Search results for "PECTIN"

showing 10 items of 162 documents

The Anemonia viridis Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research

2018

Blue biotechnologies implement marine bio-resources for addressing practical concerns. The isolation of biologically active molecules from marine animals is one of the main ways this field develops. Strikingly, cnidaria are considered as sustainable resources for this purpose, as they possess unique cells for attack and protection, producing an articulated cocktail of bioactive substances. The Mediterranean sea anemone Anemonia viridis has been studied extensively for years. In this short review, we summarize advances in bioprospecting of the A. viridis toxin arsenal. A. viridis RNA datasets and toxin data mining approaches are briefly described. Analysis reveals the major pool of neurotoxi…

0301 basic medicineNeurotoxinsPharmaceutical ScienceRNA-SeqVenomReviewComputational biologyCnidarian VenomAnemoniaTranslational Research Biomedicaltranscriptomics03 medical and health sciencescomputational biologyCnidarian VenomsDrug DiscoveryAnimalsData MiningMarine ToxinTranslational Medical Researchlcsh:QH301-705.5Pharmacology Toxicology and Pharmaceutics (miscellaneous)Sea AnemoneBioprospectingbiologyAnimalSequence Analysis RNASustainable resourcesDrug Discovery3003 Pharmaceutical ScienceRNAAnemonebio-prospectingbiology.organism_classificationSea Anemones030104 developmental biologyTranscriptomiclcsh:Biology (General)RNAMarine ToxinsNeurotoxinMarine toxinMarine Drugs
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Leaf and Root Extracts from Campomanesia adamantium (Myrtaceae) Promote Apoptotic Death of Leukemic Cells via Activation of Intracellular Calcium and…

2017

Phytochemical studies are seeking new alternatives to prevent or treat cancer, including different types of leukemias. Campomanesia adamantium, commonly known as guavira or guabiroba, exhibits pharmacological properties including antioxidant, antimicrobial, and antiproliferative activities. Considering the anticancer potential of this plant species, the aim of this study was to evaluate the antileukemic activity and the chemical composition of aqueous extracts from the leaves (AECL) and roots (AECR) of C. adamantium and their possible mechanisms of action. The extracts were analyzed by LC-DAD-MS, and their constituents were identified based on the UV, MS, and MS/MS data. The AECL and AECR s…

0301 basic medicineProgrammed cell deathnatural productsbioprospectingCaspase 3PharmacologyJurkat cellsCalcium in biology03 medical and health scienceschemistry.chemical_compound0302 clinical medicinemedicinal plantcancerPharmacology (medical)Propidium iodideCytotoxicityCaspasePharmacologybiologylcsh:RM1-950LC-MSlcsh:Therapeutics. Pharmacology030104 developmental biologychemistryBiochemistryApoptosis030220 oncology & carcinogenesisbiology.proteinFrontiers in Pharmacology
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Biopiracy of natural products and good bioprospecting practice

2016

Made available in DSpace on 2018-11-26T16:27:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-02-15 Deutsche Forschungsgemeinschaft Background: Biopiracy mainly focuses on the use of biological resources and/or knowledge of indigenous tribes or communities without allowing them to share the revenues generated out of economic exploitation or other non-monetary incentives associated with the resource/knowledge. Methods: Based on collaborations of scientists from five continents, we have created a communication platform to discuss not only scientific topics, but also more general issues with social relevance. This platform was termed 'PhytCancer -Phytotherapy to Fight Cancer' (www.phy…

0301 basic medicineResource (biology)Drug IndustryInternational CooperationTheftPharmaceutical ScienceIntellectual property0603 philosophy ethics and religionIndigenousPatents as Topic03 medical and health sciencesIndigenous knowledgeDrug DiscoveryPatents as TopicTraditional knowledgeDeveloping CountriesPharmacologyBioprospectingBiological ProductsBioprospectingPlants Medicinalbusiness.industryIntellectual propertyCommercializationOwnership06 humanities and the artsPublic relationsBioethicsNatural resource030104 developmental biologyIncentiveComplementary and alternative medicineEthnopharmacologyMolecular MedicinePatent060301 applied ethicsBusiness
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The essentials of marine biotechnology

2021

Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well as tried to support new economic endeavors (ocean energy, desalination for water supply, and seabed mining). Modern societies and lifestyle resulted in an increased demand for dietary diversity, better health and well-being, new biomedicines, natural cosmeceuticals, environmental conservation, and sustainable energy sources. These societal needs stimulated the interest of researchers on the diverse and underexplored marine environments as promising and sustainable sources of biomolecules and biomass, and they are addressed by the emerging field of ma…

