Search results for "PGE"
showing 10 items of 40 documents
2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors
2016
International audience; 2,3-Dihydrobenzofurans are proposed as privileged structures and used as chemical platform to design small compound libraries. By combining molecular docking calculations and experimental verification of biochemical interference, we selected some potential inhibitors of microsomal prostaglandin E2 synthase (mPGES)-1. Starting from low affinity natural product 1, by our combined approach we identified the compounds 19 and 20 with biological activity in the low micromolar range. Our data suggest that the 2,3-dihydrobenzofuran derivatives might be suitable bioinspired lead compounds for development of new generation mPGES-1 inhibitors with increased affinity.
Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses
2017
Sickness responses to lipopolysaccharide (LPS) were examined in mice with deletion of the interleukin (IL)-1 type 1 receptor (IL-1R1). IL-1R1 knockout (1(0) mice displayed intact anorexia and HPA-axis activation to intraperitoneally injected LPS (anorexia: 10 or 120 mu g/kg; HPA-axis: 120 mu g/kg), but showed attenuated but not extinguished fever (120 g/kg). Brain PGE2 synthesis was attenuated, but Cox-2 induction remained intact. Neither the tumor necrosis factor-alpha (TNF alpha) inhibitor etanercept nor the IL -6 receptor antibody tocilizumab abolished the LPS induced fever in IL -1R1 KO mice. Deletion of IL -1R1 specifically in brain endothelial cells attenuated the LPS induced fever, b…
Genome-wide diversity and runs of homozygosity in the “Braque Français, type Pyrénées” dog breed
2018
Objective Braque Français, type Pyrénées is a French hunting-dog breed whose origin is traced back to old pointing gun-dogs used to assist hunters in finding and retrieving game. This breed is popular in France, but seldom seen elsewhere. Despite the ancient background, the literature on its genetic characterization is surprisingly scarce. A recent study looked into the demography and inbreeding using pedigree records, but there is yet no report on the use of molecular markers in this breed. The aim of this work was to genotype a population of Braque Français, type Pyrénées dogs with the high-density SNP array to study the genomic diversity of the breed. Results The average observed (\docum…
The role of extracellular calcium in bone metastasis
2016
AbstractThis review summarizes the role of extracellular calcium, as found present in the bone tissue, in the process of bone metastasis.
Response of AGATA segmented HPGe detectors to gamma rays up to 15.1MeV
2013
WOS: 000314826000009
Récit d’un « tremplin ». Des bacheliers professionnels en classe préparatoire
2021
International audience; Rares sont les bacheliers professionnels à déjouer les statistiques en s’orientant vers une classe préparatoire aux grandes écoles. L’audace des bacheliers professionnels, peu préparés aux exigences académiques des cursus longs et engagés dans une voie où ils sont traditionnellement moins attendus, interpelle. Comment ces jeunes justifient-ils ce parcours improbable ? Les propos des bacheliers professionnels rencontrés sont révélateurs à la fois de la représentation qu’ils se font de leur orientation, de la place qu’ils « rêvent » dans la société à venir et aussi du niveau de confiance dans leurs « capacités » à y parvenir. Dans un cadre stimulant, l'horizon des écol…
Efficience de l'enseignement supérieur dans la production des élites
2004
International audience
Studio di modelli equivalenti per la simulazione con il codice PENELOPE della risposta in efficienza di un rivelatore HPGe
2017
La simulazione della risposta di un rivelatore HPGe con l’impiego di codici Monte Carlo è una tecnica ormai diffusamente impiegata e particolarmente utile per la valutazione di efficienze quando non sono disponibili standards di calibrazione con stessa forma e composizione del campione in esame. Il risultato della simulazione dipende dalla conoscenza più o meno dettagliata delle caratteristiche del rivelatore, atte a definire un “modello” dello stesso. Per evidenziare anche quelle parti non definite nella certificazione del costruttore, solitamente si effettua una radiografia del rivelatore fatta eccezione per i casi in cui non è realizzabile pena lo smontaggio della struttura di schermatur…
Evaluation des compétences des anciens élèves des classes préparatoires scientifiques par leurs performances scolaires et professionnelles
2004
International audience
Equivalent detector models for the simulation of efficiency response of an HPGe detector with PENELOPE code
2019
Monte Carlo simulation of response of an HPGe detector is a widely used technique to evaluate counting efficiencies. It is particularly useful when calibration standards with the same shape and composition of the sample under examination are not available. The result of the simulation depends on the more or less detailed knowledge of the characteristics of the detector, able to define a "model" of the same detector. To highlight parts not well defined in the manufacturer's certification, a detector X-ray analysis is usually performed, except in cases when it is not possible to dismantle the shielding structure with the loss of previous calibration data. In this work, in absence of some data…