Search results for "PARTICLES"
showing 10 items of 8085 documents
Wind-luminosity evolution in NLS1 AGN 1H 0707−495
2021
Ultra-fast outflows (UFOs) have been detected in the high-quality X-ray spectra of a number of active galactic nuclei (AGN) with fairly high accretion rates and are thought to significantly contribute to the AGN feedback. After a decade of dedicated study, their launching mechanisms and structure are still not well understood, but variability techniques may provide useful constraints. In this work, therefore, we perform a flux-resolved X-ray spectroscopy on a highly accreting and variable NLS1 AGN, 1H 0707-495, using all archival XMM-Newton observations to study the structure of the UFO. We find that the wind spectral lines weaken at higher luminosities, most likely due to an increasing ion…
The history of chemical enrichment in the intracluster medium from cosmological simulations
2017
The distribution of metals in the intracluster medium (ICM) of galaxy clusters provides valuable information on their formation and evolution, on the connection with the cosmic star formation and on the effects of different gas processes. By analyzing a sample of simulated galaxy clusters, we study the chemical enrichment of the ICM, its evolution, and its relation with the physical processes included in the simulation and with the thermal properties of the core. These simulations, consisting of re-simulations of 29 Lagrangian regions performed with an upgraded version of the SPH GADGET-3 code, have been run including two different sets of baryonic physics: one accounts for radiative coolin…
Coupling hydrodynamics and radiation calculations for star-jet interactions in active galactic nuclei
2016
Context. Stars and their winds can contribute to the non-thermal emission in extragalactic jets. Because of the complexity of jet-star interactions, the properties of the resulting emission are closely linked to those of the emitting flows. Aims. We simulate the interaction between a stellar wind and a relativistic extragalactic jet and use the hydrodynamic results to compute the non-thermal emission under different conditions. Methods. We performed relativistic axisymmetric hydrodynamical simulations of a relativistic jet interacting with a supersonic, non-relativistic stellar wind. We computed the corresponding streamlines out of the simulation results and calculated the injection, evolut…
Jet-torus connection in radio galaxies
2017
High-resolution Very-Long-Baseline Interferometry observations of active galactic nuclei have revealed asymmetric structures in the jets of radio galaxies. These asymmetric structures may be due to internal asymmetries in the jet, could be induced by the different conditions in the surrounding ambient medium including the obscuring torus, or a combination of the two. In this paper we investigate the influence of the ambient medium (including the obscuring torus) on the observed properties of jets from radio galaxies. We performed special-relativistic hydrodynamic (RHD) simulations of over-pressured and pressure-matched jets using the special-relativistic hydrodynamics code \texttt{Ratpenat}…
Correlation of the highest-energy cosmic rays with nearby extragalactic objects.
2007
Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above ~ 6x10^{19} electron volts and the positions of active galactic nuclei (AGN) lying within ~ 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar…
Long-term monitoring of mrk 501 for its very high energy γ emission and a flare in 2011 october
2012
"As one of the brightest active blazars in both X-ray and very high energy γ -ray bands, Mrk 501, is very useful for" "physics associated with jets from active galactic nuclei. The ARGO-YBJ experiment has monitored Mrk 501 for γ - rays above 0.3 TeV since 2007 November. The largest flare since 2005 was observed from 2011 October and lasted until about 2012 April. In this paper, a detailed analysis of this event is reported. During the brightest γ -ray flaring episodes from 2011 October 17 to November 22, an excess of the event rate over 6σ is detected by ARGO-YBJ in the direction of Mrk 501, corresponding to an increase of the γ -ray flux above 1 TeV by a factor of 6.6 ± 2.2 from its steady…
Dissipative Processes and Their Role in the Evolution of Radio Galaxies
2019
Particle acceleration in relativistic jets to very high energies occurs at the expense of the dissipation of magnetic or kinetic energy. Therefore, understanding the processes that can trigger this dissipation is key to the characterization of the energy budgets and particle acceleration mechanisms at action in active galaxies. Instabilities and entrainment are two obvious candidates to trigger dissipation. On the one hand, supersonic, relativistic flows threaded by helical fields, as expected from the standard formation models of jets in supermassive black-holes, are unstable to a series of magnetohydrodynamical instabilities, such as the Kelvin-Helmholtz, current-driven, or possibly the p…
Targeted-lung delivery of dexamethasone using gated mesoporous silica nanoparticles. A new therapeutic approach for acute lung injury treatment
2021
Acute lung injury (ALI) is a critical inflammatory syndrome, characterized by increased diffuse inflammation and severe lung damage, which represents a clinical concern due to the high morbidity and mortality in critical patients. In last years, there has been a need to develop more effective treatments for ALI, and targeted drug delivery to inflamed lungs has become an attractive research field. Here, we present a nanodevice based on mesoporous silica nanoparticles loaded with dexamethasone (a glucocorticoid extensively used for ALI treatment) and capped with a peptide that targets the TNFR1 receptor expressed in pro-inflammatory macrophages (TNFR-Dex-MSNs) and avoids cargo leakage. TNFR-D…
Therapeutic Vaccination of Hematopoietic Cell Transplantation Recipients Improves Protective CD8 T-Cell Immunotherapy of Cytomegalovirus Infection
2021
Reactivation of latent cytomegalovirus (CMV) endangers the therapeutic success of hematopoietic cell transplantation (HCT) in tumor patients due to cytopathogenic virus spread that leads to organ manifestations of CMV disease, to interstitial pneumonia in particular. In cases of virus variants that are refractory to standard antiviral pharmacotherapy, immunotherapy by adoptive cell transfer (ACT) of virus-specific CD8+ T cells is the last resort to bridge the “protection gap” between hematoablative conditioning for HCT and endogenous reconstitution of antiviral immunity. We have used the well-established mouse model of CD8+ T-cell immunotherapy by ACT in a setting of experimental HCT and mu…
Circulating microparticles as disease-specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis.
2012
Background & Aims Microparticles released into the bloodstream upon activation or apoptosis of CD4+ and CD8+ T cells correlate with inflammation as determined by histologic analysis in patients with chronic hepatitis C (CHC). Patients with nonalcoholic fatty liver (NAFL) or nonalcoholic steatohepatitis (NASH) can be differentiated from those with CHC based on activation of distinct sets of immune cells in the liver. Methods We compared profiles of circulating microparticles from patients with NAFL and NASH (n = 67) to those of CHC (n = 42), with healthy individuals (controls) using flow cytometry; the profiles were correlated with inflammation grade and fibrosis stage based on histologic an…