Search results for "PARKIN"

showing 10 items of 468 documents

Prevalence of fatigue in Parkinson disease and its clinical correlates

2014

Objective: To assess in a noninterventional setting the prevalence and severity of fatigue in patients with Parkinson disease (PD). Methods: This was a cross-sectional study conducted in Italian patients with PD. Objectives included the evaluation of the current prevalence and severity of fatigue in patients with PD measured using the 16-item Parkinson Fatigue Scale (PFS-16), distressing fatigue (defined as a PFS-16 mean score $3.3), and assessment of its clinical correlates. Results: A total of 402 patients were enrolled and 394 patients completed the PFS-16 questionnaire with a PFS-16 mean (6SD) score of 2.87 6 0.99. Of these, 136 patients (33.8%) reported distressing fatigue (PFS-16 mean…

MaleTime FactorsDiseaseDSM-IV 5 Diagnostic and Statistical Manual of Mental Disorders 4th edition; ICD-10 5 International Classification of Diseases 10th revision; MAO-B 5 monoamine oxidase B; MS 5 multiple sclerosis; PD 5 Parkinson disease; PDQ-39 5 39-item Parkinson’s Disease Questionnaire; PDSS 5 Parkinson’s Disease Sleep Scale; PFS-16 5 16-item Parkinson Fatigue Scale; UPDRS 5 Unified Parkinson’s Disease Rating ScaleSeverity of Illness IndexQuality of life80 and overPrevalencePDSS 5 Parkinson’s Disease Sleep ScaleAge FactorDepression (differential diagnoses)FatigueAged 80 and overDepressionmusculoskeletal neural and ocular physiologyAge FactorsParkinson DiseasePDQ-39 5 39-item Parkinson’s Disease QuestionnaireMiddle AgedItalyPFS-16 5 16-item Parkinson Fatigue ScaleFemaleSettore MED/26 - NeurologiaMS 5 multiple sclerosiPsychologyHumanAdultSleep Wake Disordersmedicine.medical_specialtyPD 5 Parkinson diseasemacromolecular substancesArts and Humanities (miscellaneous)Internal medicinemedicineDistressingHumansIn patientAgedCross-Sectional StudieMAO-B 5 monoamine oxidase BUPDRS 5 Unified Parkinson’s Disease Rating Scalenervous system diseasesAdult; Age Factors; Aged; Aged 80 and over; Cross-Sectional Studies; Depression; Fatigue; Female; Humans; Italy; Male; Middle Aged; Parkinson Disease; Prevalence; Severity of Illness Index; Sleep Wake Disorders; Time Factors; Neurology (clinical); Arts and Humanities (miscellaneous)Cross-Sectional Studiesnervous systemICD-10 5 International Classification of Diseases 10th revisionPhysical therapyNeurology (clinical)DSM-IV 5 Diagnostic and Statistical Manual of Mental Disorders 4th editionSleep Disorder
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Autobiographical memory in Parkinson's disease: A retrieval deficit

2012

This study examined the effects of providing cues to facilitate autobiographical memory retrieval in Parkinson's disease. Previous findings have shown that individuals with Parkinson's disease retrieve fewer specific autobiographical memories than older adult controls. These findings are clinically significant since the quality of autobiographical memory is linked to identity and sense of self. In the current study, 16 older adults with Parkinson's disease without dementia and 16 matched older adult controls were given 3 min in which to recall autobiographical memories associated with five different time periods and to give each memory a short title. Participants were later asked to retriev…

MaleTime FactorsParkinson's diseaseRecallAutobiographical memoryMemory EpisodicCognitive NeuroscienceNeuropsychologyParkinson Diseasemedicine.diseaseBehavioral NeuroscienceNeuropsychology and Physiological PsychologyFree recallCase-Control StudiesMental RecallmedicineHumansDementiaFemaleChildhood memoryCuesPsychologyEpisodic memoryAgedCognitive psychologyJournal of Neuropsychology
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Impaired reproduction of second but not millisecond time intervals in Parkinson's disease

