Search results for "PIE"

L'abbaye Saint-Pierre de Flavigny à l'époque carolingienne

1977

International audience; C’est sur un site privilégié, promontoire rocheux dominant la petite vallée de l’Ozerain, et à proximité de l’antique Alésia (à 60 kilomètres au Nord-Est de Dijon) que fut fondée, au début du VIlle siècle, l’abbaye Saint-Pierre de Flavigny. Elle fut l’objet de plusieurs constructions successives, dont certains vestiges, encore visibles de nos jours, nous éclairent sur son architecture à l’époque carolingienne. Plus de quinze ans se sont écoulés depuis les derniers travaux effectués dans l’abbaye, et nous avons pensé qu’il était nécessaire de faire le point sur ce que nous pouvons savoir de cet édifice et de son contexte historique. Nous examinerons notamment certains…

Abel transforms with low regularity with applications to X-ray tomography on spherically symmetric manifolds

2017

We study ray transforms on spherically symmetric manifolds with a piecewise $C^{1,1}$ metric. Assuming the Herglotz condition, the X-ray transform is injective on the space of $L^2$ functions on such manifolds. We also prove injectivity results for broken ray transforms (with and without periodicity) on such manifolds with a $C^{1,1}$ metric. To make these problems tractable in low regularity, we introduce and study a class of generalized Abel transforms and study their properties. This low regularity setting is relevant for geophysical applications.

The Intention-to-Treat Effect of Bridging Treatments in the Setting of Milan Criteria–In Patients Waiting for Liver Transplantation

2019

In patients with hepatocellular carcinoma (HCC) meeting the Milan criteria (MC), the benefit of locoregional therapies (LRTs) in the context of liver transplantation (LT) is still debated. Initial biases in the selection between treated and untreated patients have yielded conflicting reported results. The study aimed to identify, using a competing risk analysis, risk factors for HCC-dependent LT failure, defined as pretransplant tumor-related delisting or posttransplant recurrence. The study was registered at www.clinicaltrials.gov (identification number NCT03723304). In order to offset the initial limitations of the investigated population, an inverse probability of treatment weighting (IP…

Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transpo…

2021

Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's physiological conditions such as pH, residence time, luminal buffers, intestinal motility, and transit and drug properties under fed and fasting conditions (Paixao, P. et al. Mol. Pharm. 2018 and Bermejo, et al. M. Mol. Pharm. 2018). The dissolution of an ionizable drug may benefit from manipulating in vivo variables such as the environmental pH using pH-modifying agents incorporated into the dosage form. A successful example is the use of such agents for dissolution enhancement of BCS class IIb (high-permeability,…

María Magdalena. Continuidad y variación en la cultura audiovisual (1897-2014)

2017

El objetivo principal de esta tesis consiste en analizar la presencia de María Magdalena en las producciones audiovisuales del periodo comprendido entre 1897 y 2014. Dichas producciones proceden de Europa, Estados Unidos, Canadá y México. El marco metodológico general a partir del que se plantea el análisis es la iconología, entendida como Zwichenraum o tierra de confluencias. En concreto, la noción de continuidad y variación, iniciada por Aby Warburg y continuada por Fritz Saxl, es la principal cuestión teórica en la que se basa la aproximación. El estudio se lleva a cabo en perspectiva diacrónica con el objetivo de detectar dichas fases de continuidad y variación del personaje a lo largo …

Applicazione a 5 bacini siciliani di una procedura integrata per lo studio della propagazione delle onde di piena mediante modellazione bidimensional…

2004

La maggiore difficoltà per l’applicazione dei modelli numerici alla simulazione delle onde di piena in alvei naturali consiste nella acquisizione dei dati topografici e in una opportuna discretizzazione spaziale del dominio di calcolo. L’uso di modelli monodimensionali comporta la necessità di assegnare un orientamento prefissato alle sezioni di calcolo, di definire la geometria delle sezioni in base alla cartografia digitale, di tornare alla rappresentazione bidimensionale per la restituzione dei risultati. L’uso di mesh triangolari non strutturate e di metodologie numeriche incondizionatamente stabili consente di realizzare una modellazione bidimensionale che, oltre a produrre risultati m…

Active repair technology applied to delaminated composite structures

2009

The main target of the present paper is represented by the fracture mechanics charac-terization of delaminated composite structures actively repaired through piezoelectric patches. A boundary element code, formulated for anisotropic piezoelectric solids, including, as limiting case, the applicability to linear elastic anisotropic materials has been then imple-mented. The modeling of the delaminated composite structures as well as of the assembled structures, made of the damaged components and the patches, has been achieved through the multidomain technique. Moreover, to take into account for the adhesive layer between the host structures and the piezoelectric patches, a "spring-model" has b…

BE contact analysis of delamination cracks actively repaired trhough piezoelectric active patches

2009

Analysis of piezoelectric active patches performances by boundary element techniques

2008

This paper presents the analysis of active piezoelectric patches for cracked structures by Boundary Element Method. A two dimensional boundary integral formulation based on the multidomain technique is used to model cracks and to assemble the multi-layered piezoelectric patches to the host damaged structures. The fracture mechanics behavior of the repaired structures is analyzed for both perfect and imperfect interface between patches and host beams. The imperfect interface, representing the adhesive between two different layers, is modeled by using a “Spring Model” that involves linear relationships between the interface tractions, in normal and tangential directions, and the respective di…

Correlation of the highest-energy cosmic rays with nearby extragalactic objects.

2007

Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above ~ 6x10^{19} electron volts and the positions of active galactic nuclei (AGN) lying within ~ 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar…