Search results for "PIP"

Pharmacology and safety of tofacitinib in ulcerative colitis.

2020

The use of Janus kinase (JAK) inhibitors is a new approach in the therapy of inflammatory diseases with immune base. Tofacitinib is one of these inhibitors targeting JAK1 and JAK3, and its efficacy has been demonstrated in the treatment of moderate to severe ulcerative colitis (UC). It is a small synthetic molecule administered orally, with a fast bioavailability and elimination rate, predictable pharmacokinetics and lack of immunogenicity, which are convenient characteristics for both efficacy and safety. This article reviews the pharmacological characteristics of tofacitinib and its safety profile.

Stereoselective solid-phase synthesis of chiral piperidine derivatives by using an immobilized galactose auxiliary.

2003

Molecular Dynamics Computer Simulation of Cooling Rate Effects in a Lennard-Jones Glass

1995

We present the results of a molecular dynamics computer simulation of a binary Lennard-Jones mixture. We simulate a quench of the system from a liquid state at high temperatures to a glass state at zero temperature by coupling the system to a heat bath that has a temperature that decreases linearly (with slope -γ) with time. We investigate how the residual density of the system varies as a function of the cooling rate γ and rationalize our results by means of the dependence of the coordination number of the particles on the cooling rate.

Moritz Brosig (1815-1887) - działalność organoznawcza na Śląsku Opolskim na podstawie zbiorów Archiwum Państwowego w Opolu

2020

Moritz Brosig (1815–1887) był śląskim muzykiem, organistą i kompozy-torem. Jego twórcza działalność koncentrowała się na szeroko pojętej muzyce liturgicznej. Archiwum Państwowe w Opolu przechowuje 35 opinii organoznawczych sporządzonych przez niego w latach 1871–1884, które dotyczą instrumentów na Śląsku Opolskim. Jest to niezwykle interesujący i bogaty zestaw dokumentów, pełen ciągle nieodkrytej wiedzy o śląskim budownictwie organowym XVIII–XX w. Artykuł prezentuje zawartość opinii eksperckich Moritza Brosiga. Autor skupia się na kwestiach brzmieniowych, ale wymienia także wiele nazw ówczesnych warsztatów organmistrzowskich.

Real-time 6-DOF Vessel-to-Vessel Motion Compensation using laser tracker

2017

The industry state-of-the-art offshore motion compensation is today carried out by offshore cranes equipped with Active Heave Compensation (AHC) systems, meaning that a hanging load is positioned at a certain height above the seafloor, even though the floating vessel carrying both the crane and the load is moving due to wave disturbances. Lately, there has been an increased interest among the industry also to compensate for the movement of a secondary vessel, which indicates that a more detailed investigation of the Vessel-to-Vessel Motion Compensation (VVMC) problem is required. The primary motivation for such compensation technique is influenced by the demand for load transfer between shi…

A Red Eye Colour Mutation in Culex pipiens after X-irradiation

1963

FOUR 1–2-day-old males of Culex pipiens were irradiated with a dose of 4,000 r. The mutant ‘red eye’ (r) was isolated from F3 cultures of two of the irradiated males (♂ II and ♂ IV). From male II, there were three red-eyed females which arose out of a single F2 brother–sister mating; from male IV, 80 red-eyed females and one red-eyed male from 14 F2 brother–sister matings. According to the experimental procedure, this means that at least one sperm from male II and at least fourteen sperms from male IV carried the mutation r. Thus, the same mutation was recovered in parallel from two irradiated males. The clustered appearance of the mutation in male IV was presumably caused by the occurrence…

Eradication of Culex pipiens fatigans through Cytoplasmic Incompatibility

1967

Culex pipiens fatigans is the chief vector of filariasis in south-east Asia. Urbanization has often caused the numbers of this mosquito—and with it the danger of filariasis infection—to increase alarmingly1. The natural vigour, tolerance and fast development of resistance to insecticides of this mosquito necessitate the development of other control methods, and cytoplasmic incompatibility2 seems to be an ideal means.

ECONOMIC EVALUATION OF AQUACULTURE INVESTMENTS UNDER CONDITIONS OF RISK AND UNCERTAINTY IN THE MEDITERRANEAN SEA

2014

This study aims to analyze, from a technical and ec onomic point of view, the choice between alternative investments in aquaculture under condit ions of risk and uncertainty. In particular, a comparative analysis has been conducted between an inshore and an offshore farm producing European sea bass in the Mediterranean Sea. The app lied model refers to the theory of subjective probability, assigning a different probability to e xpected incomes during the investment period. Resul ts show an economic convenience of inshore with respect to offshore farming.

Effect of an Insect Growth Regulator (Halofenozide) on the Cuticular Hydrocarbons ofCulex pipiensLarvae

2013

The cuticular hydrocarbons of the fourth-instar larvae of Culex pipiens aged one and six days were analysed by gas chromatography and gas chromatography-mass spectrometry. The effect of an insect growth regulator (halofenozide = RH-0345) on the cuticular hydrocarbons was evaluated using newly moulted fourth-instar larvae of C. pipiens, at the lethal concentrations (LC50 = 12.58 and LC90 = 28.58 µ/l). A previous study revealed that RH-0345 is toxic to larvae of C. pipiens by induction of precocious larval moulting. Several cuticular hydrocarbons (CHCs) were identified and many of the other compounds remained unknown. Our data show that the CHC classes consisted of n-alkanes (C23-C29) and dif…

CCDC 1420809: Experimental Crystal Structure Determination

2018

Related Article: Inese Sarceviča, IlzeGrante, Sergey Belyakov, Toms Rekis, Kārlis Bērziņš, Andris Actiņš, Liāna Orola|2016|J.Pharm.Sci.|105|1489|doi:10.1016/j.xphs.2016.01.024