Search results for "PIDE"

Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits

2014

In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a single nucleotide in the APOB mRNA by the APOBEC1 enzyme. The APOB48 protein is mandatory for the synthesis of chylomicrons by intestinal cells to transport dietary lipids and cholesterol. We produced transgenic rabbits expressing permanently and ubiquitously a small hairpin RNA targeting the rabbit APOBEC1 mRNA. These rabbits exhibited a moderately but significantly reduced …

Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019)

2021

© 2021 by the authors.

Disumano, troppo umano. La maschera del tiranno e l’antropologia dei filosofi (da Sofocle a Seneca)

2019

Tyranny is often regarded as "a perennial problem" (Boesche 1996) on the basis of its ubiquitous presence in literature. Even more enduring is the problem of how to define human nature, its place in the environment, and its relationship to the divine – a core issue of philosophical anthropology (Pansera 2001, Honenberger 2015). In the present paper, I shall approach the literary construction of the tyrant figure in Greek and Roman tragedy from the holistic perspective of philosophical anthropology. I will focus on three well-known dramas (Sophocles’ Oedipus the King and Antigone and Seneca’s Thyestes) which put great emphasis on the moral and cognitive status of tyrants as “exceptional” hum…

Plasmalogens, polyunsaturated fatty acids (PUFA), and glaucoma

2012

Métabolisme des plasmalogènes dans les tissus neveux : implication dans le développement vasculaire rétinien par l'intermédiaire de la phospholipase …

2013

Les complications vasculaires rétiniennes constituent des évènements qui peuvent être observés au cours de rétinopathies pouvant être à l’origine d’une cécité à tous les stades de la vie. Ces complications concernent particulièrement la rétinopathie du prématuré, la rétinopathie diabétique et la dégénérescence maculaire liée à l’âge. Les lipides offrent de nombreuses possibilités pour prévenir et éventuellement freiner le développement de ces rétinopathies. Parmi eux, la classe des plasmalogènes est particulièrement riche en acides gras poly-insaturés (AGPI), qui sont libérés par une phospholipase indépendante du calcium (iPLA2) et qui sont précurseurs de métabolites biologiquement actifs. …

Plasmalogens, erythrocyte deformability, and retinal vascular development

2014

Presidentti 2000 : mistä vaalit on tehty?

2000

Pysyvää ehkäisymenetelmää etsimässä

2022

Osa vapaaehtoisesti lapsettomista henkilöistä haluaisi hakeutua pysyvän ehkäisykeinon tarjoavaan sterilisaatiotoimenpiteeseen. Suomen steriloimislaissa määriteltyjen kriteerien vuoksi he joutuvat kuitenkin yleensä odottamaan kolmenkymmenen vuoden ikärajan täyttymistä saadakseen lähetteen toimenpiteeseen. Toimenpiteen tiukka sääntely viestii siitä, että kulttuurissamme elää yhä vahvoja lisääntymiseen liittyviä normeja. nonPeerReviewed

Palermo 2018 i portali. Architetture e culture della tradizione costruttiva siciliana

2018

Il viaggio tra i portali monumentali è una rivisitazione inedita della città. Fare un giro nel centro storico di Palermo è un vero e proprio viaggio nella storia che solo un occhio attento e preparato comprende. I segni della sua ori- gine sono ancora leggibili, così come le sue trasformazioni sono impresse, nelle strade e nelle facciate di palazzi e chiese. Il fascino di questa città sta forse proprio in queste modificazioni e sovrapposizioni, in questa ricerca del documento che è storia e tecnologia insieme perché la storia si è impressa nella materia che la sostanzia. Lo studio dei portali di Palermo è frutto di una ricerca internazionale che ha per tema la lettura del costruito storico …

Clinical characteristics and predictors of death among hospitalized patients infected with SARS‑CoV‑2 in Sicily, Italy: A retrospective observational…

2022

Since late December 2019, severe acute respiratory syndrome coronavirus 2 has spread across the world, which resulted in the World Health Organization declaring a global pandemic. Coronavirus disease 2019 (COVID-19) presents a highly variable spectrum with regard to the severity of illness. Most infected individuals exhibit a mild to moderate illness (81%); however, 14% have a serious disease and 5% develop severe acute respiratory distress syndrome (ARDS), requiring intensive care support. The mortality rate of COVID-19 continues to rise across the world. Data regarding predictors of mortality in patients with COVID 19 are still scarce but are being actively investigated. The present multi…