Search results for "PES"
showing 10 items of 5212 documents
Differential haplotypic expression of the interleukin-18 gene
2007
Interleukin 18 (IL-18) is suspected to play an important role in atherosclerosis and plaque vulnerability. We had previously shown that haplotypes combining two IL18 gene polymorphisms in complete linkage disequilibrium, C-105T (rs360717) in 5'-untranslated region (UTR) and A+183G (rs5744292) in 3'-UTR, were related to IL-18 circulating levels and cardiovascular outcome, the C(-105) G(+183) haplotype being associated with lower IL-18 levels and lower cardiovascular risk. This study was aimed at investigating the functional role of the two polymorphisms and their haplotypes on IL18 expression levels. Allelic imbalance experiments conducted in 24 and 20 subjects heterozygous for the C-105T an…
Determination of extremely low (236)U/(238)U isotope ratios in environmental samples by sector-field inductively coupled plasma mass spectrometry usi…
2005
A method by inductively coupled plasma mass spectrometry (ICP-MS) was developed which allows the measurement of (236)U at concentration ranges down to 3 x 10(-14)g g(-1) and extremely low (236)U/(238)U isotope ratios in soil samples of 10(-7). By using the high-efficiency solution introduction system APEX in connection with a sector-field ICP-MS a sensitivity of more than 5,000 counts fg(-1) uranium was achieved. The use of an aerosol desolvating unit reduced the formation rate of uranium hydride ions UH(+)/U(+) down to a level of 10(-6). An abundance sensitivity of 3 x 10(-7) was observed for (236)U/(238)U isotope ratio measurements at mass resolution 4000. The detection limit for (236)U a…
La Kalsa è un giardino. Resistenza e partecipazione alla vita urbana del centro storico di Palermo, dei ruderi di guerra e della vegetazione spontane…
2023
Palermo è molti paesaggi; è una geografia di luoghi esagerati in grado di generare una condizione di costante stupore in chi la attraversi. Le molte anime di popoli diversi che l’hanno abitata e di quelli che ancora la abitano costituiscono un mosaico fatto di relazioni strettissime e inedite tra piante, animali, uomini, mare e luce. Il presente contributo intende restituire una lettura (certamente non esaustiva in quanto sarebbe impossibile farlo), di alcune condizioni di convivenza che sono state osservate all’interno degli spazi aperti della città (in particolare nel suo quartiere Kalsa). Queste sono interessanti perché ci mostrano come legami spontanei tra specie viventi e oggetti diver…
High yielding one-pot enzyme-catalyzed synthesis of UDP-glucose in gram scales
2001
Abstract Uridine diphosphoglucose is an important cofactor of glucosylating enzymes. A simple and high yielding one-pot enzymatic synthesis of UDPG on a gram scale from glucose via hexokinase, phosphoglucomutase and UDPG pyrophosphorylase (UGPase) is described. Repetitive addition of substrate was used to avoid inhibition of UGPase. The approach allows recovery of active enzymes and their re-use. The synthesis of UDP-[4-13C]-glucose on a 0.5 g scale resulted in a final yield of 70% and a purity of >95% after chromatographic purification.