2008

The basal ganglia have been associated with temporal processing in ranges of milliseconds and seconds. However, results from PD patient studies are elusive. Time perception in these patients has been tested with different approaches including repetitive movement tasks (i.e. finger tapping) and cognitive tasks (i.e. time reproduction), and both abnormal and normal performances have been reported for different time intervals. Furthermore, when PD patients were required to learn two target durations in the same session when they were off medication, they overestimated the short duration and underestimated the long duration in the seconds range. This pattern of temporal accuracy was described a…

MaleTime perception; Parkinson's disease; Basal ganglia; Dopamine; MemoryParkinson's diseaseDopamineNeuropsychological TestsAudiologyBehavioral neuroscienceAntiparkinson AgentsBehavioral NeuroscienceCognitionAttentionBRAINTomographyDepression; Humans; Tomography X-Ray Computed; Time Perception; Aged; Antiparkinson Agents; Memory Disorders; Cognition; Psychiatric Status Rating Scales; Parkinson Disease; Psychomotor Performance; Middle Aged; Neuropsychological Tests; Attention; Female; Male; Reaction TimeMillisecondDepressionParkinson DiseaseCognitionPsychiatric Status Rating ScaleMiddle AgedTime perceptionTIMEX-Ray ComputedNeuropsychology and Physiological PsychologyAntiparkinson AgentBasal gangliaNeuropsychological TestFemaleSettore MED/26 - NeurologiaPsychologyHumanMemory Disordermedicine.medical_specialtyElementary cognitive taskCognitive NeuroscienceExperimental and Cognitive PsychologyCognitive neuroscienceNOMemoryReaction TimemedicineHumansAgedPsychiatric Status Rating ScalesMemory DisordersSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaMemoriaTime PerceptionFinger tappingTomography X-Ray ComputedPARKINSONNeurosciencePsychomotor PerformanceNeuropsychologia
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Acute inactivation of the medial forebrain bundle imposes oscillations in the SNr: a challenge for the 6-OHDA model?

2010

It has been recently shown that the substantia nigra pars reticulata (SNr) of 6-hydroxydopamine (6-OHDA)-lesioned rats, under urethane anaesthesia, manifests a prominent low frequency oscillation (LFO) of around 1Hz, synchronized with cortical slow wave activity (SWA). Nevertheless, it is poorly understood whether these electrophysiological alterations are correlated only with severe dopamine depletion or may also play a relevant pathogenetic role in the early stages of the dopamine denervation. Hence, here we recorded SNr single units and electrocorticogram (ECoG) in two models of dopamine denervation: (i) acute dopamine denervated rats, obtained by injection of tetrodotoxin (TTX), (ii) ch…

MaleTyrosine 3-Monooxygenasebasal ganglia oscillationsDopamineParkinson's diseaseWistarAction PotentialsParkinson's disease; Low frequency oscillation basal ganglia oscillations; Medial forebrain bundle; Tetrodotoxin; ElectrocorticogramTetrodotoxinSettore BIO/09 - FisiologiaParkinson's disease; low frequency oscillation; basal ganglia oscillations; medial forebrain bundle; Tetrodotoxin; electrocorticogramStatistics NonparametricAnimals; Analysis of Variance; Action Potentials; Electrophysiology; Tyrosine 3-Monooxygenase; Cerebral Cortex; Rats; Biological Clocks; Dopamine; Neurons; Rats Wistar; Substantia Nigra; Immunohistochemistry; Medial Forebrain Bundle; Statistics Nonparametric; MaleMedial forebrain bundlechemistry.chemical_compoundDevelopmental NeuroscienceBiological ClocksDopamineBasal gangliamedicineAnimalsNonparametricRats WistarMedial forebrain bundleElectrocorticographyCerebral CortexNeuronsDenervationAnalysis of Variancemedicine.diagnostic_testChemistryStatisticsLow frequency oscillation basal ganglia oscillationElectrocorticogramImmunohistochemistryRatsCortex (botany)ElectrophysiologySubstantia NigraElectrophysiologynervous systemNeurologylow frequency oscillationTetrodotoxinSettore MED/26 - NeurologiaNeurosciencemedicine.drug
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Neurofunctional correlates of attention rehabilitation in Parkinson's disease: an explorative study

