Search results for "PEOPLE"

Genotype and Allele Frequencies of Drug-Metabolizing Enzymes and Drug Transporter Genes Affecting Immunosuppressants in the Spanish White Population

2013

Interpatient variability in drug response can be widely explained by genetically determined differences in metabolizing enzymes, drug transporters, and drug targets, leading to different pharmacokinetic and/or pharmacodynamic behaviors of drugs. Genetic variations affect or do not affect drug responses depending on their influence on protein activity and the relevance of such proteins in the pathway of the drug. Also, the frequency of such genetic variations differs among populations, so the clinical relevance of a specific variation is not the same in all of them. In this study, a panel of 33 single nucleotide polymorphisms in 14 different genes (ABCB1, ABCC2, ABCG2, CYP2B6, CYP2C19, CYP2C…

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.

2014

Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of CASP8 in breast cancer susceptibility, we carried out dense genotyping of this region in the Breast Cancer Association Consortium (BCAC). Single-nucleotide polymorphisms (SNPs) spanning a 1 Mb region around CASP8 were genotyped in 46 450 breast cancer cases and 42 600 controls of European origin from 41 studies participating in the BCAC as part of a custom genotyping array experiment (iCOGS). Missing genotypes and SNPs were imputed and, after quality exclusions, 501 typed and 1232 imputed SNPs were included in logistic regressionmodels adjusting for stud…

Consequences of Sarcopenia in Older People: The Epidemiological Evidence

2021

Sarcopenia is a common condition in older people. Increasing literature is showing its importance for negative health outcomes, also beyond the perimeter of geriatric medicine. In this chapter, we will discuss the consequences of sarcopenia. Overall, epidemiological research suggests that sarcopenia is significantly associated with falls and fractures also suggesting a strong association between muscle and bone loss conditions, as in the case of osteosarcopenia. Moreover, sarcopenia is associated with disability, hospitalization (particularly in older people already hospitalized), and finally mortality. Increasing research is also showing that sarcopenia is associated with negative outcomes…

Interaction between clients and physiotherapists in group exercise classes in geriatric rehabilitation

2009

The aim of this paper is to explore how older people construct their interaction in group exercise classes in geriatric rehabilitation and what is their contribution to the interaction. Discourse analysis was employed and data, consisting of seven videotaped group-based exercise sessions, were collected from 52 older people (aged 66–93 years) and nine rehabilitation professionals in seven rehabilitation centres. Four discourse categories were found. In “taciturn exercising”, older people remained verbally silent but physically active. In “submissive disagreeing”, older people opposed the professionals’ agenda by displaying reluctant consent to proposals. In “resilient endeavouring”, older a…

Validation of the University of California, Los Angeles Loneliness Scale (version 3) in Spanish older population: An application of exploratory struc…

2020

Loneliness is a subjective and unpleasant experience associated to a variety of physical and mental health problems. Older people face an elevated risk of loneliness. It is measured through self‐re...

ROAD NETWORK HILLINESS AND DEVELOPMENT OF WALKING DIFFICULTIES AMONG COMMUNITY-DWELLING OLDER PEOPLE

2017

Aims: To study associations between objective road network hilliness and development of walking difficulties (WD) within two years, and to examine how hilliness as a perceived barrier and frequency of moving through the neighborhood affect to this.

Kotona asuvan muistisairaan henkilön ja hänen läheistensä teknologiaan liittyvät tarpeet ja toiveet

2018

Tutkimuksessa selvitettiin millaisia tarpeita ja toiveita kotona asuvilla muistisairailla ja heidän läheisillään on kotona asumista tukevaan teknologiaan liittyen. Tutkimukseen osallistui 25 kotona asuvaa muistisairasta henkilöä ja 25 heidän läheistään. Metodina käytettiin etnografista tutkimusotetta. Aineistonkeruumenetelminäolivat avoin haastattelua ja havainnointi. Analyysimenetelmänä käytettiin sisällön analyysiä. Tarpeet ja toiveet voitiin luokitella kolmeen pääluokkaan, jotka olivat itsemääräämisoikeuden säilyminen, sosiaalisten suhteiden säilyminen ja liikkumisen oikeus ja turvallisuus. Haasteita olivat yksinäisyyden kokemus, muistin ja toimintakyvyn heikkenemiseen liittyvät ongelmat…

Trends in HIV sexual prevention: Attitudinal beliefs and behavioral intention in Spanish young people over the past two decades (1999-2020).

2022

Abstract Despite preventive efforts, HIV exposure is still a concern for public health. The current prevalence is related to unsafe sex, which is based on socio-cognitive variables. Therefore, information about these variables is required to verify whether the past preventive strategies have been effective and improve the future ones. However, there is not updated information to adjust future preventive interventions. For this reason, this study analyzes trends by gender in Spanish young people over the past two decades in perceived susceptibility to HIV, severity perceived to HIV, condom confidence and the intention of condom use, from 1999 to 2020. For this purpose, 11,665 Spanish young p…

PoliFIT-INFOcus: A pilot study exploring how to promote physical activity in older people.

2018

Effects of an adapted physical activity program on psychophysical health in elderly women.

2016

Giuseppe Battaglia,1,2 Marianna Bellafiore,1,2 Marianna Alesi,1,2 Antonio Paoli,3 Antonino Bianco,1,2 Antonio Palma1,2 1Department of Psychological, Pedagogical and Educational Sciences, 2Sport and Exercise Sciences Research Unit, University of Palermo, Palermo, 3Department of Biomedical Sciences, University of Padova, Padua, Italy Background: Several studies have shown the positive effects of adapted physical activity (APA) on physical and mental health (MH) during the lifetime. The aim of this study was to assess the effectiveness of a specific APA intervention program in the improvement of the health-related quality of life (QOL) and functional condition of spine in elderly women. Method…