Search results for "PATHOLOGY"
showing 9 items of 8489 documents
Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane
2021
Herpes simplex virus capsids are assembled and packaged in the nucleus and move by diffusion through the nucleoplasm to the nuclear envelope for egress. Analyzing their motion provides conclusions not only on capsid transport but also on the properties of the nuclear environment during infection. We utilized live-cell imaging and single-particle tracking to characterize capsid motion relative to the host chromatin. The data indicate that as the chromatin was marginalized toward the nuclear envelope it presented a restrictive barrier to the capsids. However, later in infection this barrier became more permissive and the probability of capsids to enter the chromatin increased. Thus, although …
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
Anatomic and functional follow-up of patients with an idiopathic epiretinal membrane and a preserved visual acuity
2013
Purpose: To determine the anatomic and functional retinal modifications in patients with an idiopathic epiretinal membrane (ERM) and a preserved visual acuity (VA).Methods: Monocentric, prospective study in 24 eyes of 24 patients with an ERM and a VA better than 20/25. Recorded data were best corrected VA on ETDRS scale, retinal anatomic lesions on spectral-domain OCT, retinal sensitivities on microperimetry and macular and foveal thicknesses at 0 and 6 months.Results: At inclusion, mean VA was 84 ± 5 letters, mean macular sensitivity was 14.0 ± 1.4 decibels (dB) and mean foveal sensitivity was 14,4 ± 1,5 dB. Mean macular thickness was 351 ± 34 µm and mean foveal thickness was 348 ± 66 µm. …
Motion perception in early glaucoma
2013
Purpose: The aim of our study was to underline the changes in the movement perception for early glaucoma. Our working hypothesis consisted in inquiring if the impairment of the magnocellular pathway may modify the movement perception capabilities in the visual field, more particularly in its peripheral area.Methods: We included 14 healthy subjects and 14 patients with early primary open angle glaucoma. A moving target was presented on a semicircular screen (1.8 m diameter); participants were asked to localize the Ending Point (EP) of each movement. Each stimulus consisted in a white dot (0,72° of diameter) moving horizontally with the imposed velocity profile. Two different laws of motion w…
H&E Multi-Laboratory Staining Variance Exploration with Machine Learning
2022
In diagnostic histopathology, hematoxylin and eosin (H&E) staining is a critical process that highlights salient histological features. Staining results vary between laboratories regardless of the histopathological task, although the method does not change. This variance can impair the accuracy of algorithms and histopathologists’ time-to-insight. Investigating this variance can help calibrate stain normalization tasks to reverse this negative potential. With machine learning, this study evaluated the staining variance between different laboratories on three tissue types. We received H&E-stained slides from 66 different laboratories. Each slide contained kidney, skin, and colon tissue sampl…
Predominance of Type 1 Innate Lymphoid Cells in the Rectal Mucosa of Patients With Non-Celiac Wheat Sensitivity: Reversal After a Wheat-Free Diet.
2016
OBJECTIVES: Non-celiac wheat sensitivity (NCWS) is defined as a reaction to ingested wheat after exclusion of celiac disease and wheat allergy. As its pathogenesis is incompletely understood, we evaluated the inflammatory response in the rectal mucosa of patients with well-defined NCWS. METHODS: The prospective study included 22 patients with irritable bowel syndrome (IBS)-like clinical presentation, diagnosed with NCWS by double-blind placebo-controlled challenge. Eight IBS patients not improving on wheat-free diet were used as controls. Two weeks after oral challenge was performed with 80 grams of wheat daily, cells were isolated from rectal biopsies and thoroughly characterized by fluore…
Bladder tumours in children: An interesting case report of TCC with a partial inverted growth pattern.
2014
Bladder urothelial carcinoma is typically a disease of older individuals and rarely occurs below the age of 40 years. There is debate and uncertainty in the literature regarding the clinicopathologic and prognostic characteristics of bladder urothelial neoplasms in younger patients compared with older patients, although no consistent age criteria have been used to define "younger" age group categories. We report on a 16 years old girl with transitional cell carcinoma of the bladder with a partial inverted growth pattern who presented with gross hematuria. Ultrasonography revealed a papillary lesion in the bladder; cystoscopic evaluation showed a 15 mm papillary lesion with a thick stalk loc…
Intraocular pressure and central corneal thickness in an old French population: The MONTRACHET study
2013
Purpose: To describe the distribution of intraocular pressure (IOP) and central corneal thickness (CCT) in an old French population. Methods: About 9000 individuals 65 years and older were included in the 3C cohort study since 1999 in 3 French cities (Bordeaux, Dijon and Montpellier). In Dijon, an additional ophthalmic examination was performed 10 years after the initial inclusions to assess the relation between systemic age-related diseases and eye diseases in the MONTRACHET Study (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases). In this population-based stuy a thorough eye examination and a questionnaire were undertaken in each participant. Intraocular pressure (IOP) w…
INFLUENCIA DE FACTORES FAMILIARES Y PERSONALES EN LA EVOLUCIÓN NEGATIVA DEL TDAH
2016
Abstract.INFLUENCE OF PERSONAL AND FAMILY FACTORS ON THE NEGATIVE COURSE OF ADHDObjective. To study the effect of the cumulative adversity on the course of ADHD symptoms, associated problems and dysfunctionality of ADHD children. Method. 61 families of children with a clinical diagnosis of ADHD combined subtype were evaluated on two different times (Time I: mean age = 8.7; Time II: mean age = 11). We developed a personal risk index (high levels of ADHD symptoms, high number of associated problems, presence of oppositionism, stressful child characteristics and family history of ADHD), a family risk index (presence of mothers’ psychopathology, high parental stress and dysfunctional discipline…