2014

The effectiveness of cognitive rehabilitation (CR) in Parkinson’s disease (PD) is in its relative infancy, and nowadays there is insufficient information to support evidence-based clinical protocols. This study is aimed at testing a validated therapeutic strategy characterized by intensive computer-based attention-training program tailored to attention deficits. We further investigated the presence of synaptic plasticity by means of functional magnetic resonance imaging (fMRI). Using a randomized controlled study, we enrolled eight PD patients who underwent a CR program (Experimental group) and seven clinically/demographically-matched PD patients who underwent a placebo intervention (Contro…

Malemedicine.medical_specialtyBrain activity and meditationPrefrontal CortexDermatologyNeuropsychological TestsStatistical parametric mappingPhysical medicine and rehabilitationParietal LobemedicineHumansAttentionSingle-Blind MethodEffects of sleep deprivation on cognitive performanceCognitive rehabilitation therapyPrincipal Component AnalysisNeuronal PlasticityResting state fMRImedicine.diagnostic_testCognitionParkinson DiseaseGeneral MedicineMiddle AgedMagnetic Resonance ImagingDorsolateral prefrontal cortexPsychiatry and Mental healthParkinson disease rehabilitationmedicine.anatomical_structureMemory Short-TermPhenotypeSpace PerceptionTherapy Computer-AssistedVisual PerceptionFemaleSettore MED/26 - NeurologiaNeurology (clinical)Nerve NetFunctional magnetic resonance imagingPsychologyCognition DisordersNeurosciencePsychomotor Performance
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Is there still a role for lesioning in functional neurosurgery? Preliminary Italian (and world-first) experience with a trans-cranial MRI-guided focu…

2015

Malemedicine.medical_specialtyDeep Brain StimulationEssential TremorFunctional neurosurgeryNeurosurgical Procedures030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicinemedicineHumansUltrasonographybusiness.industryBrainParkinson DiseaseMiddle AgedFocused ultrasound surgeryMagnetic Resonance ImagingItalySurgery Computer-AssistedSurgeryNeurology (clinical)RadiologyTomography X-Ray Computedbusiness030217 neurology & neurosurgeryMri guidedJournal of Neurosurgical Sciences
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Increased neuropeptide Y mRNA expression in striatum in Parkinson's disease.

2003

High levels of neuropeptide Y (NPY) are found in basal ganglia where it is co-localised with somatostatin (SOM) and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH/d) in a population of striatal GABA containing interneurones. Although alterations occur in the levels of various neuropeptides in basal ganglia in Parkinson’s disease (PD), it is not known whether NPY is affected. Using in situ hybridisation immunohistochemistry, we have examined the distribution of NPY mRNA in the caudate nucleus, putamen and nucleus accumbens of normal individuals and patients with PD. NPY mRNA was weakly expressed in the caudate nucleus, putamen and nucleus accumbens in normal individuals with a…

Malemedicine.medical_specialtyIn situ hybridisationPopulationCaudate nucleusNeuropeptideStriatumBiologyNucleus accumbensNucleus AccumbensStriatumCellular and Molecular NeuroscienceNeuropeptide Y (NPY)InterneuronsInternal medicinemental disordersBasal gangliamedicineHumansNeuropeptide YRNA MessengereducationMolecular BiologyAgededucation.field_of_studyPutamenPutamenParkinson DiseaseMiddle AgedNeuropeptide Y receptorhumanitiesCorpus StriatumEndocrinologynervous systemGene Expression RegulationParkinson’s diseaseSettore BIO/14 - FarmacologiaFemaleCaudate NucleusBrain research. Molecular brain research
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Is Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound a Repeatable Treatment Option? Case Report of a Retreated Patient With Tremor Co…

2019

Introduction In recent years, transcranial Magnetic Resonance Imaging-guided Focused Ultrasound (tcMRgFUS) treatments for functional neurological disorders are giving a new thrust to the field of therapeutic brain lesioning. Objective To present the case of a patient affected by tremor combined with Parkinsonism who underwent a second tcMRgFUS thalamotomy because of relapsing tremor after a few months from the first tcMRgFUS treatment. Methods A 72-yr-old, right-handed man, came to our observation because of a disabling tremor affecting his upper limbs, refusing any invasive surgical procedure and already treated by tcMRgFUS left Vim thalamotomy. However, clinical benefit had brief duration…

