Search results for "PD"

showing 10 items of 1971 documents

Death in hospital following ICU discharge: insights from the LUNG SAFE study

2021

Abstract Background To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with tre…

MaleARDSLUNG SAFEhealth care facilities manpower and servicesAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Hospital survival; ICU discharge; LUNG SAFEKaplan-Meier EstimateCritical Care and Intensive Care MedicineAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Hospital survival; ICU discharge; LUNG SAFE;0302 clinical medicineRisk Factors030212 general & internal medicineProspective StudiesProspective cohort studyAcute hypoxemic respiratory failureCOPDAcute respiratory distress syndromeICU dischargeMedical emergencies. Critical care. Intensive care. First aidMiddle AgedPatient DischargeLUNG SAFE.Intensive Care Unitsmedicine.anatomical_structureLung safeSOFA scoreFemaleRespiratory InsufficiencyAdultmedicine.medical_specialtyNOHospital survival03 medical and health sciencesSettore MED/41 - ANESTESIOLOGIAmedicineHumansddc:610Risk factorMortalityAgedLungRC86-88.9business.industryResearch030208 emergency & critical care medicinemedicine.diseaseLogistic Modelslnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]Respiratory failureEmergency medicineObservational studybusiness
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Effects of different physical therapy programs on perceived health status in acute exacerbation of chronic obstructive pulmonary disease patients: a …

2017

To evaluate the repercussion of different physical therapy interventions on the perceived health status of chronic obstructive pulmonary disease (COPD) patients during acute exacerbation.Randomized controlled trial. Patients were assigned to: control group (standard medical treatment), controlled breathing + range of motion exercises group or Resistance exercises group. Perceived health status was assessed at baseline and discharge using the EuroQol-5D (EQ-5D) questionnaire. Clinical profile of patients was evaluated at baseline for descriptive purposes.Ninety patients were randomized into the groups. Perceived health status improved significantly in all groups. Significant differences were…

MaleAcute exacerbation of chronic obstructive pulmonary diseasemedicine.medical_specialtyExacerbationVisual analogue scalePsychological interventionBreathing Exerciseslaw.inventionDiagnostic Self EvaluationDiagnostic Self EvaluationPulmonary Disease Chronic Obstructive03 medical and health sciences0302 clinical medicineRandomized controlled trialQuality of lifelawSurveys and QuestionnairesmedicineHumans030212 general & internal medicinePhysical Therapy ModalitiesAgedCOPDbusiness.industryRehabilitationMiddle AgedSymptom Flare Upmedicine.diseaseSelf CareTreatment Outcome030228 respiratory systemQuality of LifePhysical therapyExercise Movement TechniquesFemalebusinessDisability and Rehabilitation
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From Global Initiative for Chronic Obstructive Lung Disease (GOLD) Guidelines to Current Clinical Practice

2006

Background: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines have been promulgated to improve the management of chronic obstructive pulmonary disorder (COPD). Objective: To evaluate the extent to which the current therapeutic approach to COPD conforms to GOLD guidelines. Methods: This was a multicentre observational study of elderly COPD patients enrolled for acute care in general medicine or geriatric wards in tertiary hospitals in Italy in April 2002. Our series consisted of 471 patients >64 years of age consecutively admitted for acute exacerbations of COPD to wards participating in the study. Data describing drugs used prior to exacerbation and prescribed at …

MaleAgingmedicine.medical_specialtyDrug IndustryPharmacological therapyGuidelines as Topicurologic and male genital diseasesPulmonary Disease Chronic ObstructivePharmacotherapyOdds RatiomedicineHumansMulticenter Studies as TopicPharmacology (medical)Practice Patterns Physicians'Intensive care medicineAgedCOPDbusiness.industryRespiratory diseaseTiotropium bromidemedicine.diseaseDrug UtilizationObstructive lung diseaserespiratory tract diseasesClinical PracticeLung diseasePhysical therapyFemaleGuideline AdherenceAcute Exacerbation Tiotropium Methylxanthine Tiotropium Bromide Cumulative Illness Rate ScaleGeriatrics and Gerontologybusinessmedicine.drugDrugs & Aging
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C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) as inflammation markers in elderly patients with stable chronic obstructive pulmona…

