Search results for "PARKINSON DISEASE"

Planning and executing sequential motor acts in Parkinson Disease

1997

Many experimental evidences highlighted that Parkinson Disease (PD) patients are particularly impaired in performing a sequence of movements. In the present experiment we focused to study how PD patients plan and execute an action constituted by the sequence of reaching-grasping an object (first motor act) and placing it on a second target (second motor act). We wished to determine whether properties of the target of the second motor act influenced the kinematics of first motor act. The results showed that PD patients modified, as the controls, the initial ballistic phase of reaching according to variation of second target position (object extrinsic properties). In particular, peak accelera…

CLINICAL EFFECTS OF DIFFERENT MONTAGES OF TRANSCRANIAL DIRECT CURRENT STIMULATION IN PATIENTS WITH PARKINSON’DISEASE

2014

Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining

2012

Purpose: The aim of this study was to demonstrate that modern data mining tools can be used as one step in reducing the labor necessary to produce and maintain systematic reviews. Methods: We used four continuously updated, manually curated resources that summarize MEDLINE-indexed articles in entire fields using systematic review methods (PDGene, AlzGene, and SzGene for genetic determinants of Parkinson disease, Alzheimer disease, and schizophrenia, respectively; and the Tufts Cost-Effectiveness Analysis (CEA) Registry for cost-effectiveness analyses). In each data set, we trained a classification model on citations screened up until 2009. We then evaluated the ability of the model to class…