yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS‐CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PLpro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS‐CoV‐2 replication in …

Bodily dimensions of reading and writing practices on paper and digitally

2015

The bodily aspects of reading/writing practices are investigated in Finland.The paper is considered more adaptive to varied reading purposes than the screen.Handwriting is described as a more flexible and relaxed practice than typing.Skills determine less than materials and images the practices of reading/writing.Digital interfaces determine the ways we read and write less than suggested. This article investigates the different shapes in which reading and writing practices occur when paper/pen are compared with keyboard/screen. The focus is on the bodily aspects of these practices. Reading and writing are viewed as techniques of the body, which over the years have become increasingly mediat…

Editorial: Mining Scientific Papers: NLP-enhanced Bibliometrics

2019

International audience

Identification of Reading Difficulties by a Digital Game-Based Assessment Technology

2020

Computerized game-based assessment (GBA) system for screening reading difficulties may provide substantial time and cost benefits over traditional paper-and-pencil assessment while providing means also to individually adapt learning content in educational games. To study the reliability and validity of a GBA system to identify struggling readers performing below a standard deviation from mean in paper-and-pencil test either in raw scores and grade-normative scores, a large-scale study with first to fourth grade students ( N = 723) was conducted, where GBA was administrated as a group test by tablet devices. Overall, the results indicated that the GBA can be successfully used to identify st…

Using eye-tracking to assess sourcing during multiple document reading: A critical analysis

2018

During the last 15 years, there have been some efforts to extend the use of eye - tracking to researching reading in complex contexts, such as the reading of multiple documents. The research community involved in this extension has been interested in higher - order comprehensio n processes occurring in complex reading contexts, such as sourcing, defined as the processes of attending to, representing, evaluating, and using available or accessible information about the sources of textual content. In this article, we argue that exte nding eye - tracking research to investigate more complex reading contexts has been made without critically reflecting on its validity in those contexts . Specific…

Conceptual Framework: Dibattito e proposte

2014

Staging Life — Interpretation of Life in Kierkegaard’s

2000

“Whether custom and social life in England is of the stuff of primieval rock or whether it consists in seams and glacial debris will become more and more apparent in the course of a few years. At times, the wanderer is overcome by a sensation comparable to that felt when climbing Rosstrappe [an elevation near Magdeburg in present-day Saxony-Anhalt], where the eye ascends over millions of seemingly loose chunks of slate”.1 These lines, published on the 21st of May, 1870 in the German newspaper Neue Preussische Zeitung by the observer Theodore Fontane, might seem, at first sight, to not be a matter of special interest to readers a century apart (unless we are interested in the literary styles…

A conformationally adaptive macrocycle : conformational complexity and host–guest chemistry of zorb[4]arene

2018

Large amplitude conformational change is one of the features of biomolecular recognition and is also the basis for allosteric effects and signal transduction in functional biological systems. However, synthetic receptors with controllable conformational changes are rare. In this article, we present a thorough study on the host–guest chemistry of a conformationally adaptive macrocycle, namely per-O-ethoxyzorb[4]arene (ZB4). Similar to per-O-ethoxyoxatub[4]arene, ZB4 is capable of accommodating a wide range of organic cations. However, ZB4 does not show large amplitude conformational responses to the electronic substituents on the guests. Instead of a linear free-energy relationship, ZB4 foll…

Reactivity of Nickel(II) Porphyrins in oCVD Processes—Polymerisation, Intramolecular Cyclisation and Chlorination

2019

Abstract Oxidative chemical vapour deposition of (5,15‐diphenylporphyrinato)nickel(II) (NiDPP) with iron(III) chloride as oxidant yielded a conjugated poly(metalloporphyrin) as a highly coloured thin film, which is potentially useful for optoelectronic applications. This study clarified the reactive sites of the porphyrin monomer NiDPP by HRMS, UV/Vis/NIR spectroscopy, cyclic voltammetry and EPR spectroscopy in combination with quantum chemical calculations. Unsubstituted meso positions are essential for successful polymerisation, as demonstrated by varying the porphyrin meso substituent pattern from di‐ to tri‐ and tetraphenyl substitution. DFT calculations support the proposed radical oxi…

Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper

2018

Current evidence shows that cholesterol management either reduces the likelihood of cardiovascular disease (CVD) or slows down its progression. Hence, it is important that all health professionals make appropriate use of all the available intervention strategies to control risk factors: from dietary improvement and positive lifestyle changes to the use of functional foods, food supplements, and drugs. This review examines the effect of the most frequently occurring cholesterol-lowering substances in functional foods or in supplements across Europe, namely plant sterols and stanols, monacolin K found in red yeast rice, berberine and beta-glucans. We conclude that currently available suppleme…