2010

Erythrocyte sedimentation rate (ESR) might represent a less expensive alternative to C-reactive protein (CRP) as a marker of systemic inflammation in stable chronic obstructive pulmonary disease (COPD). We tried to verify this hypothesis in 223 consecutive outpatients aged 65 years or more with stable COPD enrolled in a multicenter observational study. Patients were grouped according to normal/increased ESR/CRP values and groups were compared with regard to clinical and laboratory characteristics. Correlations between CRP, ESR and selected variables of interest were assessed by Spearman's ζ-test and multivariate linear regression analysis. CRP was weakly and inversely correlated with the fo…

MaleAgingmedicine.medical_specialtyHealth (social science)AnemiaBlood SedimentationSettore MED/10 - Malattie Dell'Apparato RespiratorioSystemic inflammationSeverity of Illness IndexGastroenterologyPulmonary Disease Chronic ObstructiveInternal medicineBayesian multivariate linear regressionSeverity of illnessmedicineHumansCOPDHypoalbuminemiaAgedInflammationCOPDmedicine.diagnostic_testbiologybusiness.industryC-reactive proteinPrognosismedicine.diseaseSurgeryC-Reactive ProteinErythrocyte sedimentation ratebiology.proteinFemaleGeriatrics and Gerontologymedicine.symptombusinessGerontologyBiomarkersFollow-Up Studies
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The mini nutritional assessment is associated with the perception of dyspnoea in older subjects with advanced COPD

2008

MaleAgingmedicine.medical_specialtymedia_common.quotation_subjectComorbiditySettore MED/10 - Malattie Dell'Apparato RespiratorioRisk AssessmentSeverity of Illness IndexStatistics NonparametricCohort StudiesPulmonary Disease Chronic ObstructiveAge DistributionPhysical medicine and rehabilitationSurveys and QuestionnairesPerceptionSeverity of illnessmedicineHumansSex DistributionAgedProbabilitymedia_commonCOPDAnthropometrybusiness.industryIncidenceIncidence (epidemiology)General MedicineMiddle AgedAnthropometryPrognosismedicine.diseaseSurvival AnalysisComorbidityNutrition DisordersDyspneaNutrition AssessmentPhysical therapyFemalePerceptionBasal MetabolismGeriatrics and GerontologyRisk assessmentbusinessCohort studyDyspnea/diagnosis/*epidemiology
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SARS CoV2 infection _The longevity study perspectives

2021

Graphical abstract

MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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The Gene-Environment Interactions in Respiratory Diseases (GEIRD) Project.

2009

The role of genetic and environmental factors, as well as their interaction, in the natural history of asthma, allergic rhinitis and chronic obstructive pulmonary disease (COPD) is largely unknown. This is mainly due to the lack of large-scale analytical epidemiological/genetic studies aimed at investigating these 3 respiratory conditions simultaneously. The GEIRD project is a collaborative initiative designed to collect information on biomarkers of inflammation and oxidative stress, individual and ecological exposures, diet, early-life factors, smoking habits, genetic traits and medication use in large and accurately defined series of asthma, allergic rhinitis and COPD phenotypes. It is a …

MaleAllergyDatabases FactualRespiratory Tract DiseasesEnvironmental pollutionPulmonary Disease Chronic ObstructiveSurveys and QuestionnairesEpidemiologyImmunology and AllergyLongitudinal StudiesgenesCOPDeducation.field_of_studyData CollectionGeneral MedicineNutrition SurveysNatural historyPhenotypeItalyData Interpretation StatisticalFemalecase-controlmedicine.medical_specialtyRhinitis Allergic PerennialImmunologyPopulationEnvironmentchronic obstructive pulmonary diseaserhinitisBiasmedicineHumanseducationinflammatory biomarkersAsthmaallergic rhinitisPublic Sectorbusiness.industryCase-control studyRhinitis Allergic Seasonalmedicine.diseaseAsthmagenes chronic obstructive pulmonary disease asthma rhinitis case-control environment inflammatory biomarkers dietCase-Control StudiesEpidemiologic Research DesignImmunologyHousingdietbusinessEnvironmental Pollutionasthma; allergic rhinitisInternational archives of allergy and immunology
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BODE index or geriatric multidimensional assessment for the prediction of very-long-term mortality in elderly patients with chronic obstructive pulmo…

