Search results for "PIDE"
showing 10 items of 6055 documents
Epidemiology of hepatitic C infection in hemodialysis patients of Sicily
2008
2019
Contamination of fresh water bodies by human enteric viruses from wastewater discharge is a well-established phenomenon. Here we propose a model of viral contamination of rivers based on acute gastroenteritis epidemiology and assess how well it can simulate in situ experimental monitoring. Noroviruses, rotaviruses, enteroviruses, adenoviruses and hepatitis A viruses were quantified by molecular methods after water concentration. Water flows were obtained from the Hydro databank and wastewater treatment plant (WWTP) data. Acute gastroenteritis cases based on medical prescriptions were recorded by the French public health agency. We estimated the total number of daily viral acute gastroenteri…
Epidemiology, risk factors and surveillance of hepatocellular carcinoma
2010
Hepatocellular carcinoma (HCC) is a challenging malignancy of global importance, it is associated with a high rate of mortality and its prevalence in the United States and in Western Europe is increasing. Cirrhosis is the strongest and the most common known risk factor for hepatocellular carcinoma, particularly cirrhosis related to hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. The stage of cancer dictates the therapeutic choice, making early detection a primary objective. Early diagnosis of hepatocellular carcinoma is feasible because HCC develops in the background of well-known, readily identifiable and potentially avoidable environmental risk factors. Many observational …
Stimulation of pancreas and gastric carcinoma cell growth by interleukin 3 and granulocyte-macrophage colony-stimulating factor.
1991
Hematopoietic growth factors have recently been well characterized by complementary DNA scloning. For human epidermal growth factor, granulocyte-macrophage colony-stimulating factor recombinant proteins have been expressed in Escherichia coli . To reduce the toxic side effects of chemotherapy on the bone marrow, recombinant human granulocyte-macrophage colony—stimulating factor and recombinant human interleukin 3 were applied to patients suffering of gastrointestinal cancers. To determine the influence of recombinant human granulocyte-macrophage colony—stimulating factor and recombinant human interleukin 3 on human pancreas and gastric cancer cell cells in vitro, a sensitive microculture te…
Etude et modélisation du comportement des gouttelettes de produits phytosanitaires sur les feuilles de vignes par imagerie ultra-rapide et analyse de…
2013
In the domain of vineyard precision spraying research, one of the most importantobjectives is to minimize the volume of phytosanitary products ejected bya sprayer in order to be more environmentally respectful with more effectivevine leaf treatments. Unfortunaltely, even if lot of works have been carriedout at a parcel scale, mainly on losses caused by drift, less works have beencarried out at the leaf scale in order to understand which parameters influencethe spray quality. Since few years, recent improvements in image processing,sensitivity of imaging systems and cost reduction have increased the interestof high-speed imaging techniques. Analyzing the behavior of droplets afterimpact with…
Sequence, evolution and tissue expression patterns of an epidermal type I keratin from the shark Scyliorhinus stellaris.
2004
From the shark Scyliorhinus stellaris we cloned and sequenced a cDNA encoding a novel type I keratin, termed SstK10. By MALDI-MS peptide mass fingerprinting of cytoskeletal proteins separated on polyacrylamide gels, we assigned SstK10 to a 46-kDa protein which is the major epidermal type I (“IE”) keratin in this fish and is specifically expressed in stratified epithelia. In a phylogenetic tree based on type I keratin sequences and with lamprey keratins applied as outgroup, SstK10 branches off in a rather basal position. This tree strongly supports the concept that teleost keratins and tetrapod keratins resulted from two independent gene radiation processes. The only exception is human K18 b…
Epidermal IL-17A leads to bone loss through inhibition of osteoblast differentiation
2012
The AP-1 transcription factor family is a central regulator of skin and bone homeostasis. We have previously shown that specific deletion of JunB/AP-1 in epidermis (JunBmice) results in skin inflammation,myeloproliferative disease, lupus-like disease and osteopenia. While upregulation of serum IL-6 and G-CSF are observed in this model, genetic deletion of these cytokines does not rescue osteopenia in JunB mice. Thus, we carried out a screen for other cytokines that are regulated by the loss of JunB in the epidermis. We have identified IL-17A as a cytokine expressed in JunB epidermis in vivo, and hypothesize that IL-17A leads to osteopenia in JunBmice. To test this,we carried out osteoblast …
Histochemical and biochemical investigations concerning the function of larval oenocytes of Tenebrio molitor L. (Coleoptera, Insecta).
1980
Larval oenocytes of Tenebrio molitor were investigated histochemically. In contrast to the lipid droplets of the fat body, they did not stain with Sudan black. A positive reaction for lipoproteins appeared only after destructive oxidation with sodium hypochlorite. These lipoproteins are the remnants of degenerated membranes, as revealed by ultrastructural analysis. Polyphenols could be identified in the exocuticle of exuvia, and in the newly formed procuticle. Endocuticle, epidermis and oenocytes showed no staining reaction. In oenocytes a great amount of lipase is also present which could be detected with several Tweens as substrates. The significance of these lipases remains unclear, sinc…
Historia natural y clasificación de la infección por VIH-1
2002
El espectro de la infección por VIH varía ampliamente desde la infección asintomática hasta una fase de inmunodeficiencia celular grave. Factores dependientes del virus, del huésped y cofactores ambientales condicionan la gran variabilidad existente en la pro¬gresión a SIDA. La carga vírica y el nivel de linfocitos CD4+ se han perfilado como los parámetros más útiles para predecir la evolución a SIDA. En los últimos años con la introducción de la terapia antirretrovírica de alta eficacia se está observando un cam¬bio en la historia natural de la infección, con un marcado descenso de la mortalidad por SIDA, apreciándose un incremento en la mortalidad por causas independientes del propio VIH,…
Una mirada histórico-geográfica de las pandemias : para entender de manera compleja la COVID-19 pandemias
2021
El abordaje para la investigación de brotes/pandemias es una actividad desafiante, necesaria y retadora para los salubristas y epidemiólogos. Esta actuación permite que los servicios de epidemiología y de vigilancia profundicen el conocimiento de la enfermedad, recaben datos históricos de episodios pandémicos, caractericen vulnerables, planteen hipótesis e intervengan los factores de riesgos en un contexto ambiental y sociocultural determinado con una actuación local y una perspectiva global. Se considera un abordaje sindémico, de tal manera que conjugan aspectos de determinantes sociales interconectados y profundizando en la pandemia. The outbreak/pandemic investigation approach is a chall…