0301 basic medicine[SDV.BIO]Life Sciences [q-bio]/Biotechnologylcsh:QH1-199.5Stakeholder engagementOceanographyResponsible research and innovation (RRI)challangesNatural-productsResponsible research and innovation0302 clinical medicineMarine bioeconomyIn-silico predictionlcsh:SciencevalorizationMarine biodiversityWater Science and TechnologybiodiversityHeavy-metal detoxificationBioprospectingGlobal and Planetary ChangeBioprospectingLead-like moleculesconservationBiological SciencesSustainabilityMarine natural products[SDE]Environmental SciencesSolid-phase microextractionDeep-sea sedimentsNatural Sciencesmarine biotechnologymarine bioeconomyMarine conservationmarine biotechnology valorization biodiversity conservation challangesOcean EngineeringAquatic Sciencelcsh:General. Including nature conservation geographical distributionBioactive compoundsBlue growthWaste-water treatment03 medical and health sciencesbioprospecting ; blue growth ; marine biodiversity ; marine natural products ; sustainability ; ethics ; responsible research and innovation (RRI) ; marine bioeconomy14. Life underwaterRecreation[SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/OceanographyEthicsResponsible Research and Innovationbusiness.industrySecondary metabolitesParticulate organic-carbonBiotechnology030104 developmental biology13. Climate actionAgricultureSustainabilitymarine biotechnology ; Blue growth ; Marine Biodiversity ; marine natural product ; sustainability ; Ethics ; Responsible research & innovationlcsh:Qbusiness030217 neurology & neurosurgeryTourism
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Invasion of Finnish inland waters by the alien moss animal Pectinatella magnifica Leidy, 1851 and associated potential risks

2018

Introduced alien species bring potential adverse impacts on biodiversity and ecosystem functions. International shipping is an important vector for such unintentional introductions in aquatic environments. Therefore, in addition to climate change and eutrophication, increasing international shipping may enhance the spread of alien species into areas which have not previously been considered prone to alien invasions. One example of such development might be the recent invasion of the moss animal Pectinatella magnifica into Finnish inland waters, which are generally considered to be hostile to alien species. We took advantage of observations made by the general public and recorded by environm…

0301 basic medicineinland watersEcologybiologyEcologyta1172vesiekosysteemitAlienManagement Monitoring Policy and Lawbiology.organism_classificationsisävedetPectinatella magnificaBryozoaintroduced species03 medical and health sciences030104 developmental biologysammaleläimetSuomiBryozoata1181vieraslajitEcology Evolution Behavior and SystematicsFinlandaquatic ecosystemsManagement of Biological Invasions
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Intranasal fentanyl versus fentanyl pectin nasal spray for the management of breakthrough cancer pain in doses proportional to basal opioid regimen.

2014

Abstract The aim of this randomized, crossover, comparison study was to assess the analgesic and adverse effects of 2 nasal preparations, intranasal fentanyl (INFS) and fentanyl pectin nasal spray (FPNS), for breakthrough pain, given in doses proportional to opioid basal regimen. Each patient randomly received INFS or FPNS in doses proportional to opioid dosages used for background analgesia for 2 pairs of episodes. For each episode of breakthrough pain, pain intensity and adverse effects intensity were recorded just before starting the INFS or FPNS (T0) and 5 minutes (T5), 10 minutes (T10), and 20 minutes (T20) after the administration of the nasal drugs. Sixty-nine patients were studied. …

AdultMalefentanyl pectin nasal spraymedicine.medical_treatmentAnalgesicSettore MED/42 - Igiene Generale E ApplicataFentanylrapid-onset opioidsNeoplasmsparasitic diseasesMedicineHumansCancer painAdverse effectAgedPain MeasurementAged 80 and overDose-Response Relationship Drugbusiness.industryBreakthrough Painintranasal fentanylNasal SpraysMiddle AgedCancer pain; breakthrough pain; fentanyl pectin nasal spray; intranasal fentanyl; rapid-onset opioidsAnalgesics OpioidFentanylRegimenAnesthesiology and Pain MedicineCross-Sectional StudiesNeurologyOpioidNasal sprayAnesthesiaPectinsNasal administrationFemaleNeurology (clinical)businessCancer painmedicine.drugThe journal of pain
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Comparison of topical tacrolimus 0.1 % in pectin ointment with clobetasol 0.5% ointment in adults with moderate to severe desquamative gingivitis: A …

2006

BACKGROUND: Desquamative gingivitis (DG) is a clinical condition characterized by red, painful, glazed, and friable gingiva, which might be a manifestation of some autoimmune mucocutaneous diseases. The time from the development of initial signs of DG to diagnosis can vary from months to years. Based on a literature search, no data concerning patients with DG without signs of autoimmune disease were available. OBJECTIVE: The aim of this trial was to compare the efficacy and tolerability of monotherapy with topical tacrolimus 0.1% in pectin ointment versus clobetasol propionate 0.5% ointment in adults affected by DG. METHODS: This randomized, double-blind clinical trial was conducted at the …

