Search results for "PIO"
showing 10 items of 2238 documents
Circostanze aggravanti del reato
2021
La voce enciclopedica si sofferma su alcune recenti tendenze le quali hanno attraversato la “categoria” delle circostanze del reato: in particolare, la moltiplicazione delle circostanze che aggravano il reato, l’uso delle circostanze aggravanti quali strumenti di protezione rafforzata del soggetto passivo, il ricorso alle aggravanti imprecise, l’incremento di deroghe alla disciplina di cui all’art. 69 c.p., la trasformazione di ipotesi circostanziali in fattispecie autonome di reato.
Biosensor-based kinetic and thermodynamic characterization of opioids interaction with human μ-opioid receptor.
2019
Development of opioid analgesics with minimal side effects requires substantial knowledge on structure-kinetic and -thermodynamic relationship of opioid-receptor interactions. Here, combined kinetics and thermodynamics of opioid agonist binding to human μ-opioid receptor (h-μOR) was investigated using real-time label-free surface plasmon resonance (SPR)-based method. The N-terminal end truncated and C-terminal 6His-tagged h-μOR was constructed and expressed in E. coli. Receptor was purified, detergent-solubilized and characterized by circular dichroism. The uniform immobilization of h-μOR on Ni-NTA chips was achieved using hybrid capture-coupling approach followed by reconstitution in lipid…
Ridisegnare il confine fra "noi" e "loro": interrogativi sulla revoca della cittadinaza
2019
Esiste un limite costituzionale alla privazione della cittadinanza? Il decreto legge n. 113/2018 ha recentemente introdotto un nuovo articolo 10-bis nella legge n. 91/1992 che disciplina la revoca della cittadinanza. Si tratta di una “sanzione” che può essere inflitta dal Presidente della Repubblica su proposta del Ministro dell’interno entro tre anni dalla condanna definitiva per gravi fatti di reato ed è applicabile soltanto ad alcune categorie di cittadini (non si può revocare la cittadinanza ai cittadini iure sanguinis, per beneficio di legge o per adozione). La revoca della cittadinanza è una assoluta novità nella legislazione italiana a far data dalle leggi fasciste del 1926 e sembra …
The urban revitalization of the coastal tourist destinations: An alternative for the Valencian Mediterranean tourist municipalities
2021
espanolLos municipios del litoral mediterraneo valenciano aumentaron sensiblemente su superficie construida por la irrupcion de la actividad turistica a mediados del siglo XX. A pesar de las ventajas iniciales, los problemas surgidos sobre el espacio urbano, por la naturaleza del modelo de desarrollo turistico utilizado, los dirigen hacia una perdida progresiva de su atractivo turistico. Ante esta circunstancia, se hace necesario intervenir sobre el espacio urbano, no solo para renovar el destino turistico sino tambien para corregir los problemas urbanos generados durante las ultimas decadas en unos municipios que supeditaron sus decisiones exclusivamente a las necesidades turisticas. Una o…
“AD HOC” MODIFIED CLAYS FOR BIOTECHNOLOGICAL APPLICATIONS
Nowadays, the scientific community has to face with cogent problems strictly linked to the improvement of quality of live. Among the different tasks to achieve the prefixed objective the focus has been put on the drug administration, i.e., attention has been paid to propose an appropriate solution to improve the performance of a drug delivery system and to eliminate both the side effect and drawbacks. With the aim to achieve the design, synthesis, and characterization of versatile systems, with peculiar characteristics, based on clays and clays modified with a biocompatible surfactant, able to adsorb and release organic substances of pharmaceutical interest the present PhD thesis has been u…
Salsolinol and ethanol-derived excitation of dopamine mesolimbic neurons: new insights
2013
Evidence supporting the essential role of brain-derived ethanol metabolites in the excitation of dopamine (DA) midbrain neurons has multiplied in the last 10–15 years. The pioneer and influential behavioral studies by CM Aragon and colleagues (see Correa et al., 2012 for a complete review) and more recent data (Sanchez-Catalan et al., 2009; Marti-Prats et al., 2010, 2013) have repeatedly demonstrated the crucial role displayed by acetaldehyde (ACD) in the locomotor and other behavioral responses elicited by ethanol. Although these experiments mainly used an indirect measure (exploratory locomotion) as an index of the excitation of DA neurons in the ventral tegmental area (VTA), results stro…
Fundacion del Colegio de San Pio, hecha por el ... Arçobispo de Valencia : para la qual obtuvo licencia de su magestad, que Dios guarde, con el assen…
El Col·legi va ser fundat per Juan Tomás de Rocabertí, Arquebisbe de València i el Rei al que fa referència el tít. es Carles II Sign.: [ ]2
Nowe dane o rozmieszczeniu 50 gatunków ryjkowców (Coleoptera: Curculionoidea) w Polsce
2016
Fifty weevil species have been recorded from new localities in Poland. They belong to four families: Anthribidae (1), Apionidae (6), Nanophyidae (2) and Curculionidae (41). The new records, 124 in all, are from 64 UTM squares (10×10 km) in 17 of 24 regions of Poland, according to the division adopted from the Catalogus Faunae Poloniae issued in 1971-2000. Nearly half of them (57) are first records for a region. The largest numbers of the new records are from the Małopolska Upland (13), the Pomeranian Lakeland (8), Upper Silesia (7) and the Wielkopolsko-Kujawska Lowland (5). Kyklioacalles navieresi (Boh.) has been recorded from Poland for the first time, whereas K. roboris (Curtis) has been …
El problema de la aplicación tardía del principio de precaución en las aspersiones aéreas con Glifosato contra cultivos de uso ilícito en Colombia: L…
Flscalidad y sociedad en la Baja Edad Media
1996
furio@uv.es