Search results for "PASI"

MON-445 Long-Term Results of an Ongoing Non-Interventional, Real-World Observational Study of Pasireotide SC in Cushing's Disease

2019

Abstract Background: Clinical trials have shown that subcutaneous (sc) pasireotide effectively decreases urinary free cortisol (UFC), improves signs/symptoms and has a favorable safety profile in patients with Cushing’s disease (CD). We describe interim long-term safety and efficacy results of an ongoing multicenter observational study of pasireotide sc in real-world clinical practice for CD (NCT02310269). Methods: This study aims to enroll 100-200 adults with CD for whom surgery has failed or is not an option. Eligible patients could have started pasireotide before (prior use) or at (new use) study entry. Primary endpoint: incidence of pasireotide-related adverse events (AEs) and serious A…

El rol cambiante de los recursos personales en la empleabilidad percibida de los jóvenes en diferentes condiciones del mercado de trabajo

2020

Personal resources and labor market are factors that contribute to perceived employability. However, how changing labor market conditions affect the relationship between personal resources like career enhancing strategies, personal initiative, and career passivity with self-perceived employability remains unclear. Recent events in Spain give an opportunity to examine if personal resources predict perceived employability differently during normal and harsh labor conditions. Two representative samples of young people were surveyed during a normal labor condition (in 2008, before the big recession, n = 1,992) and a harsh condition (in 2011, with 46% young unemployment rate, n = 1,208). …

Pasireotide versus pituitary surgery: a retrospective analysis of 12 months of treatment in patients with Cushing’s disease

2017

Pituitary surgery represents the first-line treatment for most patients with Cushing’s disease (CD). In the case of surgery failure, additional treatment options are required. Pasireotide has shown favourable results in the first-line treatment of patients with CD, who are not candidates for surgery or in the second-line when surgery has failed. The aim of the current study is to compare the effects of surgery and pasireotide treatment in a cohort of patients with CD, and to evaluate the differences in response rate in terms of hormonal and clinical control, and improvement of metabolic complications

Functional deficiencies of components of the MHC class I antigen pathway in human tumors of epithelial origin

2000

An association between oncogenic transformation and repression of different components of the MHC class I antigen processing machinery (APM) have been described in murine model systems. In order to discover whether a similar correlation exists, human tumor cell lines of distinct histology with altered ras protein were analyzed for the expression of APM components utilizing RT-PCR and Western blot analyses. A heterogeneous expression pattern of MHC class I antigens, TAP peptide transporter, proteasome subunits, proteasome activator PA28 and the chaperones calnexin, calreticulin as well as tapasin was displayed by these tumor cell lines. Single or combined deficiencies in the expression and/o…

The annular decay property and capacity estimates for thin annuli

2016

We obtain upper and lower bounds for the nonlinear variational capacity of thin annuli in weighted $\mathbf{R}^n$ and in metric spaces, primarily under the assumptions of an annular decay property and a Poincar\'e inequality. In particular, if the measure has the $1$-annular decay property at $x_0$ and the metric space supports a pointwise $1$-Poincar\'e inequality at $x_0$, then the upper and lower bounds are comparable and we get a two-sided estimate for thin annuli centred at $x_0$, which generalizes the known estimate for the usual variational capacity in unweighted $\mathbf{R}^n$. Most of our estimates are sharp, which we show by supplying several key counterexamples. We also character…

HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway.

2004

Abstract Because of its amplification and/or overexpression in many human tumors, the HER-2/neu proto-oncogene represents an attractive target for T-cell-mediated vaccination strategies. However, overexpression of oncogenes is often associated with defective expression of components of the MHC class I antigen-processing machinery (APM), thereby resulting in an immune escape phenotype of oncogene-transformed cells. To determine whether HER-2/neu influences the MHC class I antigen-processing pathway, the expression pattern of different APM components was examined in murine in vitro models of constitutive and tetracycline-controlled HER-2/neu expression. In comparison with HER-2/neu− control c…

Candau Chacon, María Luisa (coord.): Pasiones en femenino. Europa y América, 1600-1950

2020

The Ricardian system: a graphical exposition

2017

Ever since its publication, Pasinetti’s 1960 paper has been a primary reference for all scholars interested in Ricardian economics. However, Kaldor's 1955-6 diagram is a very effective tool for depicting the salient features of the Ricardian system and its full heuristic potentialities are still under-explored. Accordingly, we give it pride of place in this paper. In what follows, after a brief presentation of a slightly amended version of Kaldor’s original diagram, we show how this diagram may be modified to represent Pasinetti’s two-sector model of a closed economy. Next we use it to analyse alternative consumption patterns. Finally, we employ a variant of Kaldor’s diagram to study a two-…

IL PARTENOLIDE INDUCE MORTE CELLULARE CASPASI-INDIPENDENTE IN CELLULE DI OSTEOSARCOMA UMANO MG63

2011

La fabbrica del complesso ecclesiastico degli Olivetani

2019

Memorabile è la storia di questo monastero e della sua chiesa sia per i molti avvenimenti nella sua fondazione, sia per le varie mutazioni avvenute negli anni e nei secoli seguenti. I lavori iniziarono nel 1509, approvati con bolla pontificia di Papa Giulio II. Il complesso monumentale di Santa Maria dello Spasimo sorge nel cuore del Mandamento dei Tribunali, nel quartiere della Kalsa, ai bordi di quella che fu la cittadella araba (al-Halisah), per l’impegno di Jacopo Basilicò, che volle rispettare le volontà testamentarie della moglie di edificare una chiesa dedicata alla Madonna Addolorata. Il Basilicò per celebrarla degnamente, commissiona al grande Raffaello da Urbino, un dipinto raffig…