Search results for "PERSISTENT"

Efecto de la duloxetina sobre la expresión de fos en el tronco del encéfalo y en la médula espinal de la rata en modelos de dolor persistente

2015

A pesar de los ensayos clínicos en humanos que avalan el uso clínico de la duloxetina en dolor neuropático, todavía no se conoce en profundidad el sustrato anatómico en el que subyace el efecto analgésico de este antidepresivo. Nuestra revisión bibliográfica sobre el tema no ha ofrecido ni un solo trabajo en el que se pretenda identificar las estructuras neurales supraespinales que se activan o al menos se ven alteradas tras la administración de duloxetina en animales sanos, o con diferentes tipos de dolor neuropático. Parece, sin embargo, que la identificación de los centros troncoencefálicos que ven alterada su actividad neuronal por la administración de estas sustancias, sería de gran ut…

Identificación de los mecanismos epigenéticos relacionados con los fenómenos de inmunosupresión en sepsis y su uso como biomarcadores de pronóstico

2023

La sepsis es un síndrome complejo que provoca una respuesta inmunitaria exacerbada como resultado a una infección, lo que puede causar disfunción orgánica y, en última instancia, la muerte. La sepsis puede avanzar a shock séptico (SS), caracterizado por una disfunción orgánica aguda que puede provocar una insuficiencia circulatoria y metabólica grave, aumentando el riesgo de mortalidad. Los pacientes con sepsis o SS ingresados durante al menos 7 días en la Unidad de Cuidados Intensivos (UCI) que presentan disfunción orgánica y necesidad de ventilación mecánica se clasifican como enfermos críticos crónicos (ECC), los cuales, si están ingresados al menos 14 días y cumplen una serie de caracte…

Novel Perspectives in the Detection of Oral and Nasal Oxidative Stress and Inflammation in Pediatric United Airway Diseases

2010

United airway disease (UAD) concept proposed that asthma and rhinitis are both different clinical manifestation of a single inflammatory process. The aim of this study is to assess in upper and lower airways the level of inflammation and oxidative stress and to investigate the relationship between biomarkers in persistent allergic rhinitis (PER) and in concomitant asthma with PER. By a crosssectional study we measured oral and nasal (FENO) and oral and nasal EBC 8-isoprostane, LTB4 and PGE2 in children with PER (n=14) and with PER and concomitant intermittent asthma (IA; n=25), mild persistent asthma (mA; n=28), moderate persistent asthma (MA; n=13) and in Healthy Controls (HCs; n=13). Oral…

Hepatitis C Virus positive patients with persistently normal serum transaminase: a long-term follow-up

2010

Aqueous-phase reactive species formed by fine particulate matter from remote forests and polluted urban air

2021

In the aqueous phase, fine particulate matter can form reactive species (RS) that influence the aging, properties, and health effects of atmospheric aerosols. In this study, we explore the RS yields of aerosol samples from a remote forest (Hyytiälä, Finland) and polluted urban locations (Mainz, Germany; Beijing, China), and we relate the RS yields to different chemical constituents and reaction mechanisms. Ultra-high-resolution mass spectrometry was used to characterize organic aerosol composition, electron paramagnetic resonance (EPR) spectroscopy with a spin-trapping technique was applied to determine the concentrations of ⚫OH, O2⚫-, and carbon- or oxygen-centered organic radicals, and a …

Tietoturvan ihmiselementti : sosiaalinen manipulointi

2017

Tämän tutkielman aiheena on sosiaalinen manipulointi, tietoturvan ihmiselementti ja sen huomioon ottaminen ja hyökkäysten ehkäiseminen yrityksen tai organisaation tietoturvassa. Sosiaalisella manipuloinnilla tarkoitetaan tutkielman kontekstissa tietojärjestelmän käyttäjiin kohdistuvaa manipulointia, jonka tavoitteena on informaation keruu tai tietojärjestelmään murtautuminen. Aihetta on tärkeää tutkia, sillä useat tietoturva-asiantuntijat ovat yhtä mieltä siitä, että merkittävin tietojärjestelmän tietoturvauhka on sen käyttäjät ja heidän tietoturvallisuuden näkökulmasta tekemät inhimilliset erehdykset. Sosiaalinen manipulointi kohdistuu juuri tähän tietoturvan heikkouteen. Tutkielman tuloks…

Ground instability in the old town of Agrigento (Italy) depicted by on-site investigations and Persistent Scatterers data

2012

We combine on-site investigations with the interpretation of satellite Persistent Scatterers (PS) to analyse ground instability in the historic town of Agrigento, Italy. Geological and geomorphologic surveys, together with geostructural and kinematic analyses, depict the deformational patterns of the northwestern sector of the town, previously documented by extensive literature available for the neighbouring Valley of the Temples. The geological and geomorphologic maps are reconstructed by combining bibliographic studies, field surveys and aerial stereo-interpretation. ERS-1/2 PS data reveal deformation velocities up to 18–20 mm yr<sup>−1</sup> in 1992–2000 over the Addolorata l…

Maculare Pseudoforamenund Bestehen Hyaloider Arterien in Stark myelinisiertem retinalen Nervengewebe

2008

Maternal homework assistance and children's task-persistent behavior in elementary school

2018

Abstract The present study used a sample of 365 children to investigate the longitudinal associations between maternal homework assistance (i.e., help, monitoring, and autonomy granting) and children's task-persistent behavior in learning situations from grade 2 to grade 4 of elementary school. Also, the extent to which task-persistent behavior plays a role in the links between parental homework assistance and children's academic performance was examined. The results showed that the more autonomy granting mothers reported, the more task-persistent behavior children exhibited; and more task-persistent behavior children exhibited, the more autonomy their mothers granted. In contrast, the more…

Bioelectric model of atrial fibrillation: Applicability of blind source separation techniques for atrial activity estimation in atrial fibrillation e…

2003

In this contribution, we present the theoretical justification that give support to the suitability of blind signal separation (BSS) techniques for the estimation of the atrial activity (AA) present in ECGs of persistent atrial fibrillation (AF). The application of BSS methods to this problem needs the fulfillment of several conditions regarding AA, ventricular activity (VA) and the fashion in which both activities arise on the body surface, that will be justified along the paper. To empirically validate the model, an ICA method is applied to 10 real 12-lead recordings of AF. The identification of AA is put forward based on kurtosis and spectral analysis. The kurtosis value of the estimated…