Search results for "PASI"
showing 10 items of 162 documents
Insulin sensitivity and secretion and adipokine profile in patients with Cushing’s disease treated with pasireotide
2018
Purpose: To evaluate the effect of pasireotide on β-cell and adipose function in patients with Cushing’s disease (CD). Methods: Clinical and hormonal parameters, insulin secretion evaluated by HOMA-β and by the area under the curve (AUC2h) of C-peptide during a mixed meal tolerance test and insulin sensitivity, evaluated by the euglycaemic hyperinsulinaemic clamp, were evaluated in 12 patients with active CD, before and after 6 and 12 months of pasireotide. In addition, a panel of adipokines including leptin (Ob), leptin/leptin receptor ratio (Ob/Ob-R ratio), adiponectin, resistin, visfatin, adipocyte fatty acid binding protein (AFABP) and non-esterified fatty acids (NEFAs) was evaluated at…
Working memory capacity affects trade-off between quality and quantity only when stimulus exposure duration is sufficient : Evidence for the two-phas…
2019
AbstractThe relation between visual working memory (VWM) capacity and attention has attracted much interest. In this study, we investigated the correlation between the participants’ VWM capacity and their ability to voluntarily trade off the precision and number of items remembered. The two-phase resource allocation model proposed by Ye et al. (2017) suggests that for a given set size, it takes a certain amount of consolidation time for an individual to control attention to adjust the VWM resources to trade off the precision and number. To verify whether trade-off ability varies across VWM capacity, we measured each individual’s VWM capacity and then conducted a colour recall task to examin…
Long-term safety and efficacy of subcutaneous pasireotide in patients with Cushing’s disease: interim results from a long-term real-world evidence st…
2019
Abstract Purpose Clinical trials have demonstrated the favorable efficacy/safety profile of pasireotide in patients with Cushing’s disease (CD). We report interim long-term results of an ongoing real-world evidence study of subcutaneous pasireotide in patients with CD. Methods Adults with CD receiving pasireotide, initiated before (prior-use) or at study entry (new-use), were monitored for ≤ 3 years during a multicenter observational study (http://clinicaltrials.gov identifier NCT02310269). Primary objective was to assess long-term safety of pasireotide alone or with other CD therapies. Results At the time of this interim analysis, 127 patients had received pasireotide (new-use, n = 31; pri…
The medical treatment with pasireotide in Cushing’s disease: an Italian multicentre experience based on “real-world evidence”
2019
A phase III study has demonstrated that 6-month pasireotide treatment induced disease control with good safety in 15–26% of patients with Cushing’s disease (CD). The aim of the current study was to evaluate the 6-month efficacy and safety of pasireotide treatment according to the real-world evidence. Thirty-two CD patients started pasireotide at the dose of 600 µg twice a day (bid) and with the chance of up-titration to 900 µg bid, or down-titration to 450 or 300 µg bid, on the basis of urinary cortisol (UC) levels or safety. Hormonal, clinical and metabolic parameters were measured at baseline and at 3-month and 6-month follow-up, whereas tumour size was evaluated at baseline and at 6-mont…
Efficacy, safety and quality of life of calcipotriol/betamethasone dipropionate (Dovobet (R)) versus calcipotriol (Daivonex (R)) in the treatment of …
2007
Objective: A clinical trial was performed to evaluate the efficacy, speed of response, side effects and quality of life of patients treated with calcipotriol/betamethasone dipropionate (Dovobet (R)) for 4 weeks followed by maintenance with calcipotriol for 8 weeks (group A) versus calcipotriol (Daivonex (R)) alone for 12 weeks (group B) for the treatment of psoriasis. Materials and methods: A total of 150 patients were enrolled and randomized to groups A and B. PASI and Skindex-29 were considered the outcome measures. Results: Ninety-six patients completed the trial. At weeks 2 and 4, both groups showed a significant clinical improvement compared to baseline; group A demonstrated a higher c…
Una condición extraordinariamente corporal
2021
Es ya un tópico, aquél que establece una relación entre la obra de Montaigne y la de Descartes, bien como adversarios, bien como precedente el uno del otro o como alternativas por relación al concepto de sujeto, que no llegaron a formular plenamente con sus características actuales. Sin embargo, al hilo del estudio del papel del cuerpo en ambos pensadores trataremos de mostrar, primero, su cercanía contextual y, luego, sus filiaciones conceptuales. Ambos autores están mucho más cerca de lo que suele creerse y las deudas intelectuales de Descartes con Montaigne se resumen, además, en una noción de individuo realmente existente y una concepción de la “vida” como alternativa a la filosofía tra…
Mindfulness y duelo: programa MADED, mindfulness para la aceptación del dolor, las emociones y el duelo
2020
Objective: to design a psychological intervention protocol for the accompaniment of pain and emotions in the grieving process based on attention and compassion. Method: mourners over 18 years of age, who have lost their family member at least 6 months ago, who are in phase 2 or 3 of the grieving process and who have no previous mental health problems, will be included. They will be evaluated after signing the informed consent, by means of: the Mindfulness Questionnaire, the Life Satisfaction Questionnaire, the Vitality Questionnaire, the Hospital Anxiety and Depression Scale, the Positive and Negative Affect Scale and the Complicated Grief Inventory. Descriptive statistics, Cohen’s t-test f…
Incretin Response to Mixed Meal Challenge in Active Cushing’s Disease and after Pasireotide Therapy
2022
Cushing’s disease (CD) causes diabetes mellitus (DM) through different mechanisms in a significant proportion of patients. Glucose metabolism has rarely been assessed with appropriate testing in CD; we aimed to evaluate hormonal response to a mixed meal tolerance test (MMTT) in CD patients and analyzed the effect of pasireotide (PAS) on glucose homeostasis. To assess gastro-entero-pancreatic hormones response in diabetic (DM+) and non-diabetic (DM–) patients, 26 patients with CD underwent an MMTT. Ten patients were submitted to a second MMTT after two months of PAS 600 µg twice daily. The DM+ group had significantly higher BMI, waist circumference, glycemia, HbA1c, ACTH le…
Evaluación de una Intervención Mindfulness en Equipos de Cuidados Paliativos
2018
Resumen: El objetivo de este estudio es evaluar los resultados de un programa breve de entrenamiento en mindfulness sobre la atención plena, la autocompasión y la calidad de vida profesional en equipos de cuidados paliativos. Para ello se llevó a cabo un estudio preexperimental pre-post. Participaron 36 profesionales de equipos de cuidados paliativos de Madrid (España). Se midió mindfulness, autocompasión y calidad de vida profesional. Las mediciones se realizaron al inicio y a las dos semanas de finalizada la intervención, que duró seis semanas. Los resultados de aplicación del programa se evaluaron mediante análisis de varianza multivariados (MANOVA). Tras la intervención se observó una m…
MHC class I antigen processing pathway defects, ras mutations and disease stage in colorectal carcinoma
2003
Colorectal tumorigenesis has been associated with the progressive acquisition of a variety of genetic alterations. These include mutations of the Ki-ras proto-oncogene in codons 12 and 13, which account for 85% of genetic changes in colorectal cancer. In murine in vitro models of oncogenic transformation, an association between ras-mediated transformation and downregulation of different components of the MHC class I antigen processing machinery (APM) has been described. In order to investigate whether this association also exists in human tumors, 10 cases of high-grade intraepithelial neoplasia (HIN), as well as primary tumors and autologous lymph node metastases from 42 patients with color…