Retrospective analysis of pesticide metabolites in urine using liquid chromatography coupled to high-resolution mass spectrometry
2016
Abstract A comprehensive retrospective analysis of pesticide metabolites in urine was developed, using liquid chromatography coupled to Orbitrap high-resolution mass spectrometry (UHPLC-HRMS) that includes both post-run target (suspect screening) and non-target screening. An accurate-mass database comprising 263 pesticide metabolites was built and used for the post-run screening analysis. For non-target analysis, a “fragmentation-degradation” relationship strategy was selected. The proposed methodology was applied to 49 real urine samples from pregnant women. In the post-target analysis 26 pesticide metabolites were tentatively identified, 8 of which (2-diethylamino-6-methyl-pyrimidinol; 3-…
Study of USH1 Splicing Variants through Minigenes and Transcript Analysis from Nasal Epithelial Cells
2012
Usher syndrome type I (USH1) is an autosomal recessive disorder characterized by congenital profound deafness, vestibular areflexia and prepubertal retinitis pigmentosa. The first purpose of this study was to determine the pathologic nature of eighteen USH1 putative splicing variants found in our series and their effect in the splicing process by minigene assays. These variants were selected according to bioinformatic analysis. The second aim was to analyze the USH1 transcripts, obtained from nasal epithelial cells samples of our patients, in order to corroborate the observed effect of mutations by minigenes in patient’s tissues. The last objective was to evaluate the nasal ciliary beat fre…
Ikdienas ieradumu un viscerālo tauku ietekme uz muguras lejasdaļas sāpēm cilvēkiem ar normālu ķermeņa masas indeksu
2019
Darba nosaukums: Ikdienas ieradumu un viscerālo tauku ietekme uz muguras lejasdaļas sāpēm cilvēkiem ar normālu ĶMI. Tiek uzskatīts, ka mugurkaulāja problēmas, tāpat kā aptaukošanās ir izplatīta problēma straujā dzīvesveida izmaiņu un tehnoloģiju attīstības dēļ. Tomēr nav skaidri izprasts patoģenēzes mehānisms, kas rada muguras lejasdaļas sāpes. Kā dažus no iespējamiem iemesliem literatūrā atzīmē faktorus, kas tieši vai netieši saistīti ar viscerālo tauku uzkrāšanos (Schepper et al. 2010; De Almeida et al. 2007). Taukaudu veidošanās process ir sarežģīts un vēl nav pietiekami izskaidrots (Currie et al. 2012). Mērķis: Noskaidrot ikdienas paradumu ietekmi uz muguras lejasdaļas sāpēm un šo sāpju…
SIA “Tukuma slimnīcas” darbības analīze un attīstības iespējas veselības nozarē
2018
Bakalaura darba tēma ir „SIA „Tukuma slimnīca” darbības analīze un attīstības iespējas veselības nozarē”. Darba autore ir Anija Rabkeviča. Darba mērķis ir uz veiktās SIA „Tukuma slimnīca” darbības analīzes pamata novērtēt uzņēmuma spēju nodrošināt noteikto veselības aprūpes līmeni un izstrādāt priekšlikumus attīstībai. Kvalifikācijas darbs sastāv no ievada, piecām nodaļām, secinājumiem un priekšlikumiem, izmantotās literatūras un avotu saraksta. Pirmajā nodaļā autore veica pētāmā jautājuma teorētisko pamatojumu. Noskaidroti veselības aprūpi reglamentējošie normatīvie akti. Otrajā nodaļā tika izpētīts SIA „Tukuma slimnīcas” darbības raksturojums. Trešajā nodaļā autore izpētījusi uzņēmuma iek…
SIA “Elfa”konkurētspēja un attīstības iespējas Kurzemes reģionā
2018
Bakalaura darba autors ir Kaspars Stiurenieks. Bakalaura darba tēma: „SIA „Elfa” konkurētspēja un attīstības iespējas Kurzemes reģionā”. Bakalaura darba mērķis ir analizēt uzņēmuma SIA „Elfa” konkurētspēju un izstrādāt ieteikumus turpmākās darbības attīstības iespējām Kurzemes reģionā. Darba pirmajā nodaļā autors sniegs konkurētspējas un konkurences teorētisko raksturojumu. Tiks skaidrots, kā vislabāk salīdzināt konkurentus ar savu uzņēmumu, pievēršot uzmanību uz konkurences vājību un priekšrocību noteikšanu. Otrajā nodaļā autors veiks SIA „Elfa” izvērsto analīzi. Tiks salīdzinātas teorētiski iegūtās zināša-nas ar praktiski iegūto informāciju par uzņēmumu. Trešajā nodaļā tiks izpētīta un an…
Movement patterns of temperate wrasses (Labridae) within a small marine protected area
2021
The movement patterns of three commercially important wrasse (Labridae) species inside a small marine protected area (~ 0.15 km2 ) on the west coast of Norway were analysed over a period of 21 months. The mean distance between capture and recapture locations varied between 10 and 187 m, and was species and season specific. The extent of movement was not related to body size or sex. These results imply that a network of small strategically located marine protected areas can be used as management tools to protect wrasses from size- and sex-selective fishing mortality.