Search results for "PIDE"

Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and positively associated with H…

2011

Abstract Background There is increasing evidence for the role of High Risk (HR) Human PapillomaVirus (HPV) in the pathogenesis of Oral Squamous Cell Carcinoma (OSCC). The E6 and E7 oncogenes from HR HPVs are responsible for the deregulation of p53 and pRB proteins involved in cell cycle and apoptotic pathways. In cell lines experiments, the HPV E7 protein seems to be able to enhance Hypoxia Inducible Factor-1 alpha (HIF-1α) activity, normally involved in the response to hypoxia and able to enhance angiogenesis. Results We studied tumor specimens from 62 OSCC; a higher prevalence of tumors in TNM stage II and also in pT2 class between OSCC infected positive HPV16 DNA than non-infected ones w…

Difficulties encountered in estimating disability related to mental disorders in a general population survey. The French Disability and Health Survey…

2014

A better understanding of disability phenomenon linked to mental disorders is a main issue in France. The data collected in the Disability and Health Survey carried out in France in 2008 and 2009 among the general population could help reach that aim. The methodological point of view of this article aims at showing why improving the knowledge concerning disability linked to mental disorders remains a difficult task, even when the collected data cover the entire spectrum of health and disability (including environmental information).The first categories of difficulties derive from the lack of consensus about the definition of disability linked to mental disorders –named “Handicap psychique” …

Sentieri: mortality, cancer incidence and hospital discharges. Summary

2014

Modelling the presence of disease under spatial misalignment using Bayesian latent Gaussian models.

2015

Modelling patterns of the spatial incidence of diseases using local environmental factors has been a growing problem in the last few years. Geostatistical models have become popular lately because they allow estimating and predicting the underlying disease risk and relating it with possible risk factors. Our approach to these models is based on the fact that the presence/absence of a disease can be expressed with a hierarchical Bayesian spatial model that incorporates the information provided by the geographical and environmental characteristics of the region of interest. Nevertheless, our main interest here is to tackle the misalignment problem arising when information about possible covar…

Socio-environmental variables and transmission risk of lymphatic filariasis in central and northern Mozambique

2013

Lymphatic filariasis (LF) is endemic in Mozambique, where it is caused by Wuchereria bancrofti with Culex quinquefasciatus as the main vector. It affects approximately 10% of the population (2 million) with about 16 million at risk. Prevalence rates in 40 out of 65 districts that together comprise the four endemic provinces Niassa, Cabo Delgado, Nampula and Zambezia were analysed with the aim of elucidating the socio-environmental variables influencing the transmission. The levels of prevalence were divided into six ranks and certain climatic, environmental and social factors were considered independent variables. A climadiagram was created and the LF risk and the water budget-based index w…

A comprehensive one-year correlation analysis between prevalence and number of sars-cov-2 rna copies detected in wastewater from 8 sicilian cities in…

2023

Background and objectives: Several authors have reported positive correlations between wastewater SARS-CoV-2 concentrations and the community’s burden of infection, providing information about the disease’s epidemiological trend. This pre-post study evaluated – within a year of active surveillance, from October 1st,2021, to September 30th, 2022 – the relation between daily SARSCoV-2 prevalence and the number of genome copies/L detected in West Sicily wastewater samples. This study is part of a national framework coordinated by Istituto Superiore di Sanità. Methods: Quantitative data from analysing 486 wastewater samples collected from 9 purification plants in 8 Sicilian cities (Agrigento, B…

Spatio-temporal cluster detection of chickenpox in Valencia, Spain in the period 2008-2012.

2015

Chickenpox is a highly contagious airborne disease caused by <em>Varicella zoster</em>, which affects nearly all non-immune children worldwide with an annual incidence estimated at 80-90 million cases. To analyze the spatiotemporal pattern of the chickenpox incidence in the city of Valencia, Spain two complementary statistical approaches were used. First, we evaluated the existence of clusters and spatio-temporal interaction; secondly, we used this information to find the locations of the spatio-temporal clusters via the space-time permutation model. The first method used detects any aggregation in our data but does not provide the spatial and temporal information. The second me…

Depressive symptoms in late life : Results from a study in three Nordic urban localities.

1995

The prevalence and correlates of depressive symptoms among 75-year-olds were examined in three Nordic urban localities: Gothenburg, Sweden (n=446), Jyvaskyla, Finland (n=382) and Glostrup, Denmark (n=541). Depressive symptomatology was assessed with the Center for Epidemiologic Studies Depression Scale (CES-D). Prevalence figures for depressiveness seemed to be somewhat higher in Jyvaskyla than in the two other localities. Women had more depressive symptoms than men in all three areas. The lowest mean score was recorded for Danish men and the highest level of symptoms in Finnish women. The associations discovered in this Nordic comparative study between demographic characteristics and depre…

Smoking cessation opportunities in severe mental illness (tobacco intensive motivational and estimate risk — TIMER—): study protocol for a randomized…

2019

There is an increased risk of premature death in people with severe mental illness (SMI). Respiratory disorders and cardiovascular disease are leading causes of increased mortality rates in these patients, and tobacco consumption remains the most preventable risk factor involved. Developing new tools to motivate patients towards cessation of smoking is a high priority. Information on the motivational value of giving the lung age and prevention opportunities is unknown in this high-risk population. In the context of community care, screening and early detection of lung damage could potentially be used, together with mobile technology, in order to produce a prevention message, which may provi…

Association Between Pollution and Frailty in Older People: A Cross-Sectional Analysis of the UK Biobank

2023

Objectives: Frailty is a relevant issue in older people, being associated with several negative outcomes. Increasing literature is reporting that pollution (particularly air pollution) can increase the risk of frailty, but the research is still limited. We aimed to investigate the potential association of pollution (air, noise) with frailty and prefrailty among participants 60 years and older of the UK Biobank study. Design: Cross-sectional. Settings and participants: Older participants (age ≥ 60 years) participating to the UK Biobank. Methods: Frailty and prefrailty presence were ascertained using a model including 5 indicators (weakness, slowness, weight loss, low physical activity, and e…