Search results for "PDE"
showing 10 items of 558 documents
On the scientific work of Victor Isakov
2022
Some recent results on singular $ p $-Laplacian systems
2022
Some recent existence, multiplicity, and uniqueness results for singular p-Laplacian systems either in bounded domains or in the whole space are presented, with a special attention to the case of convective reactions. A extensive bibliography is also provided.
Some recent results on a singular p-laplacian equations
2022
Abstract A short account of some recent existence, multiplicity, and uniqueness results for singular p-Laplacian problems either in bounded domains or in the whole space is performed, with a special attention to the case of convective reactions. An extensive bibliography is also provided.
Existence of two solutions for singular Φ-Laplacian problems
2022
AbstractExistence of two solutions to a parametric singular quasi-linear elliptic problem is proved. The equation is driven by theΦ\Phi-Laplacian operator, and the reaction term can be nonmonotone. The main tools employed are the local minimum theorem and the Mountain pass theorem, together with the truncation technique. GlobalC1,τ{C}^{1,\tau }regularity of solutions is also investigated, chiefly viaa prioriestimates and perturbation techniques.
Fragment‐ and Negative Image‐Based Screening of Phosphodiesterase 10A Inhibitors
2019
A novel virtual screening methodology called fragment‐ and negative image‐based (F‐NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A‐specific small‐molecule inhibitors are actively sought after for their antipsychotic and neuroprotective effects. The F‐NiB combines features from both fragment‐based drug discovery and negative image‐based (NIB) screening methodologies to facilitate rational drug discovery. The selected structural parts of protein‐bound ligand(s) are seamlessly combined with the negative image of the target's ligand‐binding cavity. This cavity‐ and fragment‐based hybrid model, namely its shape and electr…
A Sub-Supersolution Approach for Robin Boundary Value Problems with Full Gradient Dependence
2020
The paper investigates a nonlinear elliptic problem with a Robin boundary condition, which exhibits a convection term with full dependence on the solution and its gradient. A sub- supersolution approach is developed for this type of problems. The main result establishes the existence of a solution enclosed in the ordered interval formed by a sub-supersolution. The result is applied to find positive solutions.
Regular solutions for nonlinear elliptic equations, with convective terms, in Orlicz spaces
2022
We establish some existence and regularity results to the Dirichlet problem, for a class of quasilinear elliptic equations involving a partial differential operator, depending on the gradient of the solution. Our results are formulated in the Orlicz-Sobolev spaces and under general growth conditions on the convection term. The sub- and supersolutions method is a key tool in the proof of the existence results.
The Radó–Kneser–Choquet theorem for $p$-harmonic mappings between Riemannian surfaces
2020
In the planar setting the Rad\'o-Kneser-Choquet theorem states that a harmonic map from the unit disk onto a Jordan domain bounded by a convex curve is a diffeomorphism provided that the boundary mapping is a homeomorphism. We prove the injectivity criterion of Rad\'o-Kneser-Choquet for $p$-harmonic mappings between Riemannian surfaces. In our proof of the injecticity criterion we approximate the $p$-harmonic map with auxiliary mappings that solve uniformly elliptic systems. We prove that each auxiliary mapping has a positive Jacobian by a homotopy argument. We keep the maps injective all the way through the homotopy with the help of the minimum principle for a certain subharmonic expressio…
Location of solutions for quasi-linear elliptic equations with general gradient dependence
2017
Existence and location of solutions to a Dirichlet problem driven by $(p,q)$-Laplacian and containing a (convection) term fully depending on the solution and its gradient are established through the method of subsolution-supersolution. Here we substantially improve the growth condition used in preceding works. The abstract theorem is applied to get a new result for existence of positive solutions with a priori estimates.
Numerical Recovery of Source Singularities via the Radiative Transfer Equation with Partial Data
2013
The inverse source problem for the radiative transfer equation is considered, with partial data. Here we demonstrate numerical computation of the normal operator $X_{V}^{*}X_{V}$ where $X_{V}$ is the partial data solution operator to the radiative transfer equation. The numerical scheme is based in part on a forward solver designed by F. Monard and G. Bal. We will see that one can detect quite well the visible singularities of an internal optical source $f$ for generic anisotropic $k$ and $\sigma$, with or without noise added to the accessible data $X_{V}f$. In particular, we use a truncated Neumann series to estimate $X_{V}$ and $X_{V}^{*}$, which provides a good approximation of $X_{V}^{*…