Search results for "PERTURBATIONS"
showing 10 items of 25 documents
The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor
2021
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-stress-regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and non-neuronal damage. Although initially characterized as a secreted neurotrophic factor for midbrain dopamine neurons, MANF has recently gained more interest for its intracellular role in regulating the ER homeostasis, including serving as a cofactor of the chaperone glucose-regulated protein 78 (GRP78). We aimed for a better understanding of the neuroprotective mechanisms of MANF. Here we show for the first time that MANF promotes the survival of …
Adaptive synchronization of master-slave systems with mixed neutral and discrete time-delays and nonlinear perturbations
2011
This paper investigates the delay-dependent adaptive synchronization problem of the master and slave structure of linear systems with both constant neutral and time-varying discrete time-delays and nonlinear perturbations based on the Barbalat lemma and matching conditions. An adaption law which includes the master-slave parameters is obtained by using the Lyapunov functional method and inequality techniques to synchronize the master-slave systems without the knowledge of upper bounds of perturbation terms. Particularly, it is shown that the synchronization speed can be controlled by adjusting the update gain of the synchronization signal. A numerical example has been given to show the effe…
Quantifying Dynamic Balance in Young, Elderly and Parkinson's Individuals: A Systematic Review
2018
Introduction: Falling is one of the primary concerns for people with Parkinson's Disease and occurs predominately during dynamic movements, such as walking. Several methods have been proposed to quantify dynamic balance and to assess fall risk. However, no consensus has been reached concerning which method is most appropriate for examining walking balance during unperturbed and perturbed conditions, particularly in Parkinson's Disease individuals. Therefore, this systematic review aimed to assess the current literature on quantifying dynamic balance in healthy young, elderly and Parkinson's individuals during unperturbed and perturbed walking. Methods: The PubMed database was searched by ti…
Search for eccentric binary black hole mergers with advanced LIGO and advanced Virgo during their first and second observing runs
2019
When formed through dynamical interactions, stellar-mass binary black holes may retain eccentric orbits ($e>0.1$ at 10 Hz) detectable by ground-based gravitational-wave detectors. Eccentricity can therefore be used to differentiate dynamically-formed binaries from isolated binary black hole mergers. Current template-based gravitational-wave searches do not use waveform models associated to eccentric orbits, rendering the search less efficient to eccentric binary systems. Here we present results of a search for binary black hole mergers that inspiral in eccentric orbits using data from the first and second observing runs (O1 and O2) of Advanced LIGO and Advanced Virgo. The search uses min…
Stability analysis of neutral systems with mixed time-varying delays and nonlinear perturbations
2009
In this paper, the problem of stability analysis for a class of neutral systems with mixed time-varying neutral, discrete and distributed delays and nonlinear perturbations are addressed. By introducing a novel Lyapunov-Krasovskii functional and combining the descriptor model transformation, the Leibniz-Newton formula, some free weighting matrices and a suitable change of variables, new sufficient conditions are established for the stability of the considered system, which are neutral-delay-dependent, discrete-delay-range-dependent and distributed-delay-dependent. The conditions are presented in terms of linear matrix inequalities (LMIs) and can be easily solved by existing convex optimizat…
Tropical Temperate Toughs over southern Africa : mechanisms and evolution in response to climate change (2010-2099)
2014
In the Southern Hemisphere, Southern Africa and the south-west Indian Ocean are one of the three preferred regions where interactions between the tropics and midlatitudes develop. This is the South Indian Convergence Zone (SICZ), where northwest-southeast oriented cloud bands form at the synoptic scale (between 3 and 5 days). These bands are mainly found during the austral summer and are commonly referred to as tropical temperate troughs (TTTs). This research aims at improving our knowledge related to TTTs, with a study on the dynamics associated with these systems, and an analysis of their possible evolution during the 21st century.The first part of this thesis aims at identifying favorabl…
Robust Adaptive H∞ Synchronization of Master-Slave Systems with Discrete and Distributed Time-Varying Delays and Nonlinear Perturbations
2011
Author's version of a chapter published in the book: Proceedings of the 18th IFAC World Congress 2011. Also available from the publisher at: http://dx.doi.org/10.3182/20110828-6-IT-1002.03116
CMB spectral distortions in generic two-field models
2017
We investigate the CMB $\mu$ distortion in models where two uncorrelated sources contribute to primordial perturbations. We parameterise each source by an amplitude, tilt, running and running of the running. We perform a detailed analysis of the distribution signal as function of the model parameters, highlighting the differences compared to single-source models. As a specific example, we also investigate the mixed inflaton-curvaton scenario. We find that the $\mu$ distortion could efficiently break degeneracies of curvaton parameters especially when combined with future sensitivity of probing the tensor-to-scalar ratio $r$. For example, assuming bounds $\mu < 0.5 \times 10^{-8}$ and $r<0.0…
A new testing device for the role of the trunk in force production and in balance control in disabled sitting athletes
2017
In cross-country sit-skiing all athletes compete in a sitting position, but some of them have the ability to control their trunk more than others. The trunk plays an essential role in two performance determinants: propulsion generation and balance maintenance. The aim of the study is to design a new testing device assessing athletes’ responses to these propulsion determinants. The new device was composed of a seat surrounded by a sensorized aluminum frame. To assess propulsion generation, two force sensors were mounted in the anterior and posterior side of the frame, while two force sensors were embedded in two ropes elongated from the top of the frame. To measure trunk control, the device …
Slow-roll corrections in multi-field inflation: a separate universes approach
2018
In view of cosmological parameters being measured to ever higher precision, theoretical predictions must also be computed to an equally high level of precision. In this work we investigate the impact on such predictions of relaxing some of the simplifying assumptions often used in these computations. In particular, we investigate the importance of slow-roll corrections in the computation of multi-field inflation observables, such as the amplitude of the scalar spectrum $P_\zeta$, its spectral tilt $n_s$, the tensor-to-scalar ratio $r$ and the non-Gaussianity parameter $f_{NL}$. To this end we use the separate universes approach and $\delta N$ formalism, which allows us to consider slow-roll…