Search results for "PES"
showing 10 items of 5212 documents
Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer ste…
2018
Despite marked advancements in its treatment, breast cancer is still the second leading cause of cancer death in women, due to relapses and distal metastases. Breast cancer stem cells (CSCs), are a cellular reservoir for recurrence, metastatic evolution and disease progression, making the development of novel therapeutics that target CSCs, and thereby inhibit metastases, an urgent need. We have previously demonstrated that the cystine-glutamate antiporter xCT (SLC7A11), a protein that was shown to be overexpressed in mammary CSCs and that plays a key role in the maintenance of their redox balance, self-renewal and resistance to chemotherapy, is a potential target for mammary cancer immunoth…
Prediction of Specific TCR-Peptide Binding From Large Dictionaries of TCR-Peptide Pairs
2019
Abstract The T cell repertoire is composed of T cell receptors (TCR) selected by their cognate MHC-peptides and naive TCR that do not bind known peptides. While the task of distinguishing a peptide-binding TCR from a naive TCR unlikely to bind any peptide can be performed using sequence motifs, distinguishing between TCRs binding different peptides requires more advanced methods. Such a prediction is the key for using TCR repertoires as disease-specific biomarkers. We here used large scale TCR-peptide dictionaries with state-of-the-art natural language processing (NLP) methods to produce ERGO (pEptide tcR matchinG predictiOn), a highly specific classifier to predict which TCR binds to which…
Control of Murine Cytomegalovirus Infection by γδ T Cells
2015
Infections with cytomegalovirus (CMV) can cause severe disease in immunosuppressed patients and infected newborns. Innate as well as cellular and humoral adaptive immune effector functions contribute to the control of CMV in immunocompetent individuals. None of the innate or adaptive immune functions are essential for virus control, however. Expansion of γδ T cells has been observed during human CMV (HCMV) infection in the fetus and in transplant patients with HCMV reactivation but the protective function of γδ T cells under these conditions remains unclear. Here we show for murine CMV (MCMV) infections that mice that lack CD8 and CD4 αβ-T cells as well as B lymphocytes can control a MCMV i…
Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space
2019
Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different individuals remain poorly understood. To quantitatively describe epitope immunogenicity, here we propose a supervised machine learning framework generating probabilistic estimates of immunogenicity, termed "immunogenicity scores," based on the numerical features computed through sequence-based simulation approximating the molecular scanning process of peptides presented onto major histocompatibility complex (MHC) by the human T cell receptor (T…
Informar es denunciar. Entrevista a Ulderico Pesce
2016
Ulderico Pesce, de quien traducimos en este número de Zibaldone. Estudios italianos uno sus textos más significativos, Asso di monnezza, nos da en la siguiente entrevista algunas claves sobre su dramaturgia.
The attenuation and the attenuators: strategies and tactics
2013
Este trabalho se inscreve em um projeto de pesquisa (ES.POR.ATENUAÇÃO) que busca analisar e explicar a atividade atenuadora em diferentes variedades regionais do espanhol e do português, com o fim de realizar, posteriormente, diferentes estudos contrastivos intralinguísticos e interlinguísticos. Neste artigo, pretendemos explicar alguns dos princípios teóricos e metodológicos nos quais se sustenta a análise qualitativa e quantitativa. E, principalmente, iremos referir-nos ao conceito de atenuação (Briz 1995, 2002, 2003, 2005, 2007a, 2012). This work is inscribed in a research project (ES.POR.ATENUAÇÃO) that seeks to analyze and explain the attenuator activity in different regional varieties…
As de basura. El tráfico ilegal de residuos
2016
Ulderico Pesce (Rivello, 1963), uno de los más significativos autores-narradores del teatro de narración de marcado contenido civil, vuelve a tratar en Asso di Monnezza el inmenso problema del lucrativo reciclaje de deshechos, sobre todo industriales, en la Italia actual. No es esta la primera vez que trata el tema, aunque en esta ocasión, partiendo de la visión directa del joven Nicola, se centra en la sangrante connivencia entre mafia, entidades públicas y los bajos fondos metropolitanos. En esta línea de denuncia social se mueven, de hecho, todos sus espectáculos de narración en la línea del llamado teatro civile, como Storie di scorie. Il pericolo nucleare in Italia, sobre el peligro n…
Situación actual en España de los aerosoles insecticidas registrados en sanidad ambiental para uso doméstico
2003
Fundamentos: La reciente transposición de la Directiva de Biocidas a través del Real Decreto 1.054/2002 conllevará un cambio sustancial en distintos aspectos de la Sanidad Ambiental. Para evaluar la incidencia de estos cambios se presenta un análisis de la situación actual, a partir del cual se podrán valorar adecuadamente las consecuencias de la implantación de la Directiva en España, así como establecer los aspectos básicos que se deben analizar con vistas al establecimiento de un Registro de Biocidas acorde con dicho Real Decreto. Métodos: El análisis se ha efectuado a partir de los datos que figuran en la base de datos del Ministerio de Sanidad y Consumo sobre los insecticidas registrad…
Burnout, work engagement and workaholism among highly educated employees: Profiles, antecedents and outcomes
2014
The present study examined the longitudinal profiles of burnout, engagement and workaholism among highly educated employees. First, the latent profile modeling indicated two latent classes: Engaged and Exhausted-Workaholic. Second, the results revealed that employees with the Engaged profile experienced high levels of energy and dedication, whereas employees with the Exhausted-Workaholic profile experienced exhaustion, cynicism and workaholism. Social pessimism in the transition from high education to work predicted poor subjective well-being at work. Further, workaholism decreased during the career among members of the Exhausted-Workaholic profile suggesting positive direction during caree…
Do native white-clawed crayfish impact macroinvertebrate assemblages in Mediterranean limestone headwaters?
2019
Crayfish are among the largest aquatic macroinvertebrates in rivers and streams. Their trophic ecology is important for the understanding of the functioning of benthic communities. This is relevant in key areas, such as headwaters, as they partly condition the processes occurring downstream. To shed light on the effects of native white-clawed crayfish,Austropotamobius pallipes, on local macroinvertebrate assemblages from running headwaters, a three-month mesocosm-based field study was designed. Collection and subsequent analysis of benthic samples under different crayfish density levels yielded a set of metrics indicative of short-term impacts at general and taxonomic scales. Neither signif…