Search results for "PD"
showing 10 items of 1971 documents
A Dirichlet problem for the Laplace operator in a domain with a small hole close to the boundary
2016
We study the Dirichlet problem in a domain with a small hole close to the boundary. To do so, for each pair $\boldsymbol\varepsilon = (\varepsilon_1, \varepsilon_2 )$ of positive parameters, we consider a perforated domain $\Omega_{\boldsymbol\varepsilon}$ obtained by making a small hole of size $\varepsilon_1 \varepsilon_2 $ in an open regular subset $\Omega$ of $\mathbb{R}^n$ at distance $\varepsilon_1$ from the boundary $\partial\Omega$. As $\varepsilon_1 \to 0$, the perforation shrinks to a point and, at the same time, approaches the boundary. When $\boldsymbol\varepsilon \to (0,0)$, the size of the hole shrinks at a faster rate than its approach to the boundary. We denote by $u_{\bolds…
Discontinuous Gradient Constraints and the Infinity Laplacian
2012
Motivated by tug-of-war games and asymptotic analysis of certain variational problems, we consider a gradient constraint problem involving the infinity Laplace operator. We prove that this problem always has a solution that is unique if a certain regularity condition on the constraint is satisfied. If this regularity condition fails, then solutions obtained from game theory and $L^p$-approximation need not coincide.
Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of the novel enzyme replacement therapy avalglucosidase alfa (neoG…
2019
This multicenter/multinational, open-label, ascending-dose study (NCT01898364) evaluated safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of repeat-dose avalglucosidase alfa (neoGAA), a second-generation, recombinant acid α-glucosidase replacement therapy, in late-onset Pompe disease (LOPD). Patients ≥18 years, alglucosidase alfa naïve (Naïve) or previously receiving alglucosidase alfa for ≥9 months (Switch), with baseline FVC ≥50% predicted and independently ambulatory, received every-other-week avalglucosidase alfa 5, 10, or 20 mg/kg over 24 weeks. 9/10 Naïve and 12/14 Switch patients completed the study. Avalglucosidase alfa was well-tolerated; no deaths…
Angular analysis of charged and neutral B → Kμ + μ − decays
2014
The angular distributions of the rare decays B → K+µ+µ- and B0 → K0 <inf>a</inf>Sμ+μ- are studied with data corresponding to 3 fb-1 of integrated luminosity, collected in proton-proton collisions at 7 and 8TeV centre-of-mass energies with the LHCb detector. The angular distribution is described by two parameters, FH and the forward-backward asymmetry of the dimuon system AFB, which are determined in bins of the dimuon mass squared. The parameter F<inf>H</inf> is a measure of the contribution from (pseudo)scalar and tensor amplitudes to the decay width. The measurements of A<inf>FB</inf> and F<inf>H</inf> reported here are the most precise to d…
Aspartilproteāžu inhibitoru sintēze
2018
Aspartilproteāžu inhibitoru sintēze. Žogota R., zinātniskais vadītājs Prof., Dr. chem. Sūna E. Bakalaura darbs, 132 lappuses, 61 attēls, 8 tabulas, 59 literatūras avoti, 3 pielikumi. Latviešu valodā. Bakalaura darba ietvaros ir sintezēti 42 aspartilproteāžu inhibitori, kas ir potenciāli pret-malārijas zāļu vielu kandidāti. Apkopota informācija par iegūto inhibitoru struktūras-aktivitātes likumsakarībām.
GOLD Staging System is Appropriate to Predict Mortality in Older People With Chronic Obstructive Pulmonary Disease
2018
Abstract Introduction In the new GOLD classification the reduction of FEV1, expressed as percentage of predicted value (FEV1PP), is considered an important prognostic factor. However, the use of FEV1PP may introduce bias, especially if based on equations derived from populations different from the one under study. We evaluated how well the GOLD classification stratifies the mortality risk when FEV1PP is based on an equation developed in the same population that gave rise to cases, externally developed equations, or as FEV1 divided by cubed height (FEV1/Ht3). Methods We studied 882 participants aged ≥65 years. Bronchial obstruction was defined using a fixed cut-off of 0.7 for FEV1/FVC. Predi…
Emocionālā statusa un saiknes ar jaundzimušo salīdzinājums sievietēm pēc dzemdībām pa dabiskiem ceļiem un pēc ķeizargrieziena operācijas
2017
Pētījuma mērķis bija izpētīt, vai dzemdību veids – ķeizargrieziens vai dzemdības pa dabīgiem ceļiem, ietekmē mātes pēcdzemdību psiho-emocionālo status un mātes-bērna saiknes izveidošanos. Mātes emocionālais stāvoklis tika novērtēts ar tā saucamo Edinburgas Pēcdzemdību Depresijas Skalu (EPDS). Skala tika iekļauta pētījumā izmantotā anketā, kuru aizpildīja pētījuma dalībnieces. Ar EPDS nosaka mātes risku uz pēcdzemdību depresijas attīstību, kur iegūto punktu skaitu interpretē sekojoši: 0-9 punkti nozīmē zemu, 9-13 vidējo un >13 punktiem augstu risku uz pēcdzemdību depresijas attīstību. Pēcdzemdību perioda pirmās nedēļas laikā siviete stresa rezultātā var piedzīvot tā saucamo “Baby Blues”, jeb…
The eio proposal for a directive and mafia trials: Striving for balance between efficiency and procedural guarantees
2013
PD EIO could mark a turning point in the development of “European criminal procedure.” The Proposal will obtain evidence in cross-border cases and is particularly suitable for investigations on the subject of international organized crime. From the long gestation period and the contents of the Proposal emerges, however, the difficulty of making a balance between the investigation of crimes and the guarantees of the individuals involved. The use of collected of evidence from different legal systems is often an overly neglected aspect. Doubt surrounds the regulation of banking instruments, the rules on wiretapping, and all provisions for undercover investigations.
Pro-and anti-fibrotic molecule balance in the bronchial mucosa of stable COPD patients
2015
Background: The mechanisms of inducing fibrotic events and remodeling in the airways of COPD are incompletely studied. Objectives: To investigate the expression of cytokines involved in the pro- and anti-fibrotic events in stable COPD. Methods: Expression of CTGF, TGFβ1-2-3, TGFβRI, TGFβRII, LTBP-1, TRAP-1, BAMBI, PP2Cα, Smad2-3-6-7, pSmad2, pSmad3, pro-collagen-I and collagen-I was measured in the bronchial mucosa using immunohistochemistry and RT-qPCR. Results: TGFβ1 was increased in the epithelium and TGFβ3 in the submucosa of healthy smokers and mild/moderate COPD compared to healthy non-smokers. In all smokers and patients with COPD TGFβ3+ cells in the submucosa correlated significantl…
A bending theory of thermoelastic diffusion plates based on Green-Naghdi theory
2017
Abstract This article is concerned with bending plate theory for thermoelastic diffusion materials under Green-Naghdi theory. First, we present the basic equations which characterize the bending of thin thermoelastic diffusion plates for type II and III models. The theory allows for the effect of transverse shear deformation without any shear correction factor, and permits the propagation of waves at a finite speed without energy dissipation for type II model and with energy dissipation for type III model. By the semigroup theory of linear operators, we prove the well-posedness of the both models and the asymptotic behavior of the solutions of type III model. For unbounded plate of type III…