Search results for "PD"
showing 10 items of 1971 documents
Inhibition of Saccharomyces cerevisiae Pdr5p by a natural compound extracted from Brazilian Red Propolis
2011
Multidrug resistance of cancer cells and pathogenic microorganisms leading to the treatment failure of some forms of cancer or life-threatening bacterial or fungal infections is often caused by the overexpression of multidrug efflux pumps belonging to the ATP-binding cassette transporters superfamily. The multidrug resistance of fungal cells often involves the overexpression of efflux pumps belonging to the pleiotropic drug resistance (PDR) family of ABC transporters. Possibly the best-studied fungal PDR transporter is the multidrug resistance transporter Pdr5p of Saccharomyces cerevisiae. Some research groups have been searching for new inhibitors of these efflux pumps in order to alleviat…
New lifetime measurements in 109 Pd and the onset of deformation at N = 60
2015
Several new subnanosecond lifetimes were measured in 109Pd using the fast-timing βγγ (t) method. Fission fragments of the A = 109 mass chain were produced by bombarding natural uranium with 30 MeV protons at the Jyvaskyl ¨ a Ion Guide Isotope Separator On-Line (IGISOL) facility. Lifetimes were obtained for excited states ¨ in 109Pd populated following β decay of 109Rh. The new lifetimes provide some insight into the evolution of nuclear structure in this mass region. In particular, the distinct structure of the two low-lying 7/2+ states occurring systematically across the Pd isotopic chain is supported by the new lifetime measurements. The available nuclear data indicate a sudden increase i…
Effect of consumers’ origin on perceived sensory quality, liking and liking drivers: A cross-cultural study on European cheeses
2021
Abstract We aim at studying consumers’ Perceived Sensory Quality (PSQ) concept. We manipulated a priori both familiarity (contrast local vs. foreign cheeses) and quality level (contrast PDO or traditional cheeses vs. their non-PDO and/or industrial counterpart). The study was run in four European countries. Thus, eight cheeses (one PDO or traditional cheese and one non-PDO cheese from each of the four European countries) were assessed by a total of 438 consumers (from 100 to 120 consumers from each region) in terms of PSQ and liking. The cheeses were also described by a trained panel. PSQ depended on both consumers’ and cheeses’ origin. The main finding is that in the three countries with P…
Modyfikowane ftalocyjaniny dla diagnozowania oraz terapii fotodynamicznej nowotworów
2016
Terapie przeciwnowotworowe powinny charakteryzować się wysoką skutecznością przy możliwie ograniczonych skutkach ubocznych. Obiecującą metodą wydaje się być terapia fotodynamiczna (PDT). Dobrą efektywność terapii uzyskuje się, stosując lipofilowe foto-uczulacze, kumulujące się w błonie komórkowej. Dodatkowo efektywność terapii fotodyn-amicznej można zwiększyć, stosując liposomy jako nośniki leków. Rolę fotouczulaczy (PS) dla terapii PDT mogą pełnić modyfikowane ftalocyjaniny (MPc). W pracy koncentrowano się na zbadaniu możliwości penetracji błony fosfolipidowej przez ftalocyjaninę miedzi o 4 podstawnikach 2,4-bis(1,1-dimetylopropylo)fenoksylowych (CuPc-TM), bezmetaliczną ftalocyjaninę o 4 p…
Lipofilowe ftalocyjaninydla terapii fotodynamicznej PDT
2015
Terapia fotodynamiczna (PDT) jest nowym typem terapii chorób, zwłaszcza nowo-tworowych, wykorzystujących światłoczułe związki, które po naświetleniu światłem o odpowiedniej długości fali mają zdolność do wytwarzania reaktywnych form tlenu, które niszczą chore komórki. Szczególnie interesujące wydają się funkcjonalizowane diftalo-cyjaniny lantanowców, gdyż wykazują one silną absorpcję promieniowania o długości fali powyżej 600 nm, co jest ważne dla terapii PDT. Efektywność PDT jest również zależna od miejsca lokalizacji fotouczulacza w komórce, co jest bezpośrednio związane z jego budową chemiczną. Fotouczulaczelipofilowe stosunkowo łatwo penetrują warstwę fosfolipidową i mają tendencję do k…
Local regularity estimates for general discrete dynamic programming equations
2022
We obtain an analytic proof for asymptotic H\"older estimate and Harnack's inequality for solutions to a discrete dynamic programming equation. The results also generalize to functions satisfying Pucci-type inequalities for discrete extremal operators. Thus the results cover a quite general class of equations.
Smoke exposure affects gelatinase A and B activity levels in two lung epithelial cell lines
2006
The Value of a Complete Blood Count (CBC) for Sepsis Diagnosis and Prognosis.
2021
Sepsis represents an important global health burden due to its high mortality and morbidity. The rapid detection of sepsis is crucial in order to prevent adverse outcomes and reduce mortality. However, the diagnosis of sepsis is still challenging and many efforts have been made to identify reliable biomarkers. Unfortunately, many investigated biomarkers have several limitations that do not support their introduction in clinical practice, such as moderate diagnostic and prognostic accuracy, long turn-around time, and high-costs. Complete blood count represents instead a precious test that provides a wealth of information on individual health status. It can guide clinicians to early-identify …
Systematic Study of a Library of PDMAEMA-Based, Superparamagnetic Nano-Stars for the Transfection of CHO-K1 Cells.
2017
The introduction of the DNA into mammalian cells remains a challenge in gene delivery, particularly in vivo. Viral vectors are unmatched in their efficiency for gene delivery, but may trigger immune responses and cause severe side-reactions. Non-viral vectors are much less efficient. Recently, our group has suggested that a star-shaped structure improves and even transforms the gene delivery capability of synthetic polycations. In this contribution, this effect was systematically studied using a library of highly homogeneous, paramagnetic nano-star polycations with varied arm lengths and grafting densities. Gene delivery was conducted in CHO-K1 cells, using a plasmid encoding a green fluore…
Immobilized Pd on magnetic nanoparticles bearing proline as a highly efficient and retrievable Suzuki–Miyaura catalyst in aqueous media
2015
A magnetically retrievable nanocatalyst was evaluated for amicrowave assisted Suzuki–Miyaura reaction in aqueous media.Excellent yields and conversions were obtained with low Pd loadings(down to 0.01 mol% Pd). It was stable up to 6 months in waterunder aerobic conditions and efficiency remained unaltered evenafter 7 repeated cycles. Refereed/Peer-reviewed