Malemedicine.medical_specialtyInterventional magnetic resonance imagingmedicine.medical_treatmentEssential TremorFocused ultrasoundParkinsonian DisordersTremorMedicineHumansAgedmedicine.diagnostic_testbusiness.industryPatient affectedThalamotomySettore MED/27 - NeurochirurgiaParkinsonismSettore FIS/01 - Fisica SperimentaleTreatment optionsSettore MED/37 - NeuroradiologiaMagnetic resonance imagingmedicine.diseaseMagnetic Resonance ImagingTreatment OutcomeStereotaxic techniqueSurgerySettore MED/26 - NeurologiaNeurology (clinical)RadiologyHigh-intensity focused ultrasound ablation Minimally invasive surgical procedures Stereo- taxic techniques Tremor Parkinsonian disorders Interventional magnetic resonance imaging Intraoperative monitoringbusinessSettore MED/36 - Diagnostica Per Immagini E Radioterapia
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In patient’s with Parkinson disease, autonomic symptoms are frequent and associated with other non-motor symptoms

2015

Background: Autonomic symptoms and sleep disorders are common non-motor symptoms of Parkinson disease (PD), which are correlated with poor quality of life for patients. Purpose: To assess the frequency of autonomic symptoms in a consecutive series of PD patients and to correlate them with other motor and non-motor symptoms. Methods: All consecutive non-demented PD patients who underwent an extensive evaluation including Hoehn and Yahr staging, Unified Parkinson’s Disease Rating Scale, Beck’s Depression Inventory, Neuropsychiatric Inventory, PDQ-39 Scale, the Parkinson’s diseases Sleep Scale, the Epworth Sleepiness Scale and SCOPA-AUT scale were enrolled. Comorbidity has been also considered…

Malemedicine.medical_specialtyLevodopaNeurologyParkinson's diseaseDiseaseAutonomic symptomNon-motor symptomRating scaleInternal medicinemedicineHumansDepression (differential diagnoses)AgedEndocrine and Autonomic Systemsbusiness.industryEpworth Sleepiness ScaleParkinson DiseaseSleep disordersMiddle Agedmedicine.diseaseComorbidityCross-Sectional StudiesAutonomic Nervous System DiseasesParkinson’s diseaseFemaleSettore MED/26 - NeurologiaNeurology (clinical)businessmedicine.drug
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Chronic l-DOPA treatment increases striatal cannabinoid CB1 receptor mRNA expression in 6-hydroxydopamine-lesioned rats

2000

Abstract The effect of a unilateral 6-hydroxydopamine (6-OHDA) lesion of the left medial forebrain bundle and 3 weeks treatment with l -DOPA of normal and 6-OHDA lesioned rats on CB1r mRNA expression was investigated by in situ hybridization. A 6-OHDA lesion of nigrostriatal pathway alone, confirmed by the loss of nigral tyrosine hydroxylase mRNA, did not alter CB1r mRNA levels in the dopamine depleted striatum. Similarly, chronic l -DOPA treatment of normal rats had no effect on striatal CB1r mRNA expression. In contrast, chronic l -DOPA treatment of 6-OHDA-lesioned rats significantly increased CB1r mRNA expression in the denervated striatum. These results suggest that the CB1r activity ma…

Malemedicine.medical_specialtyLevodopaanimal structuresTyrosine 3-MonooxygenaseReceptors DrugDopamine Agents-DOPANigrostriatal pathwayStriatumBiologySubthalamic nucleusStriatumLevodopaLesionAdrenergic AgentsDopamineInternal medicinemedicineAnimalsRNA MessengerRats WistarOxidopamineReceptors CannabinoidMedial forebrain bundleHydroxydopamineTyrosine hydroxylaseGeneral NeuroscienceMedial Forebrain BundleParkinson DiseaseCorpus StriatumRatsmedicine.anatomical_structureEndocrinologynervous systemSettore BIO/14 - Farmacologiamedicine.symptomCannabinoid CB1 receptor mRNA6-Hydroxydopaminemedicine.drugNeuroscience Letters
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