2013

BACKGROUND a multidimensional approach-the BODE index-has been proposed for prognostic purposes in chronic obstructive pulmonary disease (COPD) and theoretically seems to be well suited for elderly people, but there is a lack of data in this population, especially with respect to long-term survival. The objective of this study is to evaluate whether the BODE index can predict both long (5 years) and very-long (10 and 15 years)-term mortality in an unselected population of elderly people with COPD better than a set of variables commonly taken into account in a geriatric multidimensional assessment (MDA). METHODS : this was a multicentre, prospective, population study. We used data from the S…

MaleBODE indexAgingmedicine.medical_specialtyPhysical disabilityPopulationCohort StudiesPulmonary Disease Chronic ObstructivePredictive Value of TestsInternal medicinemedicineHumansLongitudinal StudiesProspective StudieseducationProspective cohort studyGeriatric AssessmentAgedProportional Hazards ModelsAged 80 and overeducation.field_of_studyCOPDbusiness.industryGeneral Medicinemedicine.diseasehumanitiesRespiratory Function TestsSurvival RateMoodItalyQuartilePhysical therapyPopulation studyFemaleGeriatrics and GerontologybusinessAge and Ageing
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Homozygous disruption of PDZD7 by reciprocal translocation in a consanguineous family: a new member of the Usher syndrome protein interactome causing…

2008

A homozygous reciprocal translocation, 46,XY,t(10;11),t(10;11), was detected in a boy with non-syndromic congenital sensorineural hearing impairment. Both parents and their four other children were heterozygous translocation carriers, 46,XX,t(10;11) and 46,XY,t(10;11), respectively. Fluorescence in situ hybridization of region-specific clones to patient chromosomes was used to localize the breakpoints within bacterial artificial chromosome (BAC) RP11-108L7 on chromosome 10q24.3 and within BAC CTD-2527F12 on chromosome 11q23.3. Junction fragments were cloned by vector ligation and sequenced. The chromosome 10 breakpoint was identified within the PDZ domain containing 7 (PDZD7) gene, disrupti…

MaleCandidate geneHeterozygoteUsher syndromePDZ domainMolecular Sequence DataChromosomal translocationBiologyTranslocation GeneticConsanguinityotorhinolaryngologic diseasesGeneticsmedicineHumansAmino Acid SequenceHearing LossMolecular BiologyGenetics (clinical)GeneticsGene RearrangementBacterial artificial chromosomemedicine.diagnostic_testBase SequenceChromosomes Human Pair 10Chromosomes Human Pair 11BreakpointHomozygoteChromosomeGeneral Medicinemedicine.diseaseMolecular biologyPedigreeChild PreschoolEar InnerFemaleUsher SyndromesFluorescence in situ hybridizationHuman molecular genetics
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Predictors of short‐ and long‐term outcomes of patients undergoing transcatheter mitral valve edge‐to‐edge repair

2020

Objectives Transcatheter mitral valve repair (TMVR) by edge-to-edge therapy is an established treatment for severe mitral valve regurgitation (MR). Background Symptomatic and prognostic benefit in functional MR has been shown recently; nevertheless, data on long-term outcomes are sparse. Methods and results We analyzed survival of patients treated with isolated edge-to-edge repair from June 2010 to March 2018 (primarily combined edge-to-edge repair with other mitral valve interventions was excluded) in a retrospective monocentric study. Overall, 627 consecutive patients (47.0% females, 78.6 years in mean) were included. Leading etiology was functional MR (57.4%). Follow-up regarding surviva…

MaleCardiac Catheterizationmedicine.medical_specialtymedicine.medical_treatmentDischarged alive030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineMitral valveLong term outcomesmedicineHumansRadiology Nuclear Medicine and imaging030212 general & internal medicineRetrospective StudiesHeart Valve Prosthesis ImplantationCOPDMitral valve repairMitral regurgitationbusiness.industryMitral Valve InsufficiencyGeneral Medicinemedicine.diseaseSurgeryTreatment Outcomemedicine.anatomical_structureEtiologyMitral ValveFemaleCardiology and Cardiovascular MedicineMitral valve regurgitationbusinessCatheterization and Cardiovascular Interventions
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