Search results for "PARP"
showing 10 items of 39 documents
530MO Clinical benefit in biomarker-positive patients (pts) with locally advanced or metastatic solid tumours treated with the PARP1/2 inhibitor pami…
2020
The Activity of the Nucleosome Remodeling ATPase ISWI is Regulated by poly-ADP-ribosylation
2008
The Nucleosome Remodeling ATPase ISWI is Regulated by poly-ADP-ribosylation
2008
Regulation of Chromatin Remodeling through poly-ADP-ribosylation
2008
The Poly-ADP-Ribose Polymerase PARP Modulates the Activity of the Nucleosome Remodeling ATPase ISWI
2008
Neoadjuvant chemotherapy in advanced-stage ovarian cancer – state of the art
2022
: Ovarian cancer represents the fifth cause of cancer death among women, carrying one of the worst prognoses among gynaecological malignancies. The need to achieve no residual disease after surgery in order to optimize prognosis of advanced-stage ovarian cancer introduced the idea of neoadjuvant chemotherapy. The present review aims to summarize current state-of-the-art evidence regarding the efficacy and safety of neoadjuvant chemotherapy as well as novel insights regarding the usage of modern therapeutic regimens in the context of neoadjuvant chemotherapy. The last decade has been characterized by the breakthrough scientific evidence that neoadjuvant chemotherapy followed by interval debu…
In Human Retinoblastoma Y-79 Cells 3-aminobenzamide induces Differentiation
2006
Differentiative pathway activated by 3-aminobenzamide in human osteosarcoma MG-63 cells involves FAK and PAK activities.
2006
MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate
2019
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethyl-benzofuran-2-carboxylic acid ethyl ester (designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1…
Los caballos en la Cova del Parpalló (Gandía, Valencia)
2005
Se estudian 165 plaquetas grabadas de la Cova del Parpalló, de las que 115 contienen una o varias representaciones de caballos que siguen las mismas grandes tendencias sugeridas por Villaverde. Es posible, con todo, señalar la existencia de dos subtendencias: por un lado un creciente grosor de los trazos, y por otro la consecución del volumen a través de trazos múltiples y repetidos. La tendencia a desarrollar el volumen está en correlación con el alargamiento del cuello y la representación dinámica del pecho, mediante una línea oblicua proyectada hacia adelante. Nuestra intención es, además, poner de manifiesto las concomitancias que se registran en el Solutro-gravetiense entre los cambios…