AdultMalemedicine.medical_specialtySettore MED/09 - Medicina InternaErythemaAdministration TopicalPopulationSeverity of Illness IndexTacrolimuslaw.inventionOintmentsRandomized controlled trialDouble-Blind Methodlawdesquamative gingivitimedicineClinical endpointHumansPharmacology (medical)educationAgedPharmacologyeducation.field_of_studyDose-Response Relationship Drugbusiness.industryMiddle Agedmedicine.diseaseDermatologyGingivitisdesquamative gingivitisTacrolimusSurgeryDesquamative gingivitisTreatment OutcomeTolerabilityclobetasoltopical tacrolimus; clobetasol; desquamative gingivitis; randomized double-blind clinical trialtacrolimus clobetasol desquamative gingivitisPectinsDrug Therapy CombinationFemaleClobetasol propionatemedicine.symptombusinessImmunosuppressive Agentsmedicine.drugFollow-Up Studiestopical tacrolimurandomized double-blind clinical trial
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Survival of immediately versus delayed loaded short implants: a prospective case series study

2015

Background: To assess and compare survival rates of immediately and delayed loaded short implants (7 mm) in free ends of a partially edentulous jaw with moderate-severe alveolar bone resorption. Material and Methods: 24 patients with atrophic edentulous free-ends were included in this prospective study. Four study groups were monitored monthly and their behavior was evaluated: bridges supported only by short implants and mixed short and long implant bridge groups, both with immediate and delayed loading. Failures, bone loss, probing depth and bleeding on probing were evaluated. Results: 54 Mk III Shorty TiU and 15 Brånemark System®MK III TiU implants with a length longer than 7mm were inclu…

AdultMalemedicine.medical_specialtyTime Factorsmedicine.medical_treatmentBleeding on probingDentistryOdontologíaBone resorptionDental Prosthesis RetentionmedicineHumansJaw EdentulousProspective StudiesProspective cohort studyBridge (dentistry)General DentistrySurvival rateProspeccióDental alveolusAgedDental ImplantsImplants dentalsbusiness.industryResearchDental implantsMiddle Aged:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludResorptionSurgeryDental Prosthesis DesignOtorhinolaryngologyEstudi de casosUNESCO::CIENCIAS MÉDICASFemaleSurgeryImplantCase studiesOral Surgerymedicine.symptombusinessProspecting
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Sustainable bioactive pectin-based films to improve fruit safety via a circular economy approach.

2023

This work reports on the valorisation of persimmon (Diospyros kaki Thunb.) for the development of food-grade antiviral coatings against major viral foodborne pathogens, human noroviruses (NoVs) and hepatitis A virus (HAV). Initially, the antiviral activity of polyphenol-rich pectin extracts with abundant non-covalent interactions (PPN), pectin extracts enriched with intact pectin-polyphenol ester and O-glycosyl bonds (PPC) and hydro-ethanolic polyphenol-rich extracts (EPE) was compared. Higher viral reductions were found for the pectin extracts rich in polyphenols, mainly in those containing covalent pectin-polyphenol interactions. This specific extract was mixed with commercial citrus pect…

Antiviral coatingsEdible filmsFruitaPersimmonGeneral Chemical EngineeringMicroorganismes patògensGeneral ChemistryPectin-polyphenol complexesControl de qualitatFood Science
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Glucose and Ethanol Tolerant Enzymes Produced by Pichia (Wickerhamomyces) Isolates from Enological Ecosystems

2012

A total of 17 Pichia ( Wickerhamomyces ) isolates obtained from enological ecosystems in the Utiel-Requena Spanish region were characterized by physiological (using API 20C AUX strips and ID Yeast Plus System miniaturized identification systems) and molecular (PCR-RFLP and sequencing) techniques as belonging to the species P. fermentans, P. membranifaciens , and W. anomalus . Data support the reclassification of P. anomala as Wickerhamomyces anomalus . In order to characterize their enzymatic abilities, xylanase, β-glucosidase, lipase, esterase, protease, and pectinase qualitative and quantitative assays were made. Wickerhamomyces anomalus and P. membranifaciens were the most interesting sp…

BiochemistryWickerhamomycesWickerhamomyces anomalusXylanaseGlycoside hydrolaseHorticultureBiologyPectinasebiology.organism_classificationEsteraseYeastFood SciencePichiaAmerican Journal of Enology and Viticulture
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