Search results for "PBD"
showing 10 items of 21 documents
Preparation and characterization of dummy-template molecularly imprinted polymers as potential sorbents for the recognition of selected polybrominate…
2018
The main aim of this work was to conduct the preliminary/basic research concerning the preparation process of a new dummy molecularly imprinted polymer (DMIP) materials. Developed DMIPs were proposed as a sorption material in solid-phase extraction (SPE) technique for recognition of selected low mass polybrominated diphenyl ethers (PBDEs) – PBDE-47 and PBDE-99. Four new DMIPs were synthesized employing bulky polymerization technique by application of structural analogue of low mass PBDEs - 4,4′-Dihydroxydiphenyl ether, as a dummy template. The DMIPs and corresponding non-imprinted polymers were prepared using different functional monomers: methacrylic acid; methyl methacrylate and different…
Position based constraint enforcement in game physics
2016
La simulación de sistemas mecánicos para videojuegos y otras aplicaciones interactivas impone restricciones importantes en cuanto a estabilidad, flexibilidad en las escenas y complejidad computacional. En los últimos años han aparecido varias estrategias para la resolución de sistemas mecánicos con restricciones. Algunas de las más populares en el desarrollo de videojuegos usan solamente la posición de las partículas y un algoritmo de proyección sobre la variedad definida por las restricciones, evitando la manipulación de la primera derivada del sistema (las velocidades). De esta forma se consigue una gran estabilidad numérica. El principal defecto de estos métodos es su dependencia en pará…
Emerging contaminants related to the occurrence of forest fires in the Spanish Mediterranean
2017
Forest fires can be a source of contamination because, among others, of the use of chemicals to their extinction (flame retardants, FRs), or by the production of Polycyclic Aromatic Hydrocarbons (PAHs) derived from high temperature alteration of organic matter. Up to our knowledge, this study is the first to assess the direct (PAHs 16 on the USA EPA's priority list), and indirect [tri- to hepta- brominated diphenyl ethers (PBDEs), organophosphorus flame retardants (PFRs) and perfluoroalkyl substances (PFASs)] contamination related to forest fires. The abundance and distribution of these contaminants were monitored on two Mediterranean hillslopes, one burned and one unburned, near Azuébar (S…
MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate
2019
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethyl-benzofuran-2-carboxylic acid ethyl ester (designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1…
Design of experiment approach for the optimization of polybrominated diphenyl ethers determination in fine airborne particulate matter by microwave-a…
2015
Abstract A sensitive and selective procedure for the determination of 12 polybrominated diphenyl ethers (BDE-28, BDE-49, BDE-47, BDE-66, BDE-100, BDE-119, BDE-99, BDE-155, BDE-154, BDE-153, BDE-139 and BDE-183) in airbone particulate matter (PM2.5) at trace level has been developed. The proposed method includes extraction PM2.5-bound PBDEs by microwave-assisted extraction (MAE) followed by gel permeation chromatography (GPC) clean-up and determination by GC-MS/MS using a programmed temperature vaporizer (PTV) in large volume injection (LVI) mode to introduce the sample to the chromatographic system. A design of experiment (DoE) approach was used for the optimization of large volume injectio…
Analytical and numerical comparison of position based methods versus physics based formulation of mechanical systems
2017
La simulación de sistemas mecanicos para videojuegos y otras aplicaciones interactivas impone restricciones importantes como estabilidad, flexibilidad en las escenas, y complejidad computacional. En los últimos años han aparecido múltiples estrategias de resolución para sistemas mecánicos con restricciones. Algunos de los más populares en el ámbito de videojuegos únicamente usan las posiciones de las partículas y un algoritmo de proyección sobre la variedad definida por las restricciones, evitando la manipulación de la primera derivada del sistema (las velocidades), obteniendo así gran estabilidad numérica. El principal problema de estos métodos es la dependencia en parámetros no físicos, d…
Assessment of building energy modelling studies to meet the requirements of the new Energy Performance of Buildings Directive
2020
Abstract The cost optimal method (COM) as applied in the Energy Performance of Buildings Directive (EPBD) uses “non-calibrated deterministic reference buildings (RBs)”. Such RBs are defined with single envelope and equipment parameter values, for which calibration with actual building stock energy performance (EP) is not undertaken. Thus, it is not possible to visualise the effect of uncertainties or diversity in the input parameters on cost-optimal level benchmarks and to verify the choice of RBs. The paper proposes an update to the COM via use of “Probabilistic Bayesian calibrated RBs” to handle uncertainties and produce more realistic cost optimal levels to support policy makers in devis…
Polymer aging affects the bioavailability of microplastics-associated contaminants in sea urchin embryos
2022
Microplastics (MPs) in the marine environment undergo complex weathering factors that can affect their ability to interact with different coexisting environmental contaminants (termed here co-contaminants). In this study, the influence of artificially aging using UV on the sorption of a complex mixture of co-contaminants onto MPs was investigated in order to provide meaningful hypotheses on their individual and combined toxicities on sea urchin embryos. A mixture of artificially aged MPs (PS particles and PA microfibers) combined with 2,2′ ,4,4′ - tetrabromodiphenyl ether (BDE-47), or Cd or Cu, both alone and in a mix, were used to expose embryos of Paracentrotus lividus. The effects of pol…
Bromēto liesmas slāpētāju noteikšana medību gaļas paraugos ar augstas izšķirtspējas masspektrometrijas metodēm
2017
Bromēto liesmas slāpētāju noteikšanas medību gaļas paraugos ar augstas izšķirtspējas masspektrometrijas metodēm. Bāliņš Rolands, zinātniskais vadītājs: Dr. ķīm., Dzintars Začs, konsultante: Ķīm. maģ., doktorante Jekaterina Rjabova. Maģistra darbs, 47 lappuses, 9 attēli, 21 tabula, 30 literatūras avoti, 2 pielikumi. Latviešu valodā. Maģistra darbā ir apkopota literatūra par analizētajiem savienojumiem, to pielietošanu, toksiskumu, izplatību dabā un to analīžu metodēm. Iegūtie rezultāti ir apkopoti tabulu un diagrammu veidā. Darbā tika veikta bromēto liesmas slāpētāju tetrabrom bisfenola A (TBBPA), heksabromciklododekāna (HBCDD) un polibromēto difenil ēteru (PBDEs) noteikšana medījumu gaļas p…
Invisible pollution : emerging marine pollutants
2021
Since the start of the Anthropocene, the planet has been threatened by a number of risks associated with human activity. Among them, chemical pollution is posing conceptual and technical challenges that are particularly difficult to characterise on a global scale. We must ask ourselves, what is a pollutant? What properties are relevant in their definition? Studies on the abundance, persistence, mobility in the environment, and bioaccumulation potential of the chemical compounds we use every day are changing the paradigm of what we consider pollutants. Thus, compounds that do not cause acute toxicity can still be dangerous for the ecosystem when they continually reach the environment, exist …