Search results for "PERMEABILITY"

Characterization of gas flow through low-permeability claystone: laboratory experiments and two-phase flow analyses

2014

For the characterization of gas migration through a low-permeability clay host rock for deep underground repositories, a comprehensive understanding of the relevant phenomena of gas and fluid flow through low-permeability clay is required. The National Cooperative for the Disposal of Radioactive Waste (Nagra) in Switzerland has developed a comprehensive programme to characterize gas flow in low-permeability Opalinus Clay through laboratory tests and detailed numerical analyses for developing appropriate constitutive models. Laboratory tests were performed on cores by two different laboratories, the Laboratory for Soil Mechanics at EPFL and the Department of Geotechnical Engineering and Geos…

Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Mode…

2018

The enhanced permeability and retention (EPR) effect is the only described mechanism enabling nanoparticles (NPs) flowing in blood to reach tumors by a passive targeting mechanism. Here, using the transparent zebrafish model infected with Mycobacterium marinum we show that an EPR-like process also occurs allowing different types of NPs to extravasate from the vasculature to reach granulomas that assemble during tuberculosis (TB) infection. PEGylated liposomes and other NP types cross endothelial barriers near infection sites within minutes after injection and accumulate close to granulomas. Although similar to 100 and 190 nm NPs concentrated most in granulomas, even similar to 700 nm liposo…

Barrier properties of chitosan coated polyethylene

2012

The transfer properties of chitosan coated polyethylene (PE) films were studied. The barrier properties of non coated PE were not affected by relative humidity changes. The presence of the hydrophilic chitosan layer acted as a water reservoir on the polyethylene film surface which significantly promoted its sensitivity to the water vapour. The water vapour permeability increased 1.85 times at a higher RH. Coated PE films showed more than two-order decrease in the oxygen permeability (PO2) and three-order-decrease in the carbon dioxide permeability (PCO2). When the chitosan coated PE surface was exposed to the water vapour, the PO2 and the PCO2 were significantly increased. However, the perm…

Clustering-triggered endocytic pathway of α2β1 integrin

2012

A discourse on human hair fibers and reflections on the conservation of drug molecules

1996

A gross discourse on human hair fibers and their formation is presented stressing the various interdisciplinary aspects, such as the morphological, biological, structural and biochemical data considered to be important in the field of hair analysis. An attempt is made to explain the incorporation of drug molecules during hair fiber formation by using the classical concepts of drug absorption based on lipoid theory and the pH-partition hypothesis as well as a modern biological approach on the permeability of cell membranes. In addition to the physiochemical considerations of the transport properties of a particular drug molecule such as a) the lipophilicity, which determines permeability thr…

A Study of Osmosis Rate Through Several Proton Conducting Polymer Composite Membranes

2021

Carbon dioxide is typically considered to be a byproduct of various industrial processes that should not be released into the environment due to its nature as a harmful greenhouse gas. One of the more promising ways to dispose of it in an economical and environmentally friendly way is by using it as a raw material in electrochemical synthesis reactors. An important part of such reactors is an ion exchange membrane. In this study the influence of ZrO2 content in SPEEK – ZrO2 composite membranes on rate of osmosis trough them was investigated, with the goal of evaluating ZrO2 as an additive for making ion exchange membranes with fine-tuned osmotic permeability.

Effect of Oxidized Potato Starch on the Physicochemical Properties of Soy Protein Isolate-Based Edible Films

2013

The influence of oxidized starch on the physicochemical properties of cast soy protein isolate films is determined in this study. Films were cast from heated (70 °C for 20 min) alkaline (pH=10) aqueous solutions of 7 % soy protein isolate containing 50 % (by mass) glycerol as a plasticizer and different levels of added oxidized starch (0, 5, 10, 15, and 20 %, by mass). For all types of films, opacity, contact angle, tensile strength, elongation at break, water vapour permeability, measured at 25 °C for four relative humidity differentials (30–53, 30–75, 30–84 and 30–100 %), differential scanning calorimetry and microstructure were determined after conditioning film specimens at 25 °C and 30…

BEST-2K Method for Characterizing Dual-Permeability Unsaturated Soils with Ponded and Tension Infiltrometers

2019

This study presents a new method (BEST-2K) that extends the existing BEST methods for use in characterizing the water retention and hydraulic conductivity functions of matrix and fast-flow regions in dual-permeability soils. BEST-2K requires input information from two water infiltration experiments that are performed under ponded (Beerkan) and unsaturated (tension infiltrometer) conditions at the surface. Other required inputs include water content measurements and the traditional BEST inputs (particle size distribution and bulk density). In this study, first, a flowchart of the BEST-2K method was developed and illustrated with analytically generated data for a synthetic dual-permeability s…

Hydro-mechanical behaviour of a sandy silt from a river embankment

2020

The paper presents the results of an experimental campaign aimed at characterizing the hydro-mechanical behaviour of a sandy silt from a river embankment. Due to continuous river level fluctuations and changing climatic and environmental conditions, flood embankment materials experience frequent variations in degree of saturation and suction values. Such variations strongly impact the earthwork performance both in terms of seepage and stability conditions. For these reasons, a detailed characterization of the material behaviour in unsaturated conditions was carried out. Experiments were designed in order to highlight the response of the involved soil in terms of changes in matric suction an…

Lipodepsipeptides from Pseudomonas syringae are partially proteolyzed and are not absorbed by humans: An in vitro study

2008

There are some concerns about the use of Pseudomonas-based products as biocontrol agents because of the hemolytic activity shown by their metabolites. The effects of Pseudomonas lipodepsipeptides (LDPs) on mammals via ingestion and the LDP degradation during the digestion and intestinal permeability have not been evaluated. In this research, the susceptibility of different LDPs to degradation was assayed with enzymatic gastrointestinal digestion, and intestinal permeability to LDPs was investigated in an in vitro system based on an intestinal cell layer system. Results demonstrated that trypsin and chymotrypsin hydrolyze up to 50% of the various LDPs, and that proteolysis was further increa…