Search results for "PDCA"
showing 2 items of 2 documents
Effects of the MDM2 inhibitor Nutlin-3a on sensitivity of pancreatic cancer cells to berberine and modified berberines in the presence and absence of…
2021
Abstract Approaches to improve pancreatic cancer therapy are essential as this disease has a very bleak outcome. Approximately 80% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). A key regulatory gene frequently mutated (∼75%) in PDAC is the TP53 tumor suppressor gene which controls the transcription of multiple genes involved in cell cycle progression, apoptosis, cancer progression and other growth regulatory processes. The mouse double minute 2 homolog (MDM2) gene product is a nuclear-localized E3 ubiquitin ligase and negatively regulates the TP53 protein which results in its proteasomal degradation. Various MDM2 inhibitors have been isolated and examined in clinical t…
Meat substitutes: formulations and comparative analysis
2021
The nutritional quality of animal products is often overlooked in our consumers' imaginations. Sustainability for example, must takeinto account sustainability for humans, starting with meeting their nutritional needs as naturally as possible. For starters, the protein intake, inquantity per 100 g of edible food (usually cooked), greatly exceeds those of vegan equivalents, whether they are meat analogues made fromvegetable proteins or vegetarian dishes reputed to be sources of protein (chickpeas, hummus, lentils, tofu etc.). In addition, it is clear that animalproducts are protein sources of high nutritional quality (DIAAS 80) unlike vegetarian equivalents (DIAAS 80). Animal proteins ar…