Search results for "PIO"
showing 10 items of 2238 documents
Cannabis e terapia del dolore. Un singolare caso di limitazione del diritto alla cura.
2020
L’articolo descrive l’assetto del mercato della cannabis terapeutica definito dalla legislazione italiana, evidenziandone la dubbia compatibilità con l’ordinario paradigma accolto dalla Corte di Giustizia in materia di diritto della concorrenza. Gli elementi specializzanti alla base di tale devianza possono essere individuati nelle esigenze di tutela della salute pubblica, dell’ordine pubblico e della pubblica sicurezza: questa peculiarità (presupposta dalla normativa italiana e dalla sua matrice internazionale) non consente comunque di giudicare la regolazione della cannabis terapeutica conforme all’interpretazione consolidata degli articoli 49, 52, 56T.f.Ue e alla altrettanto stabile giur…
Knockout of thep-Coumarate Decarboxylase Gene fromLactobacillus plantarumReveals the Existence of Two Other Inducible Enzymatic Activities Involved i…
2000
ABSTRACTLactobacillus plantarumNC8 contains apdcgene coding forp-coumaric acid decarboxylase activity (PDC). A food grade mutant, designated LPD1, in which the chromosomalpdcgene was replaced with the deletedpdcgene copy, was obtained by a two-step homologous recombination process using an unstable replicative vector. The LPD1 mutant strain remained able to weakly metabolizep-coumaric and ferulic acids into vinyl derivatives or into substituted phenyl propionic acids. We have shown thatL. plantarumhas a second acid phenol decarboxylase enzyme, better induced with ferulic acid than withp-coumaric acid, which also displays inducible acid phenol reductase activity that is mostly active when gl…
Competitive Binding of Aroma Compounds by β-Cyclodextrin
2001
Retention of six aroma compounds has been studied after dehydration of ternary mixtures of aroma water and beta-cyclodextrin. A maximal retention of a mole of aroma per mole of beta-cyclodextrin has been observed for five of the aroma compounds, whereas retention of benzyl alcohol can be twice as high. Retention of a mixture of aroma compounds has also been studied. It has been noted that when volatile compounds compete for the same binding sites on beta-cyclodextrin, ethyl hexanoate, 2-methylbutyric acid, and benzyl alcohol are, respectively, better retained than ethyl propionate, hexanoic acid, and hexanol. Preferential retention observed with esters can be simply explained by their diffe…
Carino: homo omnium contaminatissimus o bene agens erga Christianos?
2021
S. Mazzarino leggeva l’ostilità della Historia Augusta verso Carino in parallelo all’attestazione della Passio Cantiorum relativa al cristianesimo dell’imperatore, interpretando i due testi come riflesso della rivalità fra il gruppo paganeggiante dei Nicomachi–Simmachi e quello cristiano dei Probi–Anicii agli inizi del V secolo. Tuttavia, la datazione più tarda della Passio, evidenziata in studi successivi, esclude una concomitanza cronologica fra i due testi. A partire da tali premesse, in questo saggio viene riesaminata nel suo complesso la tradizione storiografica e agiografica su Carino. In particolare, sul versante storiografico il raffronto fra filone greco, con specifico riguardo a E…
La casa di Esichio Libiarca a Cirene, tra architettura ed apparati decorativi. Un esempio di edilizia privata urbana tardoantica.
2009
L'architettura ed i mosaici della casa di Esichio Libiarca rievocano la personalità del committente e rappresentano un documento storico della mutata situazione politica e religiosa nella Cirene del V secolo.
La postura dell’Antonio Cassese «umanitarista» di fronte alla realtà dei conflitti armati: riflessioni a partire da alcuni scritti
2022
Il presente contributo intende ricostruire l’approccio scientifico di Antonio Cassese allo specifico settore del diritto internazionale umanitario, approccio che conferma alcuni tratti più generali del suo pensiero giuridico. La sensibilità del giurista verso la realtà politica, storica e sociale accompagna infatti la produzione scientifica anche in questo settore, contribuendo a tratteggiare la postura di studioso capace di comunicare con (e pungolare) gli Stati. Attraverso tre filoni di indagine (la regolamentazione dei conflitti armati interni; l’(in-)esistenza di meccanismi dedicati di controllo; la dicotomia tra divieti generali e divieti specifici in materia di armi), si dimostra come…
Inulin-Ethylenediamine Coated SPIONs Magnetoplexes: A Promising Tool for Improving siRNA Delivery.
2015
An inulin based polycation (Inu-EDA) has been synthesized by the grafting of ethylenediamine molecules onto inulin backbone. The obtained inulin copolymer has been though to coat SPIONs (IC-SPIONs) and obtain stable magnetoplexes by complexation of IC-SPIONs with a model duplexed siRNA, for improving oligonucleotide transfection efficiency.The physical-chemical characteristics of IC-SPIONs and IC-SPIONs/siRNA magnetoplexes have been investigated by scanning and transmission electron microscopies, dynamic light scattering, FT-IR and qualitative surface elementary analysis. Cell compatibility and internalization in vitro of IC-SPIONs have been evaluated by MTS and fluorescence microscopy resp…
The effects of shock wave stimulation of mesenchymal stem cells on proliferation, migration, and differentiation in an injectable gelatin matrix for …
2020
The treatment of a variety of defects in bony sites could benefit from mitogenic stimulation of osteoprogenitor cells, including endogenous bone marrow-derived mesenchymal stem cells (bMSCs), and from provision of such cells with a matrix permissive of their migration, proliferation, and osteogenic differentiation. That such MSC stimulation could result from treatment with noninvasive (extracorporeal) shock waves (ESWs), and the matrix delivered by injection could enable this therapeutic approach to be employed for applications in which preformed scaffolds and growth factor therapy are difficult to deploy. The objectives of the present study were to investigate focused ESWs for their effect…
MOLECULAR BASIS OF DRUG PHOTOTOXICITY: PHOTOSENSITIZED CELL DAMAGE BY THE MAJOR PHOTOPRODUCT OF TIAPROFENIC ACID
1994
Tiaprofenic acid is a photosensitizing nonsteroidal anti-inflammatory drug, whose major photoproduct (decarboxytiaprofenic acid) is also a potent photosensitizer. Because of the lack of the carboxylate moiety, this photoproduct is more lipophilic and might bind more efficiently to cell membranes, thereby causing phototoxic damage. To verify the feasibility of this hypothesis, we have prepared the 3H-labeled analogs of tiaprofenic acid and its photoproduct and examined the binding, persistence and phototoxicity of the photoproduct using poorly metabolizing (fibroblasts) and actively metabolizing cells (hepatocytes). The photoproduct of tiaprofenic acid accumulates in both cell types as it is…
Hunting for the high-affinity state of G-protein-coupled receptors with agonist tracers: Theoretical and practical considerations for positron emissi…
2019
Abstract The concept of the high‐affinity state postulates that a certain subset of G‐protein‐coupled receptors is primarily responsible for receptor signaling in the living brain. Assessing the abundance of this subset is thus potentially highly relevant for studies concerning the responses of neurotransmission to pharmacological or physiological stimuli and the dysregulation of neurotransmission in neurological or psychiatric disorders. The high‐affinity state is preferentially recognized by agonists in vitro. For this reason, agonist tracers have been developed as tools for the noninvasive imaging of the high‐affinity state with positron emission tomography (PET). This review provides an…