Search results for "PELE"

showing 10 items of 139 documents

Characterization of patients with mood disorders for their prevalent temperament and level of hopelessness.

2014

Abstract Background Mood disorders (MD) are disabling conditions throughout the world associated with significant psychosocial impairment. Affective temperaments, as well as hopelessness, may play a significant role in the pathophysiology of MD. The present study was designed to characterize patients with MD for their prevalent affective temperament and level of hopelessness. Methods Five hundred fifty-nine (253 men and 306 women) consecutive adult inpatients were assessed using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire version (TEMPS-A), the Gotland Scale for Male Depression (GSMD), the Beck Hopelessness Scale (BHS) and the Mini International Neurop…

AdultMalemedicine.medical_specialtyHyperthymic temperamentBipolar Disordermedia_common.quotation_subjectpsychologyHopemedicineHumansBipolar disorderTemperamentPsychiatryAgedMini-international neuropsychiatric interviewmedia_commonDepressive DisorderDepressive Disorder MajorAdult Aged Anxiety Disorders; psychology Bipolar Disorder; psychology Cross-Sectional Studies Cyclothymic Disorder; psychology Depressive Disorder; Major; psychology Female Hope Humans Irritable Mood Male Middle Aged TemperamentMajorMiddle Agedmedicine.diseaseAnxiety DisordersCyclothymic DisorderIrritable MoodPsychiatry and Mental healthClinical PsychologyCross-Sectional StudiesMood disordersBeck Hopelessness ScaleMajor depressive disorderAnxietyFemaleTemperamentmedicine.symptomPsychologyClinical psychology
researchProduct

Geoconservation in Sicily (Italy): the Example of the Isola delle Femmine (Palermo)

2022

Abstract The Regional Administration of Sicily recently erected Isola delle Femmine—a small island of the Tyrrhenian Sea, close to Palermo—as a geosite. A detailed geological survey has been carried out in order to define the most important geological features of the island together with the development of a new geological map based on topographic data and a digital model at 1:2.000 scale specially processed. Finally, a geological pathway through the island has been traced and illustrated. The geological substrate of Isola delle Femmine consists of a Mesozoic carbonate succession belonging to the Panormide Carbonate Platform. Two lithostratigraphic units have been differentiated. The lowest…

Geosites · Geological map · Carbonates · Speleothems · Cretaceous · SicilyCarbonates; Cretaceous; Geological map; Geosites; Sicily; Speleothems;Geography Planning and DevelopmentEarth and Planetary Sciences (miscellaneous)CarbonatesGeological mapSettore GEO/02 - Geologia Stratigrafica e SedimentologicaGeositesSicilyCretaceousNature and Landscape ConservationSpeleothems
researchProduct

Sensorimotoro funkciju novērtēšana cilindra un stūra testā pelēm pēc modelēta insulta

2021

Insults ir akūta neiroloģiska disfunkcija, kas izraisa neiroloģiskas, sensorimotoras un uzvedības izmaiņas. Lai izprastu insulta patoloģiskos mehānismus un izstrādātu jaunas terapijas, insults tiek modelēts eksperimentāli. Stūra un cilindra uzvedības testus izmanto, lai novērtētu sensorimotorās funkcijas grauzējiem. Maģistra darba mērķis ir izvērtēt cilindra un stūra testa pielietojumu modelēta insulta gadījumā pelēm divu mēnešu periodā. Pētījumā secināts - lai mazinātu peļu pierašanu un neaktivitāti, cilindra un stūra testus ieteicams veikt pārmaiņus, kā arī ne pārāk bieži. Pētījuma sākumā ieteicams veikt pirms operācijas griešanās preferences novērtēšanu. Precīzākai novērtēšanai ieteicams…

stūra testssensorimotorie traucējumiFarmācijainsultspelescilindra tests
researchProduct

Late Quaternary Variations in the South American Monsoon System as Inferred by Speleothems – New Perspectives Using the SISAL Database

2018

Here we present an overview of speleothem δ18O records from South America, most of which are available in the Speleothem Isotopes Synthesis and Analysis (SISAL_v1) database. South American tropical and subtropical speleothem δ18O time series are primarily interpreted to reflect changes in precipitation amount, the amount effect, and consequently history of convection intensity variability of convergence zones such as the Intertropical Convergence Zone (ITCZ) and the South America Monsoon System (SAMS). We investigate past hydroclimate scenarios in South America related to the South American Monsoon System in three different time periods: Late Pleistocene, Holocene, and the last two millenni…

geographygeography.geographical_feature_categoryDatabaseIntertropical Convergence ZoneSpeleothemSubtropicscomputer.software_genreMonsoonatmospheric_sciencePrecipitationSouth Atlantic Convergence ZoneQuaternarycomputerHoloceneGeology
researchProduct

Quality of Life and Job Loss during the COVID-19 Pandemic: Mediation by Hopelessness and Moderation by Trait Emotional Intelligence

2022

This study contributes to the knowledge on the effects of the COVID-19 pandemic by examining a moderated mediation model in which the impact of job loss over quality of life (QoL) is mediated by hopelessness and moderated by trait emotional intelligence (trait EI). Data were collected from a large nationally representative Italian sample of adult workers (N = 1610), who completed a series of anonymous online questionnaires. Total, direct and indirect effects were estimated through bootstrapped mediated moderation analyses providing 95% bias corrected bootstrap confidence intervals. After controlling for the effects of gender and age range, job loss was found to be negatively associated with…

BHSAdultJob lossSARS-CoV-2Health Toxicology and MutagenesisPublic Health Environmental and Occupational HealthCOVID-19 pandemicCOVID-19job lohumanitiesTEIQueWHOQOLhopelessnetrait emotional intelligenceQuality of LifeHopelessnessHumansPandemicsCOVID-19 pandemic; quality of life; trait emotional intelligence; hopelessness; job loss; TEIQue; WHOQOL; BHSEmotional IntelligenceInternational Journal of Environmental Research and Public Health
researchProduct

Isotope disequilibrium effects: The influence of evaporation and ventilation effects on the carbon and oxygen isotope composition of speleothems – A …

2012

Abstract In order to improve the understanding of variations of speleothem δ18O and δ13C values in the context of palaeoclimate research, it is important to quantify the isotope fractionation processes influencing the δ18O and δ13C values of stalagmites. Here we present an extended version of speleothem stable isotope model that accounts for evaporation and condensation effects during precipitation of calcite. The ISOLUTION-model allows to calculate the effect of evaporation on δ18Ocalcite and δ13Ccalcite values in dependence on relative humidity and wind velocity. Our results reveal that evaporation may have a significant effect on δ18Ocalcite and δ13Ccalcite due to the loss of H2O from th…

Hydrologygeographygeography.geographical_feature_categoryδ18OStable isotope ratioEvaporationSpeleothemContext (language use)Atmospheric sciencesIsotopes of oxygenIsotope fractionationGeochemistry and PetrologyRelative humidityGeologyGeochimica et Cosmochimica Acta
researchProduct

2021

Holocene climate in Central Europe was characterized by variations on millennial to decadal time scales. Speleothems provide the opportunity to study such palaeoclimate variability using high temporal resolution proxy records, and offer precise age models by U-series dating. However, the significance of proxy records from an individual speleothem is still a matter of debate, and limited sample availability often hampers the possibility to reproduce proxy records or to resolve spatial climate patterns. Here we present a palaeoclimate record based on four stalagmites from the Hüttenbläserschachthöhle (HBSH), western Germany. Two specimens cover almost the entire Holocene, with a short hiatus …

geographygeography.geographical_feature_category010504 meteorology & atmospheric sciencesδ18OStable isotope ratioSpeleothemStalagmite010502 geochemistry & geophysics01 natural sciencesProxy (climate)Isotope fractionationCave13. Climate actionGeneral Earth and Planetary SciencesPhysical geographyGeologyHolocene0105 earth and related environmental sciencesFrontiers in Earth Science
researchProduct

Myytistä yksilöksi, haukasta ihmiseksi : neuvostosankarimyytin purkaminen Viktor Pelevinin teoksessa Omon Ra

2006

Pelevin Viktorsosialistinen realismimyytitOmon RaparodiaNeuvostoliittosatiirisankaruus
researchProduct

Influence of the Plio-Pleistocene tectonics on the evolution of the Purgatorio polje (north-western Sicily)

2013

The evolution of large landforms such as polje are related in most cases to geological events affecting a specific areal context and/or to climatic events which, in combination with the tectonics, affect the karst base level, in a more or less pronounced manner depending on the proximity of limestone karst mountains to the coastline. The genesis of these aforementioned forms depends primarily on structural and lithological factors, their evolution is instead controlled by tectonic and climaticeustatic factors in the reliefs close to the coast. In the inland, due to the distance from the coast, the effects of the latter factors on the karstification process could be less, or very bland, in r…

SpeleogenesitectonicPlio-Pleistocene
researchProduct

Conformational response to ligand binding in phosphomannomutase2: insights into inborn glycosylation disorder.

2014

Background: Mutations in phosphomannomutase2 cause glycosylation disorder, a disease without a cure that will largely benefit from accurate ligand-bound models. Results: We obtained two models of phospomannomutase2 bound to glucose 1,6-bisphosphate and validated them with limited proteolysis. Conclusion: Ligand binding induces a large conformational transition in PMM2. Significance: We produce and validate closed-form models of PMM2 that represent a starting point for rational drug discovery.

Models MolecularPELEGlycosylationProtein Conformation1Molecular Sequence DataGlucose-6-PhosphateGlycosylation Inhibitor6-bisphosphate; PELE; computer modeling; drug discovery; glycosylation; glycosylation inhibitor; ligand-binding protein; phosphomannomutaseLigandsDrug DiscoveryAnimalsHumansAmino Acid Sequence16-BisphosphateProtein UnfoldingTemperatureLigand-binding Proteinphosphomannomutase 2 and mass spectrometryPhosphotransferases (Phosphomutases)PhosphomannomutaseMutationProteolysisMetabolism Inborn ErrorsMolecular BiophysicsPeptide HydrolasesProtein BindingComputer ModelingThe Journal of biological chemistry
researchProduct